Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences

Kokavec, Anna

doi:10.1016/j.physbeh.2015.02.022

Cited by 8 publications

(13 citation statements)

References 50 publications

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“…Increased secretion of insulin after intake of carbohydrate and sucrose-rich meals may promote the occurrence of reactive hypoglycemia in some people, which may trigger migraine. 31 In this regard, 1 study 32 reported a higher level of plasma insulin in women with migraine compared with control participants.…”

Section: Potential Mechanismsmentioning

confidence: 97%

Associations Between Migraine and Type 2 Diabetes in Women

et al. 2019

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IMPORTANCE Little is known about the associations between migraine and type 2 diabetes and the temporality of the association between these 2 diseases. OBJECTIVE To evaluate the association between migraine and type 2 diabetes incidence as well as the evolution of the prevalence of active migraine before and after type 2 diabetes diagnosis. DESIGN, SETTING, AND PARTICIPANTS We used data from the E3N cohort study, a French prospective population-based study initiated in 1990 on a cohort of women born between 1925 and 1950. The E3N study participants are insured by a health insurance plan that mostly covers teachers. From the eligible women in the E3N study, we included those who completed the 2002 follow-up questionnaire with information available on migraine. We then excluded prevalent cases of type 2 diabetes, leaving a final sample of women who were followed up between 2004 and 2014. All potential occurrences of type 2 diabetes were identified through a drug reimbursement database. Statistical analyses were performed in March 2018. EXPOSURES Self-reported migraine occurrence. MAIN OUTCOMES AND MEASURES Pharmacologically treated type 2 diabetes. RESULTS From the 98 995 women in the study, 76 403 women completed the 2002 follow-up survey. Of these, 2156 were excluded because they had type 2 diabetes, leaving 74 247 women. Participants had a mean (SD) age of 61 (6) years at baseline, and all were free of type 2 diabetes. During 10 years of follow-up, 2372 incident type 2 diabetes cases occurred. A lower risk of type 2 diabetes was observed for women with active migraine compared with women with no migraine history (univariate hazard ratio, 0.80 [95% CI, 0.67-0.96], multivariable-adjusted hazard ratio, 0.70 [95% CI, 0.58-0.85]). We also observed a linear decrease in active migraine prevalence from 22% (95% CI, 16%-27%) to 11% (95% CI, 10%-12%) during the 24 years prior to diabetes diagnosis, after adjustment for potential type 2 diabetes risk factors. A plateau of migraine prevalence around 11% was then observed for 22 years after diagnosis. CONCLUSIONS AND RELEVANCE We observed a lower risk of developing type 2 diabetes for women with active migraine and a decrease in active migraine prevalence prior to diabetes diagnosis. Further targeted research should focus on understanding the mechanisms involved in explaining these findings.

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Section: Potential Mechanismsmentioning

confidence: 97%

Associations Between Migraine and Type 2 Diabetes in Women

et al. 2019

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“…Clinical evidence suggests that the consumption of sucrose can promote a significant elevation in serum insulin in fasted female migraine sufferers. However, while the level of serum insulin in female migraineurs was noted to be significantly higher than males and controls there was no evidence of sucrose-induced hyperinsulinism in any of the participants [114,113].…”

Section: Refined Sugar Productsmentioning

confidence: 70%

“…Summary of the reported psychological, nutritional, hormonal, behavioural and environmental migraine triggers [145,134,114,112,113,70].…”

Section: Tablementioning

confidence: 99%

“…However, when sucrose is combined with fat the level of insulin is potentiated and relatively low amounts of sucrose and fat can produce a significantly higher insulin response when compared to sucrose alone [84]. Therefore, while sucrose alone may not promote hyperinsulinism in migraineurs [113], food products such as chocolate, which contain a large amount of sucrose and fat [35], could potentiatie the level of plasma insulin further and promote the development of reactive hypoglycemia due to hyperinsulinism-induced insulin resistance. Furthermore, if we consider that chocolate also contains histamine [169], the relationship between chocolate-induced reactive-hypoglycemia and migraine becomes even more plausible.…”

Section: Refined Sugar Productsmentioning

confidence: 99%

“…The study of migraine is made difficult by the lack of an animal model that translates fully the clinical symptoms of migraine [188], the episodic nature of the attacks [1], and the observation that the migraine 'trigger' can be of nutritional, psychological, hormonal or behavioural origin [47,57,105,176,235,112,113]. To date, researchers have been unable to identify a set of triggers common to all migraineurs.…”

Section: Introductionmentioning

confidence: 99%

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Migraine: A disorder of metabolism?

Kokavec

2016

Medical Hypotheses

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The metabolic face of migraine — from pathophysiology to treatment

et al. 2019

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Migraine can be regarded as a conserved, adaptive response that occurs in genetically predisposed individuals with a mismatch between the brain's energy reserve and workload. Given the high prevalence of migraine, genotypes associated with the condition seem likely to have conferred an evolutionary advantage. Technological advances have enabled the examination of different aspects of cerebral metabolism in patients with migraine, and complementary animal research has highlighted possible metabolic mechanisms in migraine pathophysiology. An increasing amount of evidence-much of it clinical-suggests that migraine is a response to cerebral energy deficiency or oxidative stress levels that exceed antioxidant capacity and that the attack itself helps to restore brain energy homeostasis and reduces harmful oxidative stress levels. Greater understanding of metabolism in migraine offers novel therapeutic opportunities. In this Review , we describe the evidence for abnormalities in energy metabolism and mitochondrial function in migraine, with a focus on clinical data (including neuroimaging, biochemical, genetic and therapeutic studies), and consider the relationship of these abnormalities with the abnormal sensory processing and cerebral hyper-responsivity observed in migraine. We discuss experimental data to consider potential mechanisms by which metabolic abnormalities could generate attacks. Finally , we highlight potential treatments that target cerebral metabolism, such as nutraceuticals, ketone bodies and dietary interventions.

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Effect of sucrose consumption on serum insulin, serum cortisol and insulin sensitivity in migraine: Evidence of sex differences

Cited by 8 publications

References 50 publications

Associations Between Migraine and Type 2 Diabetes in Women

Associations Between Migraine and Type 2 Diabetes in Women

Migraine: A disorder of metabolism?

The metabolic face of migraine — from pathophysiology to treatment

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