Effect of Supplementation of Traditional Medicinal Plants on Serum Lipid Profile in Non-Insulin Dependent Diabetics

Kochhar, Anita; Nagi, Malkit; Sachdeva, Rajbir

doi:10.1080/09709274.2007.11905996

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…This would definitely reduce the incidence of coronary events being the major cause of morbidity and deaths in diabetes subjects (Singh et al, 2007). HDL-C transports cholesterol from peripheral tissues to the liver, thereby reducing the amount stores in tissue and decreasing the likelihood of getting atherosclerotic plagues (Kochhar et al, 2007). Unlike the hypoglycaemic component which is more extractable in ethanol, the hypolipidemic component in C. italica is more extractable in water.…”

Section: Resultsmentioning

confidence: 99%

Anti-hyperlipidaemic and antioxidant effect of aqueous and ethanolic extracts of Cassia italica leaves in streptozotocin-induced diabetes in rats

Nadro¹

2012

J. Med. Plants Res.

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The earth is richly endowed with a variety of plants. Most of the naturally occurring plants possess medicinal properties and are thus potential sources of remedies for virtually all human ailments. The present study was designed to evaluate the hypolipidaemic and antioxidant effects of aqueous and ethanolic extracts of Cassia italica leaves in streptozotocin (STZ)-induced diabetes mellitus in rats. Lipid peroxidation as assayed by thiobarbituric acid reactive substances (TBARS) was significantly reduced (p ≤ 0.05) in STZ-induced diabetic rats on treatment with ethanolic and aqueous extracts of C. italica leaf. Oral administration of 200 mg/kg body weight of both extracts to diabetic rats for sixty-three days improved serum glucose, cholesterol, HDL-cholesterol, triglycerides levels, among other parameters. The observed anti-lipidaemic and antioxidative effect of the plant extracts against oxidative stress in diabetic rats may be attributed to the presence of flavonoids, ascorbic acid, carotenoids, tannins and phenols among the plant constituents. Flavonoids are known to be antioxidants, free radical scavengers and anti-lipoperoxidant. From the results of this study, it is evident that extracts (aqueous and ethanolic) of leaf of C. italica have anti-lipidaemic and antioxidative properties.

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Section: Resultsmentioning

confidence: 99%

Anti-hyperlipidaemic and antioxidant effect of aqueous and ethanolic extracts of Cassia italica leaves in streptozotocin-induced diabetes in rats

Nadro¹

2012

J. Med. Plants Res.

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“…HDL-C transports cholesterol from peripheral tissues to the liver, thereby reducing the amount stored in tissues and decreasing the likelihood of getting atherosclerotic plagues (Singh et al, 2007). The possible mechanism by which trace elements can exert lipid lowering activities may be explained by decreasing the cholesterol biosynthesis, particularly by decreasing the activity of hydroxyl-3-methylglutaryl-coenzyme A (HMG-CoA) reductase or by reducing the NADPH required for cholesterol synthesis and/or by stimulating glucose utilization (Kochhar et al, 2007). Tian-Jiao et al, (2011), through their immunohistochemical analysis of GLUT4 in cardiac muscle, found that trace element Se +2 restored GLUT4 expression close to normal values, suggesting that trace elements alleviated the obstacle of signal transduction on the level of postreceptor in cardiac muscle of diabetic rats.…”

Section: Ii-discussionmentioning

confidence: 99%

Biochemical Effects of Some Trace Elements in Experimental Diabetic Rats

Shawky

Abdel‐Aziz

Amer

et al. 2018

Scientific Journal of October 6 University

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The present work was done to elucidate the possible protective and antioxidant effect of chromium (Cr) as chromium chloride (CrCl2; 500 mg/k.g.), selenium (Se) as sodium selenite (Na2SeO3; 1.5 mg/k.g.) and zinc (Zn) as zinc sulphate (ZnSO4; 54 mg/k.g.) supplementation in streptozotocin induced diabetic rats. Administration of these elements daily for 60 days showed a significant decrease in MDA concentrations. The treatment resulted also in a significant increase in plasma insulin C-peptide, blood reduced glutathione (GSH) levels and superoxide dismutase (SOD)activity as well as gene expression of heart glucose transporter 4 (GLUT4) of diabetic rats. Also, the results clearly suggested that the trace elements can normalize effectively the body weight as well as high density lipoprotein (HDL-C) in streptozotocin diabetic rats. The trace elements reduced the risk of diabetic complications through rapid protective effects against lipid peroxidation by scavenging of free radicals there. These effects were more pronounced in Cr-treated group than Se and Zn-treated groups.

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“…This would definitely reduce the incidence of coronary events being the major cause of morbidity and deaths in diabetes subjects [52]. HDL-C transports cholesterol from peripheral tissues to the liver, thereby reducing the amount stores in tissue and decreasing the likelihood of getting atherosclerotic plagues [53].…”

Section: Stz [2-deoxy-2-(3-methyl-3-nitrosoureido)-d-glucopyranose]mentioning

confidence: 99%

CAMBA, a New Synthesized and Promising Protector against STZ-Induced Diabetic Complications in Rats

Hussein¹

2013

Med chem

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CAPE, one of the most active compounds in propolis, is the perfect illustration of a natural compound exhibiting diverse biological activities. However, rapid decomposition by esterase leads to its low bioavailability in vivo. The aim of the present study is to synthesis and investigates the antioxidant and protective activities of novel derivative of caffeic acid, CAMBA against STZ-induced diabetic complications in diabetic rats. Since amide is more resistant to esterase enzyme. CAMBA was synthesized by reacting the amino group of methyl anthranilate with caffeic acid in the presence of PCl 3 . Diabetic rats was induced by injection of STZ (55 mg/kg, i.p.) and diabetes was confirmed 48 h after induction, and then allowed for 7 days to stabilize blood glucose level. CAMBA (25 and 50 mg/kg b.w daily for 28 days) treated diabetic rats significantly reduced elevated blood glucose, TC, TG, atherogenic index, LDL-c, vLDL-c, hepatic, renal and cardiac TBARs and HP. The treatment also resulted in improved the insulin and insulin resistance and significantly increased serum HDL-c and GSH, SOD, CAT and GPx in the liver, kidney and heart of diabetic rats. The results clearly suggest that CAMBA treated group may effectively normalize the impaired antioxidant status in streptozotocin induced diabetes than the glibenclamide-treated groups. CAMBA exerted rapid protective effects against lipid peroxidation by scavenging of free radicals by reducing the risk of diabetic complications. Taken together, CAMBA has potential as an antioxidant agent for diabetes and deserves clinical trial in the near future as an adjuvant therapy in diabetic patients.

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Effect of Supplementation of Traditional Medicinal Plants on Serum Lipid Profile in Non-Insulin Dependent Diabetics

Cited by 8 publications

References 3 publications

Anti-hyperlipidaemic and antioxidant effect of aqueous and ethanolic extracts of Cassia italica leaves in streptozotocin-induced diabetes in rats

Anti-hyperlipidaemic and antioxidant effect of aqueous and ethanolic extracts of Cassia italica leaves in streptozotocin-induced diabetes in rats

Biochemical Effects of Some Trace Elements in Experimental Diabetic Rats

CAMBA, a New Synthesized and Promising Protector against STZ-Induced Diabetic Complications in Rats

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