Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.

Chen, Ping; Geurts, Dirk E. M.; Määttä, Jessica I; Bosch, Ruben van den; Hofmans, Lieke; Papadopetraki, Danae; Ouden, H.E.M. den; Cools, Roshan

doi:10.1037/bne0000547

Cited by 6 publications

(2 citation statements)

References 71 publications

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“…In past studies using the same task, we and others have observed that sometimes participants respond deterministically to a particular Pavlovian / Action Context combination regardless of the instrumental stimulus presented (e.g., Chen et al, 2023). For example, a participant would always make a Go response when a certain appetitive Pavlovian cue was present in an approach context.…”

Section: Deterministic Pit Respondingmentioning

confidence: 87%

Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

Geurts,

Ouden,

Swart

et al. 2024

Preprint

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Value-based decision-making is regulated by a delicate interplay of instrumental and Pavlovian controllers. Here we assessed the role of catecholamines in this interplay. We investigated the effects of the catecholamine reuptake inhibitor methylphenidate (MPH) in 100 healthy subjects using a combined appetitive and aversive Pavlovian to instrumental transfer (PIT) paradigm including approach and withdrawal actions. By administering the drug after learning, our design allowed us to establish that MPH can also bias action outside a learning context by directly modulating the expression of motivational bias on instrumental action rather than by only modulating instrumental learning bias. In line with previous results, the effect of MPH on bias varied across individuals as a function of their working memory span capacity. By assessing both approach and withdrawal actions, we revealed that MPH enhanced not only the invigorating effect of appetitive Pavlovian cues on active approach, but also the inhibitory effect of appetitive cues on active withdrawal, the invigorating effect of aversive cues on active withdrawal, and the inhibitory effect of aversive cues on active approach. Thus, in participants with high working memory capacity, MPH boosted both approach and withdrawal PIT. Taken together, this pattern of effects is most consistent with the hypothesis that MPH modulates the cognitive control of Pavlovian biasing in a baseline-state-dependent manner, in line with the well-established inverted-U shaped relationship between catecholamine receptor stimulation in prefrontal cortex, and cognitive control.

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Section: Deterministic Pit Respondingmentioning

confidence: 87%

Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

Geurts,

Ouden,

Swart

et al. 2024

Preprint

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“…Likewise, previous work has linked Pavlovian biases with neuromodulators such as dopamine and serotonin (Boureau & Dayan, 2011;Chen, 2023;Guitart-Masip, Economides et al, 2014;Rutledge et al, 2016), as well as activity in the striatum more generally (Cavanagh et al, 2013). Future work could employ pharmacological and/or neuroimaging methods in order to probe the underlying mechanism of this effect.…”

Section: Transfer Effectsmentioning

confidence: 99%

Cognitive training reduces the strength of Pavlovian biases

Fleming,

Feng,

Rutledge

et al. 2023

Preprint

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Pavlovian biases are fixed patterns of responses that include approaching stimuli associated with reward and avoiding those associated with punishment. These prepotent behavioural responses can sometimes conflict with those produced by other behavioural action selection systems, giving rise to suboptimal behaviour. This is particularly important in the context of affective disorders like anxiety and depression, in which Pavlovian biases are enhanced (Mkrtchian et al., 2017; Nord et al., 2018), and are thought to contribute to the induction and maintenance of symptoms (Dayan & Huys, 2008). In this study we investigated whether participants could be trained to exert more control over these biases. This would present a potential new opportunity for treating anxiety and depression. In addition, it would be the first direct, behavioural demonstration that Pavlovian biases are modifiable. We conducted a double-blind, sham-controlled study (N=800) and found that the active training intervention was indeed effective: after selectively practicing the conflict trials of the Orthogonal Go/No-Go task (Guitart-Masip et al., 2011), which require high control, participants were more accurate and showed less influence of Pavlovian biases (especially avoidance bias) when tested on the full task. We discuss what this means for understanding Pavlovian biases, and suggest that future studies should now be aimed at facilitating transfer of these effects to other aspects of anxiety and depression symptoms.

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How dopamine shapes trust beliefs

Schuster,

Lamm

2025

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study.

Cited by 6 publications

References 71 publications

Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity

Cognitive training reduces the strength of Pavlovian biases

How dopamine shapes trust beliefs

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