Effect of streptozotocin diabetes on some urea cycle enzymes

Jordá, A.; Gómez, Marta I.; Cabo, J; Grisolı́a, Santiago

doi:10.1016/0006-291x(82)92054-x

Cited by 31 publications

(11 citation statements)

References 25 publications

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“…11) Treatment with CiREE was sufficient to normalize these enzyme activity levels. Increased activity levels of AST and ALT in the diabetic liver were also reported by Jorda et al 26) Increased protein catabolism during gluconeogenesis and urea formation, which has been reported in the diabetic state, might be responsible for the elevation of these tissue transaminases. The elevated activity of ALT has been shown to be caused by hepatocellular damage and is usually accompanied with a rise in AST.…”

Section: Parameterssupporting

confidence: 74%

The Efficacy of <i>Costus igneus</i> Rhizome on Carbohydrate Metabolic, Hepatoproductive and Antioxidative Enzymes in Streptozotocin-induced Diabetic Rats

Kalailingam

Matheswaran

Samuel

et al. 2011

JOURNAL OF HEALTH SCIENCE

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In this study, effect of an ethanolic extract from rhizome of Costus igneus were investigated on activity of following enzyme in liver, kidney, pancreas of streptozotocin (STZ) induced diabetic rats: carbohydrate metabolic enzymes such as glucokinase glucose-6-phosphatase, and fructose-1,6-bisphosphatase in the liver; hepatoproductive enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in plasma and liver; and antioxidative enzymes such as superoxide dimutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione content (GSH), total sulfhydryl groups (TSH), lipid peroxides (LPO) in liver, kidney and pancreas. An ethanol extract from Costus igneus rhizome was administrated orally at a single dose of 100 or 200 mg/kg per day to diabetes induced rats for 30 days. This study demonstrated that glucose-6-phosphatase fructose-1,6-bisphosphatase, AST, ALT, ALP and LPO levels were significantly increased (p < 0.05), whereas glycolytic enzyme glucokinase, SOD, CAT, GPx, GSH and TSH levels were significantly decreased (p < 0.05) in STZ induced diabetic rats. Oral administration of Costus igneus rhizome ethanol extract [CiREE, 100 or 200 mg/kg per body weight (bw)] and glibenclamide to diabetic rats for 30 days significantly (p < 0.05) reversed levels of these enzymes to normal. Bioactive compound quercetin and diosgenin were isolated from Costus igneus rhizome by high performance thin layer chromatography (HPTLC). These results suggest that, components of CiREE quercetin and diosgenin exhibit antioxidant activity, which was sufficient to reverse oxidative stress in the liver, pancreas and kidney of diabetic rats as well as to stimulate glycolytic enzymes and control gluconeogenesis in diabetic animals.

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Section: Parameterssupporting

confidence: 74%

The Efficacy of <i>Costus igneus</i> Rhizome on Carbohydrate Metabolic, Hepatoproductive and Antioxidative Enzymes in Streptozotocin-induced Diabetic Rats

Kalailingam

Matheswaran

Samuel

et al. 2011

JOURNAL OF HEALTH SCIENCE

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show abstract

“…Increased catabolism of both liver and kidney proteins may account for the diabetes associated elevated BUN [55]. While earlier studies have demonstrated the propensity of organophosphates to induce nephrotoxicity in humans occupationally exposed to these compounds [56]. From our data, the degree of nephrotoxicity was greater in diabetic rats than in DDVP exposed rats, as evident from higher level of BUN and creatinine.…”

Section: Discussionsupporting

confidence: 45%

Dichlorvos Exposure Aggravates Complications Associated with Diabetes in Wistar Rats

2016

International Journal of Research Studies in Biosciences

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“…Activity of ornithine transcarbamoylase is increased significantly (p <0.001) in diabetic rats [5]. Arginosuccinase increases significantly (p<0.001) in diabetic rat liver [3].…”

Section: Discussionmentioning

confidence: 87%

Insulin-Like Effect of Sodium Orthovanadate on Urea-Cycle Enzymes in Streptozotocin Diabetic Rats.

Maneemegalai

Sekar

Govindasamy

1994

J. Clin. Biochem. Nutr.

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Effect of streptozotocin diabetes on some urea cycle enzymes

Cited by 31 publications

References 25 publications

The Efficacy of <i>Costus igneus</i> Rhizome on Carbohydrate Metabolic, Hepatoproductive and Antioxidative Enzymes in Streptozotocin-induced Diabetic Rats

The Efficacy of <i>Costus igneus</i> Rhizome on Carbohydrate Metabolic, Hepatoproductive and Antioxidative Enzymes in Streptozotocin-induced Diabetic Rats

Dichlorvos Exposure Aggravates Complications Associated with Diabetes in Wistar Rats

Insulin-Like Effect of Sodium Orthovanadate on Urea-Cycle Enzymes in Streptozotocin Diabetic Rats.

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