Effect of submucosal dexamethasone injections in the prevention of postoperative pain, trismus, and oedema associated with mandibular third molar surgery: a systematic review and meta-analysis

O’Hare, Phoebe Elizabeth; Wilson, B.; Loga, Mark George; Ariyawardana, Anura

doi:10.1016/j.ijom.2019.04.010

Cited by 44 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1.5 × 1.8 mL articaine with adrenaline 1:100,000 per side (total 2.5 × 1.8 mL per side; 5 × 1.8 mL per patient). An intramuscular injection of 8 mg of dexamethasone [16] (Laboratorio Farmacologico Milanese, Varese, Italy) was then provided to all patients just before the beginning of the surgical extractions in the masseteric region, dividing the 8 mg/2 mL ca. 50% per side.…”

Section: Methodsmentioning

confidence: 99%

Flapless Surgical Approach to Extract Impacted Inferior Third Molars: A Retrospective Clinical Study

Materni

Angelis

Tullio

et al. 2021

JCM

View full text Add to dashboard Cite

This study aimed to compare a flapless surgical approach (FSA) with a traditional envelope flap (traditional approach (TA)). Every patient was treated with two approaches: TA and FSA. The primary outcome variables were both the discomfort during the post-operative convalescence and the correct final recovery of the impacted area. The secondary outcome variable was the average duration of the surgery. Post-operative pain and oedema were recorded. The measurements of soft tissue interface toward the distobuccal edge of the second molar were taken by periodontal probe before surgery (baseline) and 8 weeks after surgery. Statistical software was used to evaluate the data; a p-value < 0.05 was considered statistically significant. Twenty-four teeth of 12 patients (six Caucasian males and six Caucasian females, aged 23 ± 4 (17–30) years) with both lower impacted third molars (Ms3) were analysed. Considering an alpha error 0.05 that sample size allows power from 0.80 to 0.90, depending on the variable evaluated. Concerning attached gingiva, oedema and pain, the linear mixed model resulted in a statistically significant difference between the TA and FSA (p = 0.003; p < 0.01; and p = 0.018, respectively). Conversely, the model did not show a difference (p = 0.322) if pocket probing depth was considered. The FSA procedure was faster (p < 0.05) than the TA procedure (17 min and 8 s (± 6 s) vs. 28 min and 6 s (± 4 s), respectively). The results suggest that the FSA could be a suitable option for improving the surgical removal of lower Ms3. However, additional randomized controlled trial studies are necessary to confirm the reliability of our procedure and to verify its suitability in more complex Ms3 classifications.

show abstract

Section: Methodsmentioning

confidence: 99%

Flapless Surgical Approach to Extract Impacted Inferior Third Molars: A Retrospective Clinical Study

Materni

Angelis

Tullio

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Ból występujący po usunięciu zęba różni się intensywnością między poszczególnymi pacjentami. Jego natężenie znacząco koreluje z rozległością urazu chirurgicznego [2], ponieważ miejscowe uszkodzenie kości i tkanek miękkich skutkuje uwolnieniem mediatorów zapalnych [20]. Ekstrakcje chirurgiczne, szczególnie zatrzymanych trzecich dolnych trzonowców, związane ze znoszeniem kości, osteotomią i separacją zęba, wywołują większy ból niż niepowikłane usunięcie zęba stałego [2], nie wspominając o zębach mlecznych, gdzieze względu na występujący zawiązek zęba stałego -po zabiegu nie łyżeczkuje się zębodołu [9,13].…”

Section: Różnice W Natężeniu Bólu Poekstrakcyjnegounclassified

“…Także śródzabiegowe podśluzówkowe podanie deksametazonu w dawce 4 mg jest klinicznie skuteczne w redukcji wczesnego bólu pozabiegowego oraz obrzęku, szczególnie w wypadku chirurgicznej ekstrakcji zatrzymanych dolnych trzecich trzonowców. Miejscowe deponowanie deksametazonu jest pozbawione skutków niepożądanych, charakterystycznych dla stosowania ogólnego glikokortykosteroidów drogą dożylną lub doustną [20].…”

