Effect of Stress upon the Healing of Wounds in Rats.

Effect of Thermal Burns on Wound Healing*

“…Histologic examination revealed identical findings (Figs. 4 and 5) in both groups, findings which were indistinguishable from those seen in unburned animals receiving 2 mg. of ascorbic acid daily (Fig. 1).…”

Wound Healing Associated with Severe Surgical Illness

“…Diegelmann et al showed in a small study of five patients with severe injuries [median Injury Severity Score (ISS) 25] that hydroxyproline accumulation at 14 days was only 40% that of normal volunteers (p Ͻ 0.05) [44]. This result is supported by a number of animal studies, particularly those of thermal injury [53][54][55]. The link between trauma and the impairment in wound healing may be lymphocyte function, and this area has been comprehensively reviewed [56].…”

The Effect of Thyroxine on Wound Healing in Normal and Ascorbic Acid Deficient Guinea Pigs

“…( 8 0 ) found an increased weight of foreign body granulomas during treatment with thyroxine. Chassin et al ( 5 ) , however, measuring tensile strength of laparotomy wounds, found this to he reduced by thyroxine. A s a t the same timc the weights of the adrenal glands were increased, they advanced the hypothesis that the subdued healing was caused by a stress reaction.…”