Effect of Succinylcholine on Intraocular Pressure in Human Beings

Schwartz, Herman; deROETTH, Andrew

doi:10.1097/00000542-195801000-00039

Cited by 23 publications

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“…Others have reported the absence of a relationship (Churchill-Davidson, 1954;Morris and Dunn, 1959;Lamoreaux and Urbach, 1960;Halldin and Palmer, 1961). The relationships between the magnitude of fasciculations and increased intraocular pressure (Schwartz and DeRoetth, 1958;Meyers et al, 1978) increased intragastric pressure (LaCour, 1970), arrhythmia (Winter and Ahnefeld, 1974) and electromyographic recordings (Collier, 1975) also remain controversial.…”

Section: Discussionmentioning

confidence: 99%

Suxamethonium Infusion Rate and Observed Fasciculations

Feingold¹,

Velazquez

1979

British Journal of Anaesthesia

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Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 mg was exceeded. Six additional patients received a 30-mg i.v. bolus dose. Fasciculations in six areas of the body were scored from 0 to 3 and summated as a total fasciculation score. The times to first fasciculation, twitch suppression and tetanus suppression were inversely related to the infusion rates. Fasciculations in the six areas and the total fasciculation score were related directly to the rate of infusion. Total fasciculation scores in the 30-mg bolus group and the 5-mg s-1 and 20-mg s-1 infusion groups were not significantly different.

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Section: Discussionmentioning

confidence: 99%

Suxamethonium Infusion Rate and Observed Fasciculations

Feingold¹,

Velazquez

1979

British Journal of Anaesthesia

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“…When succinylcholine is given in small doses the rise in tension depends on the size of the dose, but after a maximum rise has been attained, the dose size infhences only the duration of the raised tension (8,11,13). Yet, it is stated (16) that continuous drip of succinylcholine in combination with pentothal(thi0mebumalnatrium)-N;?O-O~ gives the same rise as a single dose, but the tension will fall again to basal values despite continued infusion. (Nothing is stated of the depth of the anaesthesia).…”

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confidence: 99%

Expulsive Haemorrhage Caused by Succinylcholine

Nørskov

1960

Acta Ophthalmologica

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Some cases have been reported previously of loss of vitreous ( 3 , 11) caused by succinylcholine injected after the eyeball had been incised. Below a case will be described in which a rise of the intra-ocular tension, produced by succinylcholine, is supposed to have been the releasing cause of an expulsive haemorrhage.Expulsive haemorrhage is a relatively rare phenomenon, of which nevertheless a number of cases have been described. Pau (15) collected 59 of these from the literature. Expulsive haemorrhage most often occurs in relation to glaucoma and cataract operations, but is generally stated to be a complication in somewhat less than a half per cent of the cases operated on.Numerous causes have been given of occurrence of expulsive haemorrhage. These are divided in predisposing and releasing factors. Among the former are: glaucoma, diabetes, hypertension, arteriosclerosis, excessive myopia, and congenital vascular abnormalities. Releasing factors may be a n increase of the intra-ocular tension due to sneezing, vomiting, coughing, >>squeezing(<, or errors of the operative technique. Great demands are made on the anaesthesia employed to counter these releasing factors.While formerly intra-ocular operations were most often made in local analgesia, general anaesthesia has been employed with advantage within recent years. For this purpose combinations of many anaesthetics have been used, and it is important to know the influence of the individual substances on the intraocular tension.Succinylcholine, used extensively as an aid in the intubation, among others, causes the intra-ocular tension to rise ( I , 3, 8, 11. 12, 13, 16, 18). Succinylcholine has a relaxing effect on striated muscles (except the extra-ocular muscles of the eye. See later). I t is generally classified as a depolarising drug acting on the motor end-plate in the same way as acetylcholine. However, the ") Received March 1st 1960.

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Ophthalmic Pharmacology and Toxicology

Roetth¹

1959

Archives of Ophthalmology

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Effect of Succinylcholine on Intraocular Pressure in Human Beings

Cited by 23 publications

References 0 publications

Suxamethonium Infusion Rate and Observed Fasciculations

Suxamethonium Infusion Rate and Observed Fasciculations

Expulsive Haemorrhage Caused by Succinylcholine

Ophthalmic Pharmacology and Toxicology

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