Effect of supersaturation and crystallization phenomena on the release properties of a controlled release device based on EVA copolymer

Effect of orotic acid as a nucleating agent on the crystallization of bacterial poly(3‐hydroxybutyrate‐co‐3‐hydroxyhexanoate) copolymers

“…This restriction simultaneously retards the two reactions, which causes the Cu 2+ release rate of the microcomposite to be less than that of the nanocomposite as illustrated in Figure 2. The nondissolvable products, such as CuCO 3 · Cu(OH) 2 and CaCO 3, which form on the surface of microparticles during the long term of corrosion in the SUS,13 further retard the corrosion reactions. This retardation ultimately results in the decrease of the Cu 2+ release rate of the microcomposite after incubation for about 150 days.…”

“…In view of these defects, we considered substituting the conventional IUD with the nanocomposite, which is a combination of some unique properties of nanomaterials and the controlled release of polymer matrix composites 12, 13. The results indicate that the effect of copper nanoparticle size could increase the Cu 2+ transformation ratio in a simulated uterine solution (SUS), which was prepared according to the composition of human uterine solution 14.…”

Compositional Analysis of Low Quantities of Phase Separation in Hot-Melt-Extruded Solid Dispersions: A Combined Atomic Force Microscopy, Photothermal Fourier-Transform Infrared Microspectroscopy, and Localised Thermal Analysis Approach

“…On extrusion, the drug and polymer may form an intimate (molecular level) mix due to the application of a combination of heat and shear pressure. However, if the amount of drug in the polymer exceeds its equilibrium solid solubility, the drug either separates or else may be in a thermodynamically unstable supersaturated state after extrusion (4,5), leading to long-term stability issues such as drug crystallisation. In most cases, phase separation is undesirable and is considered to lead to potentially significant Electronic Supplementary Material The online version of this article (doi:10.1007/s11095-011-0461-2) contains supplementary material, which is available to authorized users.…”

Solubility of Pharmaceutical Solids

“…Pharmaceutical applications of solid dispersions have become increasingly important over the last few decades in helping to overcome delivery challenges of poorly water soluble drugs (Chiou and Riegelman, 1971;Sheen et al, 1991;Serajuddin, 1999;Khoo et al, 2000;van Laarhoven et al, 2002;Verreck et al, 2004). The ideal type of solid dispersion for increasing dissolution is a glassy solution, in which the drug in the amorphous form has a lower thermodynamic barrier to dissolution and a maximally reduced particle size (Goldberg et al, 1965).…”