2004
DOI: 10.1111/j.1525-1497.2004.30090.x
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Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease

Abstract: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

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Cited by 152 publications
(104 citation statements)
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“…In the National Health and Nutrition Examination Survey iv trial, levels of highsensitivity C-reactive protein, an inflammatory marker, were inversely related to the levels of serum antioxidant micronutrients including Se [179]. However, results of antioxidant supplementation trials have largely been disappointing, demonstrating little effect of Se and vitamins E and C on gastric cancer [180] and no effect of vitamin E and β-carotene on the prevention of heart disease [181]. Some randomized, controlled trials have actually displayed adverse effects of supplementation with antioxidants such as β-carotene and vitamins E or A on lung cancer and heart disease [118,182,183], demonstrating a need for caution.…”
Section: History Of Clinical Trials Of Antioxidants In Other Diseasesmentioning
confidence: 99%
“…In the National Health and Nutrition Examination Survey iv trial, levels of highsensitivity C-reactive protein, an inflammatory marker, were inversely related to the levels of serum antioxidant micronutrients including Se [179]. However, results of antioxidant supplementation trials have largely been disappointing, demonstrating little effect of Se and vitamins E and C on gastric cancer [180] and no effect of vitamin E and β-carotene on the prevention of heart disease [181]. Some randomized, controlled trials have actually displayed adverse effects of supplementation with antioxidants such as β-carotene and vitamins E or A on lung cancer and heart disease [118,182,183], demonstrating a need for caution.…”
Section: History Of Clinical Trials Of Antioxidants In Other Diseasesmentioning
confidence: 99%
“…Several reviews and meta-analyses have recently concluded that, for most forms of oxidative-stress-related diseases tested so far, there is no beneficial effect of supplemental a-tocopherol or, probably, of supplemental b-carotene and ascorbic acid (Vivekananthan, 2003;Eidelman et al 2004;Shekelle et al 2004). The results of intervention studies using supplements of selenium, which is not an antioxidant itself but an essential building block of the endogenous antioxidant defence, are more positive, however (Bjelakovic et al 2004;Etminan et al 2005).…”
Section: Dietary Compounds With the Ability To Directly Scavenge Or Nmentioning
confidence: 99%
“…It is not the intention of the paper to summarize the individual trials in detail again. For this, the reader is referred to recent comprehensive reviews [12,33,43,63,69]. Instead, the paper will focus on very recent trials and meta-analyses summarising adverse effects of atocopherol supplementation in patients.…”
Section: Introductionmentioning
confidence: 99%