Effect of supplementation of a mixture of gluconeogenic precursors during the transition period on performance, blood metabolites and insulin concentrations and hepatic gene expression of dairy cows

Rivas, Ruth M. Orellana; Gutierrez-Oviedo, Fabian; Komori, Gustavo H.; Beihling, V.V.; Marins, Thiago N.; Azzone, John; Bernard, J.K.; Tao, Sha

doi:10.1016/j.anifeedsci.2020.114791

Cited by 4 publications

(6 citation statements)

References 39 publications

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“…Oba and Allen [29] reported that propionate infusion linearly increased plasma insulin and glucose concentrations for early lactation. But the results of Rivas et al [30] did not observe the supplement of gluconeogenic precursors (containing propylene glycol, glycerol, and calcium propionate, et al) during the transition changed the plasma glucose, BHBA, NEFA, and insulin. We also did not observe signi cantly difference in serum glucose, BHBA and insulin may be attribute to the effect of calcium propionate in stimulating milk yield, which improve the requirement of energy.…”

Section: Blood Parameters Related To Neb and Calcium Homeostasismentioning

confidence: 89%

Effects of Calcium Propionate on Milk Performance and Serum Metabolome of Dairy Cows in Early Lactation

Zhang

Zhao

Wang

et al. 2021

Preprint

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Background: Most of the dairy cows in early lactation suffer from a period of negative energy balance (NEB) and hypocalcemia metabolic disorders. Calcium propionate is a source of energy and calcium for alleviating NEB and hypocalcemia. The objective of the study was to investigate the changes of milk compositions and blood metabolites of postpartum dairy cows fed with calcium propionate for 5 weeks.Methods:Thirty-two multiparous Holstein cows after calving were randomly allocated to control (CON), low calcium propionate (LCaP), medium calcium propionate (MCaP) and high calcium propionate (HCaP) groups with 8 cows per group balanced with parity, milk yield and body weight. The dairy cows in the four groups were oral drenching with 0, 200, 350, 500 g/d calcium propionate per cow from calving to d 35 in early lactation, respectively.Results:The results showed that the milk yield in MCaP group was significantly higher than those in the other groups. At d 35, the somatic cell count (SCC) in MCaP group tended to be lower than those in other groups. Compared with the CON group, serum non-esterified fatty acid (NEFA) in MCaP and HCaP groups tended to decrease. The serum alanine aminotransferase (ALT) concentration in MCaP group was lowest among the four groups. The concentration of aspartate aminotransferase (AST) in HCaP group was significantly higher than the other groups. Feeding calcium propionate had no significant effect on serum calcium, phosphorus and magnesium concentrations. The serum parathyroid hormone (PTH) in HCaP group tended to decrease. The calcium propionate treatments significantly decreased the serum alkaline phosphatase (ALP) level. The MCaP treatment significantly decreased serum total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activity, while increased the concentration of malondialdehyde (MDA) when compared with the other groups. The metabolomic results showed that calcium propionate significantly affected the bile acid compositions. Conclusions: It was concluded that the 350 g/d calcium propionate feeding level could significantly improve milk performance, alleviate body fat mobilization and bone calcium utilization, however decrease antioxidant capacity of dairy cows as well. The effect of calcium propionate on milk performance and serum metabolites in early lactation cows may be regulated through the serum bile acids metabolism.

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Section: Blood Parameters Related To Neb and Calcium Homeostasismentioning

confidence: 89%

Effects of Calcium Propionate on Milk Performance and Serum Metabolome of Dairy Cows in Early Lactation

Zhang

Zhao

Wang

et al. 2021

Preprint

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“…High-producing dairy cows are at high risk for severe NEB [23]. It has previously been reported that feeding with calcium propionate [10] or gluconeogenic precursors [24] does not affect DMI. In the current study, however, the DMI increased quadratically with the Milk KEGG pathway analysis of differential metabolites in the pairwise comparisons of LCaP compared to CON (A), MCaP compared to CON (B), HCaP compared to CON (C), and MCaP compared to HCaP (D).…”

