Effect of submicron and nano-iron oxide particles on pulmonary immunity in mice

Differential cellular responses in healthy mice and in mice with established airway inflammation when exposed to hematite nanoparticles

“…Hematite NP exposure induced a pro-inflammatory response in these mice, as indicated by the recruitment of innate immune cells such as neutrophils and eosinophils in the airways. This is in agreement with previous intratracheal/inhalation studies performed with other nanomaterials (Gustafsson et al, 2011;Rossi et al, 2010;Roursgaard et al, 2011;Ban et al, 2012). The rapid increase of lymphocytes, appearing in the BALF, is consistent with the previously reported lymphocyte dynamics in airways which is accountable for the rapid increase during toxic or allergic inflammation (Pabst and Tschernig, 1997).…”

Exposure characteristics of ferric oxide nanoparticles released during activities for manufacturing ferric oxide nanomaterials

“…Ferric oxide (Fe 2 O 3 ) NPs, which are mostly used in construction materials, paints, plastics, cosmetics and nutriments, are part of a list of nanomaterials that need to be tested [Organization for Economic Cooperation and Development (OECD, 2010)]. Several in vitro and in vivo studies on Fe 2 O 3 NPs have shown that the level of reactive oxygen series (ROS) increases, and hence inflammation, immunodepression, damage of the lung epithelium and disturbance of blood coagulation become more pronounced, with an increase in particle size and exposure dose (Ban et al, 2012(Ban et al, , 2013Guichard et al, 2012;Zhu et al, 2008Zhu et al, , 2011.…”

Value of phagocyte function screening for immunotoxicity of nanoparticles in vivo

“…94,112,118,119 The different results could be due to the use of different readouts (maturation and activation). Proinflammatory cytokine secretion [222][223][224] Proinflammatory cytokine secretion after inhalation 225 Decreased phagocytosis 12 Proinflammatory cytokine secretion after oropharyngeal application 226 Increased respiratory burst 227 Proinflammatory cytokine secretion after oral application 186 Decreased NO production 228 Neutrophilic granulocyte activation 117 Au Proinflammatory cytokine secretion 112,229,230 No increased cytokine secretion 110,111 No effect on DC maturation, no activation 94,112 Iron oxide Proinflammatory cytokine secretion after IT application 199,231 Proinflammatory cytokine secretion 232 Upon LPS challenge, decreased cytokine secretion after IT application 233 Decreased phagocytosis 234 Increased NO production with and without LPS challenge 233,234 No effect on DC maturation 94 SiO 2 Increased NO production after IT application 235 Proinflammatory cytokine secretion 13,236,237 Activation of DC 119 TiO 2 Proinflammatory cytokine secretion after IT application 235,238,239 Proinflammatory cytokine secretion 240 Proinflammatory cytokine secretion after IG application 10 Decreased chemotaxis …”