Effect of stress on cochlear glucocorticoid protein. II. Restraint

Curtis, Lisa M.; Rarey, Kyle E.

doi:10.1016/0378-5955(95)00207-3

Cited by 25 publications

(16 citation statements)

References 13 publications

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“…In spite of demonstrable effects of restraint stress on the inner ear, the underlying mechanisms are not well understood [6,7]. A study by Curtis and Rarey [4] showed tissue-specific up or down-regulation of glucocorticoid receptors (GRs) in different cochlea tissues after restraint stress. Altered corticosterone levels, however, were not found as blood was collected well beyond the time expected for corticosterone changes [4].…”

Section: Introductionmentioning

confidence: 98%

“…The ultimate impact of stress on the organism depends on the type and intensity of the stressor, as well as, the sensitivity of the particular tissue under stress. An experimental model for stress is restraint stress, which has been well documented to have effects in the central nervous system [1], the immune system [2], the digestive system [3], and the auditory system [4,5]. In spite of demonstrable effects of restraint stress on the inner ear, the underlying mechanisms are not well understood [6,7].…”

Section: Introductionmentioning

confidence: 98%

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Restraint stress modulates glucocorticoid receptors and nuclear factor kappa B in the cochlea

Tahera¹,

Meltser²,

Johansson³

et al. 2006

NeuroReport

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The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma corticosterone levels and glucocorticoid receptor nuclear translocation increased. By 24 h after restraint stress, the protein expression of glucocorticoid receptors was decreased in spiral ganglion neurons. Pre-treatment with RU486 and metyrapone prevented nuclear translocation of glucocorticoid receptors and nuclear factor kappaB. Moreover, the synthesis of nuclear factor kappaB protein (p65) and inhibitory factor kappaBalpha decreased when RU486 and metyrapone treatment was given before restraint stress. These findings suggest that restraint stress modulates glucocorticoid receptor and nuclear factor kappaB activity in the spiral ganglion neurons, resulting in an altered response to stress.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Restraint stress modulates glucocorticoid receptors and nuclear factor kappa B in the cochlea

Tahera¹,

Meltser²,

Johansson³

et al. 2006

NeuroReport

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“…They showed that glucocorticosteroid receptors are present in inner ear tissues in varying levels and that they are responsive to stress (6,17). It seems that glucocorticosteroids could directly affect glucocorticosteroid receptor protein within the inner ear and not only suppress the systemic release of corticosterone (18). Furthermore, adrenal corticoids appear to cause changes in auditory thresholds (7).…”

Section: Discussionmentioning

confidence: 97%

Analysis of Cortisol and Other Stress-Related Hormones in Patients with M??ni??re??s Disease

Cruijsen¹,

Dullaart²,

Wit³

et al. 2005

Otology & Neurotology

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“…After immobilization stress, glucocorticoid receptor levels of rats increased in spiral ligament tissues and decreased in the organ of Corti, while the levels in stria vascularis tissues remained unchanged [78].…”

Section: Expression Of Glucocorticoid Receptorsmentioning

confidence: 99%

How Useful Is Corticosteroid Treatment in Cochlear Disorders?

Lamm¹,

Arnold²

1999

Otorhinolaryngol Nova

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The scientific basis for the administration of corticosteroids classified as glucocorticoids in certain cochlear disorders, such as immune-mediated progressive and idiopathic acute sensorineural hearing loss (SNHL), Ménière’s disease and noise-induced hearing loss (NIHL), was discussed. The current knowledge on the physiological functions of endogenous glucocorticoids and the pharmacological effects of their synthetic analogs was summarized. Emphasis was placed on experimental studies on corticosteroids in the cochleovestibular system and on the therapeutic effects of glucocorticoids on SNHL, Ménière’s disease, NIHL and chronic tinnitus obtained from clinical trials. Glucocorticoids exert numerous profound effects on almost every organ system, including mechanisms involved in anti-inflammatory action and immunosuppression. However, inflammatory tissue alterations are not only elicited by bacterial, viral or other immunopathological processes but also by physically and chemically induced cellular damage, tissue ischemia and hypoxia. Regardless of whether one or more of these insults underlie SNHL, Ménière’s disease and NIHL, glucocorticoids effectively counteract subsequent inflammatory tissue damage in the auditory and vestibular system. This was confirmed in experimental studies on immune-mediated progressive SNHL, and thrombosis-induced and noise-induced cochlear ischemia, hypoxia and hearing loss. Glucocorticoid treatment results of immune-mediated progressive and acute idiopathic SNHL are promising, although placebo-controlled trials on the effect in acute idiopathic SNHL have revealed conflicting data (probably due to the small number of patients). Clinical studies on the effect of systemic glucocorticoid monotherapy on Ménière’s disease and NIHL have not yet been performed. After intratympanic application, relief of vertigo, tinnitus and preservation of hearing in Ménière’s disease was observed in previous studies; however, recently none of these effects have been confirmed in a placebo-controlled trial. Similarly, in contrast to previous reports, chronic tinnitus of various origins did not improve after repetitive glucocorticoid application onto the round window membrane using a micropump connected to an implanted microcatheter.

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Effect of stress on cochlear glucocorticoid protein. II. Restraint

Cited by 25 publications

References 13 publications

Restraint stress modulates glucocorticoid receptors and nuclear factor kappa B in the cochlea

Restraint stress modulates glucocorticoid receptors and nuclear factor kappa B in the cochlea

Analysis of Cortisol and Other Stress-Related Hormones in Patients with M??ni??re??s Disease

How Useful Is Corticosteroid Treatment in Cochlear Disorders?

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