Effect of Supplementation of Fruit Extract (Cranberrry, Blueberry and Pomegranate) on Insulin Resistance and Oxidative Stress in Hypertensive Patients

Beneficial effects of blueberry supplementation on the components of metabolic syndrome: a systematic review and meta-analysis

“…The main characteristics of the 26 clinical trials conducted on hypertensive, normotensive, MetS, smoker, non-smoker and healthy subjects are summarized in Table 1. These studies were conducted in Asia, [58][59][60] Europe, 15,44,[61][62][63][64] the USA, [65][66][67][68][69][70][71][72][73][74][75][76][77][78] South America, 79 Canada 80 and North America, 81 and pub-lished between 2010 and 2021. Twenty trials had a parallel study design 44,59,60,[63][64][65][66][67][68][69][70][71][73][74][75][76][77][78]80,81 and 6 trials had a crossover study design.…”

“…Twenty trials had a parallel study design 44,59,60,[63][64][65][66][67][68][69][70][71][73][74][75][76][77][78]80,81 and 6 trials had a crossover study design. 15,58,61,62,72,79 The studies used different preparations of blueberry that included blueberry extract, 60,62,63,66,71 freeze-dried blueberry, 15,44,64,65,67,69,70,[73][74][75][76][77]80 frozen blueberry, 59,61 blueberry beverages, 58 smoothies, 68 blueberry juice 72 and fruit extract capsules. 79 Furthermore, blueberry dosage var...…”

“…15,58,61,62,72,79 The studies used different preparations of blueberry that included blueberry extract, 60,62,63,66,71 freeze-dried blueberry, 15,44,64,65,67,69,70,[73][74][75][76][77]80 frozen blueberry, 59,61 blueberry beverages, 58 smoothies, 68 blueberry juice 72 and fruit extract capsules. 79 Furthermore, blueberry dosage varied among different studies and was between 300 mg and 45 g. Study durations were different and varied Food & Function Review between 3 weeks and 6 months. The number of participants in these trials ranged from 10 to 138.…”

“…According to this scale, eight studies received a score of 6, 44,58,63,65,67,70,72,80 four studies received a score of 4, 64,74,76,77 two studies received a score of 5, 68,75 six studies received a score of 3 15,61,62,69,71,73 and six studies scored 2. 59,60,66,78,79,81 Scores of 5 and 6 were considered high evidence quality, 3 moderate evidence quality and 2 low evidence quality. So the majority of the human studies were moderate to high evidence quality.…”

“…81 In the study carried out by Gaeta et al, it was revealed that taking daily fruit extract capsules containing blueberry for 4 weeks did not affect body mass index significantly ( p > 0.05). 79 Waist circumference. Six studies (listed in Fig.…”