Effect of supplementary omega-3 fatty acids on pregnant women with complications and pregnancy outcomes: review from literature

Chowdhury, Mohammad Hasan; Susmita, Ghosh; Kabir, Ruhul; Mamun, Abdullah Al; Islam, Shahedul

doi:10.1080/14767058.2020.1786522

Cited by 5 publications

(3 citation statements)

References 63 publications

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“…In the fetus and newborn, the capacity for the elongation and desaturation of EFAs is insufficient, and consequently, maternal LCPUFA status during pregnancy and lactation becomes critical to allow for the appropriate availability of LCPUFAs to the fetus and newborn infants [ 95 , 114 , 115 ]. Despite several controlled trials having been carried out to determine whether dietary LCPUFA supplements during different perinatal stages can improve the development outcome, no definitive conclusions have been reached [ 7 , 116 , 117 ], but some specific comments deserve mention.…”

Section: Dietary Fatty Acid During Pregnancy and Lactationmentioning

confidence: 99%

Dietary Implications of Polyunsaturated Fatty Acids during Pregnancy and in Neonates

Herrera,

Ortega-Senovilla

2023

Life

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Certain limitations exist for animals to modify fatty acid changes. Besides the role of arachidonic acid (AA), docosahexaenoic acid (DHA) and other 20-carbon long-chain polyunsaturated fatty acids (LCPUFAs) for the synthesis of inflammatory mediators as eicosanoids, different LCPUFAs have many other effects, including their abilities to regulate gene expression and downstream events. LCPUFAs are susceptible to autoxidation, which is prevented by the action of antioxidants in the form of enzymes like superoxide dismutases, catalases and peroxidases, as well as antioxidant compounds that protect against oxidation or repair the damage caused. Under normal conditions, the fetus needs both essential fatty acids (EFAs) and LCPUFAs, which are obtained from its mother by placental transfer. In early pregnancy, dietary derived fatty acids are accumulated in maternal adipose tissue. However, during late pregnancy, corresponding to the period of the highest fetal growth, maternal adipose tissue becomes catabolic and LCPUFAs are released into the circulation by adipose lipolytic activity. The released LCPUFAs are taken up by maternal liver to be esterified and released back to the circulation as triacylglycerides (TAGs) in very-low-density lipoprotein (VLDL) that become available to the placenta to be transferred to the fetus in the form of non-esterified fatty acids (NEFAs). An enhanced adipose tissue lipolysis is maintained around parturition and esterified LCPUFAs are diverted to mammary glands thanks to an increased activity of lipoprotein lipase for milk production. Throughout this process, LCPUFAs become available to the newborn during suckling. The important role of both DHA and AA for the development of the nervous system and for growth has motivated their dietary supplement during different postnatal stages. This has been especially important in preterm infants both because under normal conditions, the fetus acquires most of these fatty acids during late pregnancy, and because the immaturity of the enzyme systems for the synthesis of AA and DHA from their respective EFAs.

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Section: Dietary Fatty Acid During Pregnancy and Lactationmentioning

confidence: 99%

Dietary Implications of Polyunsaturated Fatty Acids during Pregnancy and in Neonates

Herrera,

Ortega-Senovilla

2023

Life

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“…In addition to the clustering analysis, correlation analysis is utilized to examine the association between physicochemical properties and wound-healing activities of the peptides. A common method of correlation analysis is the Pearson correlation coefficient, which quantifies the linear relationship between two variables [97]. The correlation coefficient is calculated between each pair of physicochemical properties and wound-healing activities.…”

Section: Statistics and Classification Of Wound-healing Peptidesmentioning

confidence: 99%

Characterization and Classification In Silico of Peptides with Dual Activity (Antimicrobial and Wound Healing)

Trejos,

Aristizabal,

Aragón-Muriel

et al. 2023

IJMS

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The growing challenge of chronic wounds and antibiotic resistance has spotlighted the potential of dual-function peptides (antimicrobial and wound healing) as novel therapeutic strategies. The investigation aimed to characterize and correlate in silico the physicochemical attributes of these peptides with their biological activity. We sourced a dataset of 207 such peptides from various peptide databases, followed by a detailed analysis of their physicochemical properties using bioinformatic tools. Utilizing statistical tools like clustering, correlation, and principal component analysis (PCA), patterns and relationships were discerned among these properties. Furthermore, we analyzed the peptides’ functional domains for insights into their potential mechanisms of action. Our findings spotlight peptides in Cluster 2 as efficacious in wound healing, whereas Cluster 1 peptides exhibited pronounced antimicrobial potential. In our study, we identified specific amino acid patterns and peptide families associated with their biological activities, such as the cecropin antimicrobial domain. Additionally, we found the presence of polar amino acids like arginine, cysteine, and lysine, as well as apolar amino acids like glycine, isoleucine, and leucine. These characteristics are crucial for interactions with bacterial membranes and receptors involved in migration, proliferation, angiogenesis, and immunomodulation. While this study provides a groundwork for therapeutic development, translating these findings into practical applications necessitates additional experimental and clinical research.

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“…n-3 LCPUFAs, which are found in fish oils, may have beneficial effects in pregnancy; however, at present, data are insufficient to recommend omega-3 fatty acid supplementation for the sole purpose of reducing the risk of preterm birth or preventing perinatal depression 11,12 . However, it is possible that certain subgroups of women, such as those who smoke cigarettes, may be more likely to benefit from supplementation than others 12,13 . We and others have found that red blood cell phospholipid (RBC) membrane concentrations of the n-3 LCPUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are significantly reduced in smokers compared to nonsmokers [14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

The Fish Oil to Reduce Tobacco Use iN Expectant mothers (FORTUNE) feasibility trial

Murff¹,

Greevy²,

STERNLIEB³

et al. 2022

American Journal of Obstetrics & Gynecology MFM

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Effect of supplementary omega-3 fatty acids on pregnant women with complications and pregnancy outcomes: review from literature

Cited by 5 publications

References 63 publications

Dietary Implications of Polyunsaturated Fatty Acids during Pregnancy and in Neonates

Dietary Implications of Polyunsaturated Fatty Acids during Pregnancy and in Neonates

Characterization and Classification In Silico of Peptides with Dual Activity (Antimicrobial and Wound Healing)

The Fish Oil to Reduce Tobacco Use iN Expectant mothers (FORTUNE) feasibility trial

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