Effect of Subthalamic Nuclei Electrical Stimulation in the Treatment of Parkinson’s Disease

Abstract

The aim of this study was to evaluate the clinical efficacy of deep brain stimulation (DBS) and subthalamic nuclei stimulation (STN) in the treatment of Parkinson's disease. A total of 32 patients with Parkinson's disease who continuously treated in our hospital with STN-DBS from November 2011 to November 2013 were selected. All the patients received follow-up evaluation, psychological status questionnaire survey and analysis before surgery and 3 months after surgery using unified Parkinson's disease rating scale (UPDRS), Self-rating depression scale (SDS), and symptom checklist (SCL-90). After turned on the impulse generator (IPG), the daily activities and motor function of UPDRS in all the 32 cases of Parkinson's disease patients were in "turn off" state; the mean improvement rates were 51.7 and 60.9%; when the daily activities and motor function in the state of "turn on", the mean improvement rates were 21.4 and 22.3%. In 20 cases, the preoperative SDS > 50, the levels of depression, anxiety, somatization, interpersonal sensitivity, hostility, fear, and paranoia of SCL-90 were significant higher than the Chinese traditional levels (P < 0.05). Comparison of the preoperative and postoperative depression, somatization, fear, anxiety, and psychotic factor of SCL-90 found that there was negative correlation between preoperation and postoperation, and the differences were significant (P < 0.05), while there were no significant differences in interpersonal sensitivity and paranoia (P > 0.05). STN-DBS can improve the motor function and ability of daily life of Parkinson's disease patients and can significantly improve the psychological condition of the patients with Parkinson's disease and depression; it is a safe and effective method to the treatment of Parkinson's disease.

Association Between Somatization and Nonmotor Symptoms Severity in People With Parkinson Disease

“…10 On the other hand, a study by Tao et al on the effect of deep brain stimulation in PwP reported a preoperative SCL-90 SOM mean score of 2.66 ± 0.45, which improved to 1.69 ± 0.47 after surgery. 24 In our study, 43% of the PwP sample scored >1 in the SCL-90-R SOM, which is lower than previous reports. Consequently, the overall mean score of 0.91 was also lower compared to other studies.…”

Factors predicting the instant effect of motor function after subthalamic nucleus deep brain stimulation in Parkinson’s disease

“…Bilateral STN-DBS is widely used to treat PD and its distinct effects have been confirmed [2, 3, 6, 7, 11]. Compared with the “off-medication” condition prior to surgery, bilateral STN-DBS greatly improved the motor function of PD patients in “off-medication/on-stimulation” condition 3 months after surgery in our study.…”

“…Subsequently, bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) is used for patients with drug-refractory tremor or patients with intolerable motor complications. The benefits of STN-DBS are incontestable and have been proven by short-term and long-term follow-up studies [2–7]. …”

Clinical neurorestorative progress in Parkinson&#39;s disease

“…12 Furthermore, another study showed that DBS significantly improved psychological conditions, including depression, somatization, fear, anxiety, and psychosis, factors included in the symptoms checklist (SCL)-90, of patients with PD. 13 After DBS treatment, levodopa dose was reduced by about 54.5%. In contrast, levodopa dose was increased by 20.5% in the 36th month in the control group.…”