Effect of sub-chronic intraperitoneal administration of aminoguanidine on the memory and hippocampal apoptosis-related genes in diabetic rats

Alipour, Mohsen; Amini, Behnam; Adineh, Fatemeh; Feizi, Hadi; Mr, Jafari

doi:10.4149/bll_2016_092

Cited by 1 publication

(1 citation statement)

References 43 publications

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“…A recent study showed that Amg has protective effects against ovariectomy-induced memory defect and Aβ production disorder (22). Other studies have shown that one month of Amg injection improves memory by modulating Bcl-2 expression in diabetic rats (23,24). Asghari et al indicated that Amg reversed neuronal dysfunction and brain damage due to titanium dioxide and decreased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive neurons in the CA1 and other hippocampus regions (25).…”

Section: Introductionmentioning

confidence: 99%

Effects of Aminoguanidine on Apoptosis in the Hippocampus and Memory Disorder in a Rat Model of Alzheimer’s Disease

Sameni¹,

Vafaei²,

Zarbakhsh³

et al. 2021

Middle East J Rehabil Health Stud

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Background: Memory loss is the main disorder accompanied by Alzheimer's disease (AD). Objectives: We aimed to investigate the protective effects of aminoguanidine (Amg) on cell apoptosis in the hippocampal CA1 region and memory impairment in male rats received scopolamine (Scop). Methods: Thirty male Wistar rats (200 - 250 g) were randomly divided into the three groups of saline-saline group, Scop + saline, and Scop + Amg groups. The rats received intraperitoneal injection of Scop (3 mg/kg) for seven days, and subsequently, 100 mg/kg of Amg or normal saline were intraperitoneally administrated for 14 consecutive days. The Morris water maze test was used to study memory deficits. Finally, the animals were anesthetized, hippocampi were quickly removed, histological study was performed, and hippocampal cell apoptosis was evaluated by the cresyl violet staining and the terminal deoxynucleotidyl transferase dUTP nick end labeling test, respectively. Results: Scop injection resulted in reduced pyramidal cells and increased cell apoptosis in the hippocampal CA1 area, and impaired spatial learning and memory. The administration of Amg significantly improved memory and improved the density of pyramidal cells in the hippocampal CA1 area of the rats (P < 0.01). Also, the number of apoptotic cells in the CA1 region of the hippocampus in the Scop + Amg group decreased compared to the Scop + saline group (P < 0.05). Conclusions: These data demonstrate that the intraperitoneal injection of Amg declined the number of apoptotic cells in the CA1 area of the hippocampus and improved memory impairment in the Scop-induced rat model of AD. It is suggested that Amg may have protective effects against AD.

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