Effect of subcutaneous butylscopolamine administration in the reduction of peristaltic artifacts in 1.5-T MR fast abdominal examinations

Abstract

In abdominal MR imaging, ghost artifacts from noncyclic bowel movements can reduce the quality of the images. Although pharmacologic suppression of motion is effective, no study has being conducted to analyze the influence of drug motion suppression on fast breath-hold 1.5-T examinations of the upper abdomen. A prospective, randomized, doubleblind trial was conducted in 50 patients. Patients were randomly distributed into two groups: The control group received only an oral solution, whereas the other group received the oral solution plus a subcutaneous injection of 20 mg of butylscopolamine 10 min before the MR examination. Breath-hold T1-weighted gradientrecalled-echo (GRE) MR images were obtained in a 1.5-T superconductive unit. Quantitative image analysis was performed with regionof-interest (ROI) measurements of the signal intensity of the liver and in background air anterior and lateral to the patient. A qualitative analysis of the subjective quality of the T1weighted images was also done, and the adverse reactions were registered. The groups were homogeneous regarding age, gender, and weight dis-tribution. No significant differences in the signal intensity of the liver and in the incoherent noise measurements were found between the two groups. Gastrointestinal noise showed significant differences between groups, with lower values for the butylscopolamine group compared with the control group. There was also a statistically significant difference in the image quality between groups, and optimal studies were only found in the butylscopolamine group, where most patients had a good-quality evaluation. Regarding adverse events, there were non-significant differences between groups. In conclusion, administration of an antiperistaltic agent to reduce the movements of the gastrointestinal tract diminishes the motion artifacts generated on MR imaging of the abdomen, even at high field strength and with fast imaging sequences. Images of the upper abdomen obtained after pharmacologic suppression of the gastrointestinal movement are of significantly superior quality.

Uterine peristalsis and fertility: current knowledge and future perspectives: a review and meta-analysis

“…Anticholinergic agents are known to suppress smooth muscle activity in the bowel (Dosda et al, 2003;Tytgat, 2007). In addition, the anticholinergic agent hyoscine butylbromide (buscopan) also has a relaxing effect in the smooth muscle of the uterus (Daido et al, 2013;Nakai et al, 2008).…”

Effect of hyoscine butylbromide (HBB) on the uterine corpus: Quantitative assessment with T2‐weighted (T2W) MRI in healthy volunteers

“…HYOSCINE N‐BUTYLBROMIDE (HBB; Buscopan®, Boehringer Ingelheim, Ingelheim am Rhein, Germany) is used for the magnetic resonance imaging (MRI) of the female pelvis, because it suppresses contraction of smooth muscle in the intestine and reduces motion artifacts (1, 2). Similar to the intestine, muscular layer of the uterus, or myometrium, consists of smooth muscle, and therefore the uterus is known to have contractility.…”

Efficacy of butylscopolamine in obtaining clear MR image for intensity-modulated radiotherapy for prostate cancer

“…Diagnostic MR images are to examine invasion and metastasis around the organ; therefore, the field of view is wide. On the other hand, the reports from Dasda and Johnson showed that the administration of butylscopolamine is useful in the examination of pelvic MRI [11,12].…”