Effect of stress and stress hormones on the hormone (insulin) binding of Tetrahymena

Csaba, G.; Pállinger, Éva

doi:10.1002/cbf.1592

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…This is similar to reports indicating that thermal therapy (saunas and hot baths) improves insulin sensitivity in humans (146). Insulin's role in thermal stress adaptation appears to be an ancient mechanism preserved during evolution as even heat-stressed simple eukaryotes increase both insulin synthesis and insulin binding (147). Regardless of why, heat stress is one of the very few nondiabetic models of which we are aware in which nutrient intake is markedly reduced, but basal and stimulated insulin levels are increased.…”

Section: Systemic Heat Stress Responsesupporting

confidence: 87%

Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress

Rhoads

Baumgard

Suagee

et al. 2013

Advances in Nutrition

192

135

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Energy metabolism is a highly coordinated process, and preferred fuel(s) differ among tissues. The hierarchy of substrate use can be affected by physiological status and environmental factors including high ambient temperature. Unabated heat eventually overwhelms homeothermic mechanisms resulting in heat stress, which compromises animal health, farm animal production, and human performance. Various aspects of heat stress physiology have been extensively studied, yet a clear understanding of the metabolic changes occurring at the cellular, tissue, and whole-body levels in response to an environmental heat load remains ill-defined. For reasons not yet clarified, circulating nonesterified fatty acid levels are reduced during heat stress, even in the presence of elevated stress hormones (epinephrine, glucagon, and cortisol), and heat-stressed animals often have a blunted lipolytic response to catabolic signals. Either directly because of or in coordination with this, animals experiencing environmental hyperthermia exhibit a shift toward carbohydrate use. These metabolic alterations occur coincident with increased circulating basal and stimulated plasma insulin concentrations. Limited data indicate that proper insulin action is necessary to effectively mount a response to heat stress and minimize heat-induced damage. Consistent with this idea, nutritional interventions targeting increased insulin action may improve tolerance and productivity during heat stress. Further research is warranted to uncover the effects of heat on parameters associated with energy metabolism so that more appropriate and effective treatment methodologies can be designed.

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Section: Systemic Heat Stress Responsesupporting

confidence: 87%

Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress

Rhoads

Baumgard

Suagee

et al. 2013

Advances in Nutrition

192

135

View full text Add to dashboard Cite

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“…The POMC-hormone, adrenocorticotropine (ACTH) is also produced by Tetrahymena as well as endorphin [33][34][35][36]. This latter was found mainly in the cortical structures, oral field, cilia and nuclear envelope [37].…”

Section: Peptide Hormonesmentioning

confidence: 99%

“…Long-lasting starvation increases its hormone (endorphin, ACTH, insulin, serotonin, histamine and triiodothyronine) levels [10]. Insulin binding is also touched by stress [36,69].…”

Section: General Hormonal Effects (Stress)mentioning

confidence: 99%

The hormonal system of the unicellular Tetrahymena: A review with evolutionary aspects

Csaba

2012

Acta Microbiologica Et Immunologica Hungarica

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The unicellular ciliate, Tetrahymena has receptors for hormones of the higher ranked animals, these hormones (e.g. insulin, triiodothyronine, ACTH, histamine, etc.) are also produced by it and it has signal pathways and second messengers for signal transmission. These components are chemically and functionally very similar to that of mammalian ones. The exogenously given hormones regulate different functions, as movement, phagocytosis, chemotaxis, cell growth, secretion, excretion and the cells' own hormone production. The receptors are extremely sensitive, certain hormones are sensed (and response is provoked) at 10-21 M concentration, which makes likely that the function could work by the effect of hormones produced by the Tetrahymena itself. The signal reception is selective, it can differentiate between closely related hormones. The review is listing the hormones produced by the Tetrahymena, the receptors which can receive signals and the signal pathways and second messengers as well, as the known effects of mammalian hormones to the life functions of Tetrahymena. The possible and justified role of hormonal system in the Tetrahymena as a single cell and inside the Tetrahymena population, as a community is discussed. The unicellular hormonal system and mammalian endocrine system are compared and evolutionary conclusions are drawn.

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“…Not only the hormone-production, but hormone binding was also stimulated by stress. Long (24 h) starvation elevated the insulin binding of Tetrahymena and this was not changed immediately after short re-feeding [14,16]. Other stressors, as 5, 10, or 20 mg/ml NaCl or 0.01%, 0.1% or 0.05% formaldehyde treatment as well as 37 °C thermal stress elevated the insulin binding by Tetrahymena.…”

Section: Effect Of Stress To the Hormonal System Of Tetrahymenamentioning

confidence: 92%

Hormonal actions in the Protozoan stress: A review

Csaba

2015

Acta Microbiologica et Immunologica Hungarica

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In the higher ranked animals the alteration of the environment can provoke a uniform reaction named general adaptation system (GAS), which is a manifestation of stress, caused by different stressors. During GAS certain organs show typical reactions and two members of the hormonal system are activated: epinephine and glucocorticoids. As the unicellular ciliate Tetrahymena also synthesize most of the mammalian-like hormones (except steroids), it can respond to stress by a hormonal reaction. The main differences, related to the mammalian GAS hormonal reaction are, that 1) in Tetrahymena the level of all of the hormones studied significantly elevates under the effect of heat, osmotic or chemical stress and 2) the single stress effect is durable. It is manifested at least to the 100th generations, which means that it is inherited epigenetically. Not only hormone synthesis but the receptorial hormone binding is also elevated, which means that the whole hormonal system is activated. The stress reaction (GAS) phylogenetically can be deduced to a unicellular (Protozoan) level however, prokaryotes - which are also stress-reactive - are using another mechanisms.

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Effect of stress and stress hormones on the hormone (insulin) binding of Tetrahymena

Cited by 6 publications

References 26 publications

Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress

Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress

The hormonal system of the unicellular Tetrahymena: A review with evolutionary aspects

Hormonal actions in the Protozoan stress: A review

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