Effect of Subdepressor Clonidine on Flushing Reactions in Rosacea

Symptomatic treatment of idiopathic and rosacea-associated cutaneous flushing with propranolol

“…In another report, clonidine reduced malar temperature in patients with erythematotelangiectatic rosacea, despite the failure to reduce redness after provocative maneuvers. 5 Although b-blockers have also not demonstrated objective laboratory evidence for direct effects on cutaneous blood vessels during flushing episodes, some patients have reported fewer symptoms. 1,3,4 Single case reports exist for improvement of resistant flushing with thoracoscopic sympathectomy 6 and injection of botulinum toxin A.…”

“…[2][3][4] However, as opposed to the dermoscopic assessment of skin lesions in which melanin distribution and structure are examined directly at the site of origin, fewer details can be seen dermoscopically in the nail. 5 Examination of nail lesions is limited to the pigment that is deposited in the nail plate as a result of melanocytic activity that occurred in the nail matrix, bed, or both. Therefore, dermoscopic characteristics observed in the nail plate can misrepresent the underlying lesion.…”

<p>Conventional and Novel Treatment Modalities in Rosacea</p>

“…Although clonidine did not produce a major alteration in arterial blood pressure, it did not reduce flushing provoked by red wine, chocolate and hot weather, as well. 21 Cunliffe et al also investigated the effect of clonidine on flushing. Likewise, 0.05 mg clonidine hydrochloride was administered to patients twice daily.…”

Botulinum Toxin for the Treatment of Refractory Erythema and Flushing of Rosacea

“…Treatment of erythematotelangiectatic rosacea with severe facial flushing and persistent erythema remains challenging despite some successes with β-adrenergic blockers, clonidine (α-adrenergic agonist), naloxone (opiate antagonist), ondansetron (serotonin antagonist) and endoscopic thoracic sympathectomy [2,3,4,5,6]. …”