Effect of Structured Physical Activity on Inflammation and Immune Activation Profile of Antiretroviral Therapy-Experienced Children Living With HIV

Gopalan, B.; Dias, Mary; Arumugam, Karthika; D'Souza, Reena R; Perumpil, Mathew; Kulkarni, Prasanna; Ranga, Udaykumar; Shet, Anita

doi:10.1123/pes.2019-0126

Cited by 6 publications

(14 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 1 illustrates the PRISMA 2020 flow diagram for the selection process of the studies: a total of 1,473 articles were included from the three databases, and after removing the duplicates and non-eligible studies, 15 articles remained eligible for this review (6 cross-sectional articles, 5 studies reported the acute effects of physical activity, and 5 articles showed the chronic effects of physical activity). The sample size ranged from 12 to 369 participants (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). The age of participants ranged from 9 to 18 years old (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Resultsmentioning

confidence: 99%

“…The sample size ranged from 12 to 369 participants (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). The age of participants ranged from 9 to 18 years old (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Thirteen studies used blood samples (27,(29)(30)(31)(32)(34)(35)(36)(37)(38)(39)(40) while 2 saliva (33) and buccal swabs (28) respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The age of participants ranged from 9 to 18 years old (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Thirteen studies used blood samples (27,(29)(30)(31)(32)(34)(35)(36)(37)(38)(39)(40) while 2 saliva (33) and buccal swabs (28) respectively. Regarding disease, four studies included children with obesity (27,34,37,40) and 1 study children with HIV infection (29).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

BackgroundThe links of sedentary behavior and physical activity with health outcomes in children and adolescents is well known. However, the molecular mechanisms involved are poorly understood. We aimed to synthesize the current knowledge of the association of sedentary behavior and physical activity (acute and chronic effects) with gene expression and epigenetic modifications in children and adolescents.MethodsPubMed, Web of Science, and Scopus databases were systematically searched until April 2022. A total of 15 articles were eligible for this review. The risk of bias assessment was performed using the Joanna Briggs Institute Critical Appraisal Tool for Systematic Reviews and/or a modified version of the Downs and Black checklist.ResultsThirteen studies used candidate gene approach, while only 2 studies performed high-throughput analyses. The candidate genes significantly linked to sedentary behavior or physical activity were: FOXP3, HSD11B2, IL-10, TNF-α, ADRB2, VEGF, HSP70, SOX, and GPX. Non-coding Ribonucleic acids (RNAs) regulated by sedentary behavior or physical activity were: miRNA-222, miRNA-146a, miRNA-16, miRNA-126, miR-320a, and long non-coding RNA MALAT1. These molecules are involved in inflammation, immune function, angiogenic process, and cardiovascular disease. Transcriptomics analyses detected thousands of genes that were altered following an acute bout of physical activity and are linked to gene pathways related to immune function, apoptosis, and metabolic diseases.ConclusionThe evidence found to date is rather limited. Multidisciplinary studies are essential to characterize the molecular mechanisms in response to sedentary behavior and physical activity in the pediatric population. Larger cohorts and randomized controlled trials, in combination with multi-omics analyses, may provide the necessary data to bring the field forward.Systematic Review Registration[www.ClinicalTrials.gov], identifier [CRD42021235431].

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, although “no evidence of effect” could be sustained, a systematic review including 23 clinical trials and 1073 participants [ 14 ] could not find an association between beneficial effects and biomarker improvements after ≥4 weeks of aerobic or/and resistance exercise. A longer-term study carried out retrospectively in children with HIV who practiced exercise regularly for 2 years showed reduced levels of immune activation markers such as sCD14, TNF-α, interferon-gamma (IFN-γ), and IL-10, and lower expression of CD38 on CD4 + T cells [ 26 ]. This latter result is in concordance with the reduction on activation markers expressed in CD4 + and CD8 + T cells and NK cells in patients with higher physical activity from our series.…”

Section: Discussionmentioning

confidence: 99%

Moderate to Intense Physical Activity Is Associated With Improved Clinical, CD4/CD8 Ratio, and Immune Activation Status in HIV-Infected Patients on ART

