Effect of sulfate concentration on glycosaminoglycan synthesis in explant cultures of bovine articular cartilage

Hs, Brand; Vankampen, Gpj; Vandestadt, Rj; Kuijer, Roel; Vanderkorst, Jk

doi:10.1016/0309-1651(89)90061-1

Cited by 15 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…SH-Ammosäure-Mangel) auf das Serumsulfat da diese zu Hyposulfatämien führen können und nach Maroudas und Mitarbeiter (42) bei Konzentrationen <200 / untersulfatierte und damit minderwertige Proteoglycane bzw. Glycosaminoglycane im humanen Knorpel synthetisiert werden (2,24,31,34).…”

Section: Ergebnisse Und Diskussionunclassified

See 1 more Smart Citation

Einfache turbidimetrische Mikrolitermethode zur Bestimmung der Sulfationenkonzentration im Serum und Urin – Referenzwerte, Stoffwechsel und diagnostische Bedeutung.

Dressler¹

1993

LaboratoriumsMedizin

View full text Add to dashboard Cite

A new and simple turbidimetric microliter method for the determination of the sulfate concentration in serum and urine is described. For the sulfate precipitation 4-chloro-4'aminodiphenyl is used and the turbidity can be detected with a photometer. Resufts of the precision, recovery and reference values are described and the diagnostic relevance of sulfate (renal disease, synthesis of proteoglycane/glycosaminoglycane, and biotransformation) is discussed.

show abstract

Section: Ergebnisse Und Diskussionunclassified

“…Chondroitinsulfat-und mehr nichtsulfatierte Chondroitin-Ketten(2,23,24,27,28, 31, 32, 34,42,68,70). Laboratorien, auf Grund der notwendigen Spezialtechnik sowie des zum Teil hohen Arbeits-und Zeitaufwandes nur wenig geeignet.…”

unclassified

Einfache turbidimetrische Mikrolitermethode zur Bestimmung der Sulfationenkonzentration im Serum und Urin – Referenzwerte, Stoffwechsel und diagnostische Bedeutung.

Dressler¹

1993

LaboratoriumsMedizin

View full text Add to dashboard Cite

show abstract

The Proteoglycan Metabolism of Mature Bovine Articular Cartilage Explants Superimposed to Continuously Applied Cyclic Mechanical Loading

Steinmeyer

Knue

1997

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

Bovine sesamoid bones: A culture system for anatomically intact articular cartilage

Korver

Stadt

Kampen

et al. 1989

In Vitro Cell Dev Biol

View full text Add to dashboard Cite

Medial sesamoid bones from the metacarpophalangeal joints of calves were used for prolonged culture of anatomically intact articular cartilage on its natural bone support. The cartilage remained viable during culture, without signs of degeneration. After 1 wk of culture the cartilage showed an increased proteoglycan synthesis, and some minor changes in the composition of newly synthesized proteoglycans were observed. In the next 7 wk all studied parameters remained constant, except for the rate of proteoglycan synthesis, which declined between 4 and 8 wk to values just below those measured at the start of culture. Despite the fact that newly synthesized proteoglycans showed some altered biochemical properties, the composition of the total pool of proteoglycans did not change during 8 wk of culture. The significance of this phenomenon is discussed. This new in vitro model of intact articular cartilage offers a promising alternative to in vivo studies because in contrast to other in vitro models no surgical injury of the cartilage is introduced.

show abstract

Effect of sulfate concentration on glycosaminoglycan synthesis in explant cultures of bovine articular cartilage

Cited by 15 publications

References 21 publications

Einfache turbidimetrische Mikrolitermethode zur Bestimmung der Sulfationenkonzentration im Serum und Urin – Referenzwerte, Stoffwechsel und diagnostische Bedeutung.

Einfache turbidimetrische Mikrolitermethode zur Bestimmung der Sulfationenkonzentration im Serum und Urin – Referenzwerte, Stoffwechsel und diagnostische Bedeutung.

The Proteoglycan Metabolism of Mature Bovine Articular Cartilage Explants Superimposed to Continuously Applied Cyclic Mechanical Loading

Bovine sesamoid bones: A culture system for anatomically intact articular cartilage

Contact Info

Product

Resources

About