Section: Animal Performancementioning

confidence: 99%

Alterations in the Milk Metabolome of Dairy Cows Supplemented with Different Levels of Calcium Propionate in Early Lactation

et al. 2022

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This study aimed to investigate the effects of dietary supplementation with different levels of calcium propionate on the lactation performance, blood energy metabolite parameters, and milk metabolites of dairy cows in early lactation. Thirty-two multiparous Holstein cows were randomly divided into 4 groups, which were orally drenched with 0, 200, 350, and 500 g/d calcium propionate per cow supplemented to a basal diet for 5 weeks from calving. The milk and blood of the dairy cows were sampled and measured every week. The milk samples from the last week were used for the metabolomic analysis via liquid chromatography–mass spectrometry (LC-MS). The results showed that the calcium propionate supplementation quadratically increased the dry matter intake, energy-corrected milk yield, and 4% fat-corrected milk yield; linearly reduced the milk protein and milk lactose concentrations; and quadratically decreased the somatic cell count in the milk. With the increase in calcium propionate, the serum glucose content showed a linear increase, while the serum insulin content showed a quadratic increase. The diets supplemented with calcium propionate quadratically decreased the β-hydroxybutyric acid and linearly decreased the non-esterified fatty acid content in the serum. The metabolomic analysis revealed that eighteen different metabolites were identified in the milk samples of the dairy cows supplemented with calcium propionate at 350 g/d, which decreased the abundance of genistein and uridine 5-monophosphate and increased the abundance of adenosine, uracil, protoporphyrin IX, and sphingomyelin (d 18:1/18:0) compared with the control group. The milk metabolic analysis indicated that the calcium propionate effectively improved the milk synthesis and alleviated the mobilization of adipose tissue and bone calcium. In summary, the calcium propionate could improve the lactation performance and energy status and promote the milk metabolic profile of dairy cows in early lactation. Calcium propionate (350 g/d) is a well-recommended supplement for dairy cows for alleviating negative energy balance and hypocalcemia in early lactation.

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“…Por ejemplo, en bovinos se puede incluir en un rango de 50 a 300 g/d (6,7,8) y en ovinos en crecimiento de 10 a 30 g/kg de MS (9,10). El potencial gluconeogénico del PCa permite contrarrestar los efectos del balance energético negativo y cetosis que ocurre al inicio de la lactancia en vacas lecheras (11), cuando las necesidades energéticas para la síntesis láctea no se satisfacen con la dieta (12). También se ha utilizado para mejorar el aumento de peso corporal en terneros y favorecer el desarrollo de los órganos internos y tracto gastrointestinal (13).…”

Section: Introductionunclassified

Productividad y características de la canal de ovinos suplementados con propionato de calcio

et al. 2024

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Objetivo. Evaluar el efecto de la inclusión de propionato de calcio (PCa) sobre variables productivas y características de la canal en corderos en finalización. Materiales y métodos. Se utilizaron 24 coderos machos de la cruza Dorper*Pelibuey de 5 meses de edad, con un peso corporal promedio (μ±SD) de 27±2.7. Fueron asignados a uno de tres tratamientos [control (CON) y dos niveles de PCa: 10 y 20 g/kg de MS] en un diseño completamente al azar (3 tratamientos, 8 repeticiones por tratamiento, considerando cada cordero como una unidad experimental). Las variables de respuesta se redujeron a 1 valor medio para cada cordero, y los datos se analizaron en SAS versión 9.4 usando Proc Mixed. Resultados. La ganancia diaria de peso (GDP), conversión (CA) y eficiencia alimenticia (EF) fueron mayores en 13, 20 y 24%, respectivamente por la inclusión de 20 g PCa/kg MS (p≤0.05). El peso de la canal fría (PCF), rendimiento en canal caliente (RCC) y rendimiento en canal fría (RCF) fueron mayores al incrementar el nivel de inclusión de PCa (p≤0.05). Conclusiones. La suplementación con PCa en dosis de hasta 20g/kg en dietas de finalización puede mejorar los parámetros productivos y de rendimiento en canal sin afectar el consumo de materia seca (DMI).

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Effect of supplementation of a mixture of gluconeogenic precursors during the transition period on performance, blood metabolites and insulin concentrations and hepatic gene expression of dairy cows

Cited by 4 publications

References 39 publications

Effects of Calcium Propionate on Milk Performance and Serum Metabolome of Dairy Cows in Early Lactation

Effects of Calcium Propionate on Milk Performance and Serum Metabolome of Dairy Cows in Early Lactation

Alterations in the Milk Metabolome of Dairy Cows Supplemented with Different Levels of Calcium Propionate in Early Lactation

Productividad y características de la canal de ovinos suplementados con propionato de calcio

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