Effect of Supervised Progressive Resistance-Exercise Training Protocol on Insulin Sensitivity, Glycemia, Lipids, and Body Composition in Asian Indians With Type 2 Diabetes

Abstract

OBJECTIVE -To evaluate the effect of supervised progressive resistance-exercise training (PRT) protocol on insulin sensitivity, glycemia (blood glucose and A1C levels), lipids, and body composition in Asian Indians with type 2 diabetes.RESEARCH DESIGN AND METHODS -Thirty patients with type 2 diabetes underwent 12 weeks of PRT of six muscle groups (two sets, 10 repetitions each). The subjects were evaluated with detailed anthropometry and with measurements of the disappearance of glucose per unit time (K) during the short insulin tolerance test (K ITT ) for assessment of insulin sensitivity; of fasting blood glucose, A1C, lipids, and high-sensitivity C-reactive protein (hsCRP); of total body fat, regional fat, and lean body mass by dual-energy X-ray absorptiometry; and of cross-sectional skeletal muscle area of upper arm and thigh by computed tomography scan.RESULTS -Insulin sensitivity improved significantly from mean Ϯ SD K ITT 1.22 Ϯ 0.73 to 2.13 Ϯ 0.75 (P Ͻ 0.0001) after the intervention. Significant decline (mean difference Ϯ SD) from baseline was recorded in levels of the following parameters: A1C (0.54 Ϯ 0.4%, P Ͻ 0.001), fasting blood glucose (2.7 Ϯ 2.2 mmol/l, P Ͻ 0.001), total cholesterol (0.39 Ϯ 0.7 mmol/l, P ϭ 0.003), serum triglycerides (0.39 Ϯ 0.5 mmol/l, P Ͻ 0.001), and truncal and peripheral subcutaneous adipose tissue compartments (SCAT) (P Ͻ 0.001). However, no significant changes were noticed in BMI or levels of total body fat, truncal fat, lean body mass, cross-sectional skeletal muscle area of the extremities, or hsCRP levels.CONCLUSIONS -Moderate-intensity PRT for 3 months resulted in significant improvement in insulin sensitivity, glycemia, lipids, and truncal and peripheral SCAT in patients with type 2 diabetes. Resistance training should be an integral part of exercise regimen in Asian Indians with type 2 diabetes.

The Effect of Interval Training and Nettle Supplement on Glycemic Control and Blood Pressure in Men WithType 2 Diabetes

“…Our findings on the effect of exercise on blood sugar were similar with previous findings. 5,21,[26][27][28][29][30] Nevertheless, results of a study by Karstoft et al differed from our findings. 31 These differences may be due to the participant's characteristics.…”

Effectiveness of physical activity and dietary interventions in South Asian populations: a systematic review

“…9,10 Several reviews on the effects of diet and exercise on the incidence of CHD and type 2 diabetes have emphasised their importance in the primary and secondary prevention of disease. [11][12][13] With South Asian populations identified as less physically active than the general population, 14,15 alongside growing concern about child and adult obesity, 16 culturally appropriate and effective interventions in this high-risk group are urgently needed. 17 However, little is known about relevant experience of such interventions with South Asian populations.…”

The Effect of Supervised Progressive Resistance Training (PRT) on Glycemic Control and Cardio Vascular Disease (CVD) Risk Markers in Type 2 Diabetes Patients, North West Ethiopian

“…A similar study conducted on Asian Indians with Type 2 Diabetes showed that a moderate-intensity PRT for 3 months resulted in a significant improvement in insulin sensitivity, glycemia, lipids, and truncal and peripheral SCAT in patients with Type 2 DM, but no significant changes were noticed in BMI or levels of total body fat, truncal fat, and lean body mass [15]. However, in our study there were significant improvements in muscle and bone density as well as reductions in body fat percentage and visceral fat which were positively related to reductions in FBG total cholesterol level.…”