Effect of Substance P and Sar⁹Met(O₂)¹¹-Substance P on Cutaneous Capillary Permeability in Guinea Pig Skin

Abstract

The purpose of this study was to assess the effect of several drugs on the increase in cutaneous capillary permeability induced by intradermal injection of substance P (SP) and Sar⁹Met(O₂)¹¹-SP in guinea pig skin. On the one hand, the increase in cutaneous capillary permeability was partly reduced by spantide, promethazine, atropine or SR 40037, an inhibitor of the angiotensin-converting enzyme. On the other hand, norepinephrine and B3824, a B₂-antagonist of bradykinin, showed an enhancing effect. Our results suggest that the effect of SP and Sar⁹Met(O₂)¹¹-SP in guinea pigs is partly mediated by histamine and acetylcholine, and that there is a relationship between tachykinins and bradykinin.