Effect of supplementation with Cu and Zn on antioxidant enzyme activity in the rat tissues

Buzadžić, Biljana; Korać, Bato; Lazić, T; Obradovic, Darja

doi:10.1016/s0963-9969(01)00187-9

Cited by 26 publications

(14 citation statements)

References 11 publications

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“…Shaheen and el-Fattah [7] reported that Zn-deficient rats had a significantly decreased liver GSH content as compared to the control values. However, our results showed that GPx and GSH were unaffected by both zinc deficiency and zinc overdose, which was consistent with the findings of Buzadžić et al [32] who observed that Zn supplementation had no effect on liver GPx activity in contrast to the control group . In the present study, after subjecting the rats to a zinc deficiency the hepatic MDA and H 2 O 2 content increased, CuZn SOD as well as CAT activities were inhibited in comparison with the control group, which was mostly in agreement with the findings of other researchers [7,33] .…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, after subjecting the rats to a zinc deficiency the hepatic MDA and H 2 O 2 content increased, CuZn SOD as well as CAT activities were inhibited in comparison with the control group, which was mostly in agreement with the findings of other researchers [7,33] . However, Buzadžić et al [32] and Pathak et al [34] found that Zn supplementation had no effect on liver CAT activity. These discrepant findings might be explained by the different doses and sources of Zn treatment or, more likely, by the different physiological conditions of the animals.…”

Section: Discussionmentioning

confidence: 98%

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Effects of Zinc on Hepatic Antioxidant Systems and the mRNA Expression Levels Assayed by cDNA Microarrays in Rats

Jing¹,

Sun²,

Zi³

et al. 2007

Ann Nutr Metab

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Background: This study evaluated effects of zinc on the hepatic lipid peroxidation, antioxidant components and mRNA expression levels in rats. Methods: Three diets with different Zn levels including Zn adequacy (ZA; 34.50 mg/kg, control), