Effect of subdermal levonorgestrel contraceptive implants, NORPLANT®, on serum lipids

Shaaban, Mamdouh M.; Elwan, Sawsan I.; Abdalla, Shimaa; Darwish, Hebatallah A.

doi:10.1016/0010-7824(84)90033-7

Cited by 39 publications

(10 citation statements)

References 17 publications

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“…The results obtained in the present study with Norplant-2 (two rods) are similar to those observed by Shaaban et al [8] and Affandi et al [20] who reported no changes in total lipoproteins and triglycerides with Norplant (six .capsules).…”

Section: Discussionsupporting

confidence: 94%

“…Other workers have shown variable results, from no change to transient decrease in HDL-cholesterol with Norplant-2 [19] and increased HDL-cholesterol with Norplant [8].…”

Section: Discussionmentioning

confidence: 92%

“…With subdermal implants of R-2323, altered liver function tests were observed [6], but not with implants of other progestogens, including Norplant R (six capsules) [7,8].…”

Section: Introductionmentioning

confidence: 93%

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Short-term and long-term effects of NorplantR-2 on plasma lipoproteins and glucose tolerance

1991

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Twenty-five women using the levonorgestrel-containing contraceptive implant, Norplant-2, were studied longitudinally, to see the effects on lipid profile, glucose tolerance and hepatic transaminases with short-term (12 weeks) and long-term (18 to 24 months) use of Norplant-2 [corrected]. Total lipids, cholesterol, phospholipids, triglycerides and their subfractions were evaluated. There was a significant increase in LDL-cholesterol after 12 weeks of use (p less than 0.05), which did not persist at 18-24 months follow-up. The HDL-cholesterol, HDL/LDL-cholesterol ratio, phospholipids, other lipid fractions, hepatic transaminases and glucose tolerance did not alter significantly following short-term or long-term use of Norplant-2.

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Section: Discussionsupporting

confidence: 94%

“…Other workers have shown variable results, from no change to transient decrease in HDL-cholesterol with Norplant-2 [19] and increased HDL-cholesterol with Norplant [8].…”

Section: Discussionmentioning

confidence: 92%

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Short-term and long-term effects of NorplantR-2 on plasma lipoproteins and glucose tolerance

1991

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“…In a study comparing Norplant and intrauterine device (IUD) users, Croxatto's group (36) demonstrated a significant decrease in LDL levels in the Norplant users versus those using an IUD after 51 months of use. Shaaban and associates (41) found the same result after 12 months of use. The effect on HDL ranges from significant decrease (40) to no change (36) to a significant increase (35,41).…”

Section: Lipid Metabolismmentioning

confidence: 56%

“…The results have been inconsistent. Studies that look specifically at the effect of Norplant on lipid levels demonstrate a decrease in total cholesterol and total triglycerides (35,36,40,41). As mentioned earlier, an increase in triglycerides is a hallmark of lipid profiles in people with NIDDM.…”

Section: Lipid Metabolismmentioning

confidence: 99%