This work aimed to enhance the surface properties of common food packaging materials (PVC, PS, PET, PVDC) by applying a TiO 2 nano thin film coating. Physical and chemical analyses confirmed a well-defined anatase phase film. PET showed the highest antibacterial activity, followed by PVDC, PS, and PVC. After 60 min of UV-A irradiation, E. coli elimination rates were 99.85% (PET), 97.14% (PVDC), 96.5% (PS), and 85.91% (PVC). Similarly, for S. Typhimurium, the respective rates were 97.8% (PET), 83.71% (PVDC), 74.79% (PS), and 68.94% (PVC). Complete eradication of both strains occurred within 120 min (E. coli) and 180 min (S. Typhimurium). Durability testing revealed PET's mass loss of 97 mg/kg after 15 cycles, while PVC had the lowest value of 7 mg/kg. These findings demonstrate that TiO 2 thin film-coated substrates effectively inhibit bacteria growth, extending food product shelf life.