Section: Strategie Postępowania W Bólu Poekstrakcyjnymunclassified

Postextractional pain management

Pasternak

Woroń

2020

Ból

View full text Add to dashboard Cite

Tooth extraction that is tooth removal is one of the most common surgical procedures in the dental practice. Like every surgical treatment tooth extraction is a tissue injury. Because during the procedure pain is controlled by the means of local or general anaesthesia post-procedural complaints are common, crucial, and inevitable problem. There is a varying degree of pain severity between patients depending on the level of complexity of the procedure – the pain reported after surgical extractions involving bone removal and tooth sectioning is significantly higher than in the cases of simple, uncomplicated tooth extraction. Intensity of pain is also higher in cases where the inflammation is present. In most cases the pain is acute in character and is usually localised to the extraction site, it can however affect the adjacent tooth on times. The inflammatory component together with mechanical trauma play a significant role in the etiology of postextractional pain. Alveolar osteitis, known as ‘dry socket’, is a special case of postprocedural complication with high pain intensity. The phenomenon relates to the blood clot resolution, which is the most optimal extraction wound dressing. In the paper pre-, intra- and postprocedural strategies were discussed, including general and local pharmacological actions and non-pharmacological actions including physical ones like cold compress and alternative methods like acupuncture, electroacupencture, transcutaneous nerve stimulation or conditioned pain modulation. Furthermore treatment of ‘dry socket’ a painful tooth removal complication was presented.

show abstract

“…Extraction of the mandibular third molar is one of the most commonly performed oral surgical procedures [1,2]. Because of the high degree of invasiveness when bone removal and crown division are involved, moderate to severe postoperative complications such as pain, swelling, di culty in opening and swallowing [2,3], and postoperative di culty in oral intake may occur.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ibuprofen Gargle for Postoperative Pain After Mandibular Third Molar Extraction: A Phase II, Placebo-Controlled, Double-Blind, Randomized Crossover Trial

Kakei¹,

Ioroi²,

Ito³

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundExtraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral administration of NSAIDs produces various adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical use of analgesics has been proposed as an alternative to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars in comparison with a placebo gargle.MethodsThis study will be performed at Kobe University Hospital. Participants (n = 40) will be randomized equally to one of two groups. The IP group will receive ibuprofen gargle on postoperative day (POD) 1 and placebo gargle on POD 2. The PI group will receive placebo gargle on POD 1 and ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargle on PODs 3 to 5 at least once daily. The primary objective is to estimate the within-subject difference in a visual analogue scale (VAS) before and 5 minutes after use of ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject difference in ΔVAS before and 15 minutes after use of ibuprofen or placebo gargle on PODs 1 and 2, the ΔVAS before and after 5 or 15 minutes of use of ibuprofen gargle on PODs 3 to 5, the overall effectiveness (self-completion, five scales) on PODs 1 to 5, the daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1 to 7, and the occurrence of adverse events.DiscussionThis will be the first well-designed clinical study to evaluate the efficacy of ibuprofen gargle for relieving postoperative pain after extraction of mandibular third molars. This trial will provide exploratory evidence of the efficacy and safety of ibuprofen gargle for pain reduction after mandibular third molar extraction.Trial registrationJapan Registry of Clinical Trials (jRCT) identifier: jRCTs051210022. Registered on 10 May 2021.

show abstract

Effect of submucosal dexamethasone injections in the prevention of postoperative pain, trismus, and oedema associated with mandibular third molar surgery: a systematic review and meta-analysis

Cited by 44 publications

References 33 publications

Flapless Surgical Approach to Extract Impacted Inferior Third Molars: A Retrospective Clinical Study

Flapless Surgical Approach to Extract Impacted Inferior Third Molars: A Retrospective Clinical Study

Postextractional pain management

Efficacy of Ibuprofen Gargle for Postoperative Pain After Mandibular Third Molar Extraction: A Phase II, Placebo-Controlled, Double-Blind, Randomized Crossover Trial

Contact Info

Product

Resources

About