Bernal

Martínez

Campillo

et al. 2021

Open Forum Infectious Diseases

View full text Add to dashboard Cite

Background Physical activity has anti-inflammatory effects and reduces morbidity and mortality in general population, but its role in the clinical, CD4/CD8 ratio and immune activation status in HIV-infected patients has been poorly studied. Methods A cross-sectional study was carried out in a cohort of 155 HIV-infected patients on stable ART to compare clinical, biochemical, CD4/CD8 ratio and immune-activation status according to their physical activity in the last two years (sedentary/low vs. moderate/intense) assessed by the iPAQ. A binary logistic regression and mixed ANOVA were performed to evaluate the impact of levels of physical activity on CD4/CD8 ratio. Results In our series 77 (49.7%) out of 155 patients were sedentary and 78 (50.3%) practiced moderate/intense physical activity. Moderate/intense physical activity was associated with lower CDC HIV-stage (p=0.046), better metabolic control (lower BMI, p=0.024; glucose, p=0.024; and triglyceride, p=0.002), higher CD3 +CD4 + T lymphocytes (p=0.016), lower CD8 + T lymphocytes (p=0.018), higher CD4/CD8 ratio (p=0.001), lower CD4 +CD8 + (p=0.026), CD4 +CD86 + (p=0.045), CD4 +HLA-DR + (p=0.011), CD8 +HLA-DR + (p=0.048) T lymphocytes and CD16 +HLA-DR + NK cells (p=0.026). Sedentary lifestyle (OR=2.12, p=0.042), CD4 nadir (OR=1.005, p<0.001) and CD8 +CD38 + T cells (OR=1.27, p=0.006) were independently associated with low CD4/CD8 ratio (<0.8). Earlier and more intense CD4/CD8 ratio recovery was observed in patients with higher physical activity in the two-year follow-up with a significant interaction between these variables: F(2, 124) = 3.31, p=0.049, partial η2=0.042). Conclusions Moderate to high physical activity is associated with beneficial health effects, improving metabolic profile and reducing chronic inflammation in patients living with HIV. Although more studies and clinical trials are needed to confirm these findings, healthy lifestyle, including at least moderate physical activity, should be recommended to HIV patients on stable ART.

show abstract

“…It is therefore important to continue to monitor the growth and endurance levels of all children as they go through adolescence as the impairments experienced by children may change. High levels of MVPA and aerobic fitness may also have additional benefits in CLHIV, such as the prevention of cardiovascular risk factors commonly experienced (De Lima et al 2019 ) or improving inflammatory profiles (Gopalan et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of submaximal endurance in young children living with HIV

Potterton

Strehlau

Shiau

et al. 2022

S. Afr. j. physiother.

View full text Add to dashboard Cite

Background: There is growing concern about the long-term sequelae [a condition which is the consequence of a previous disease or injury] of perinatally acquired human immunodeficiency virus (HIV). Children living with HIV (CLHIV) present with cardiopulmonary impairments and decreased physical activity which may be due to poor endurance.Objectives: Our study aimed to investigate the sub-maximal endurance of CLHIV compared to a non-infected comparison group. Methods:In this cross-sectional descriptive study 346 CLHIV, between ages five and eleven years, were assessed using the Six Minute Walk Test (6MWT). Blood pressure, heart rate and oxygen saturation were measured pre-test, immediately post-test and five minutes post-test. Clinical and anthropometric data were recorded. Height and weight were assessed using a stadiometer and a digital scale, respectively.Results: 175 CLHIV (52% female) and 171 children without HIV (46% female) participated. All children were Black African. The CLHIV all initiated antiretroviral therapy (ART) at a young age (mean 8.7 months, standard deviation 6.7) and their disease was well controlled (viral load < 1000copies/ml). There were no statistically significant differences in submaximal endurance between the two groups (p = 0.831). Age of starting ART and stunted growth were negatively associated (r = -2.8 (p = 0.019) and r = -46.1 (p = 0.027), respectively) with distance walked in the 6MWT by girls living with HIV. Conclusion:CLHIV who initiate ART early with well-controlled disease are able to attain submaximal endurance levels similar to their uninfected peers. Clinical implications:Endurance and physical activity should be monitored in CLHIV. Submaximal endurance levels may improve with age and biological maturation.

show abstract

Effect of Structured Physical Activity on Inflammation and Immune Activation Profile of Antiretroviral Therapy-Experienced Children Living With HIV

Cited by 6 publications

References 43 publications

Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review

Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review

Moderate to Intense Physical Activity Is Associated With Improved Clinical, CD4/CD8 Ratio, and Immune Activation Status in HIV-Infected Patients on ART

Evaluation of submaximal endurance in young children living with HIV

Contact Info

Product

Resources

About