Effect of sugar alcohol on colloidal stabilization of magnetic nanoparticles for hyperthermia and drug delivery applications

Tripling the Bioavailability of Rosuvastatin Calcium Through Development and Optimization of an In-Situ Forming Nanovesicular System

“…This might be due to the covering of the reconstituted nanovesicles by a dense layer of negatively charged hydroxyl groups belonging to mannitol. This was in harmony with the previous findings reported by Gawali et al, who studied the effect of mannitol on the stabilization of iron nanoparticles [51]. On the other hand, formulations loaded on Aerosil had weak negative charges despite silanol groups being present in its structure.…”

Characterization of an active ingredient made of nanoscale iron(oxyhydr)oxide for the treatment of hyperphosphatemia

“…All three organic educts used in our synthesis are known for their stabilizing effects on iron(oxyhydr)oxide nanoparticles. [26][27][28][29][30] In order to verify these effects on our substance, we examined the particle size and shape using dynamic light scattering (DLS), small-angle X-ray scattering (SAXS), and transmission electron microscopy (TEM). According to the DLS measurement, the particles have an average hydrodynamic diameter of 11.7 AE 1.1 nm, with most particles between 10 and 20 nm (cf.…”

“…Both components are known for their stabilizing effect on iron(oxyhydr)oxide nanoparticle sizes. [26][27][28] According to the authors' knowledge, the effect on the crystal structure has not been investigated for these substances yet. The combination of small molecules (mannitol) and longer polysaccharide chains (inulin) improves the protective function without steric hindrance between the coating molecules.…”

Recent development for biomedical applications of magnetic nanoparticles

“…These mannitol magnetic nanoparticles employ as carriers for doxorubicin hydrochloride delivery as an anticancer drug attached to the surface of these magnetic nanoparticles with negatively charged and doxorubicin positively charged in the delivery system by electrostatic interaction. The efficiency of loading was 60 % observed with sustained release and pH-dependent with self-healing abilities used in the therapy for hyperthermia [40] . However, the biocompatible MNPs in magnetic fluid hyperthermia used as mediators of heat in cancer therapy observe lower side effects and higher efficiencies [41] .…”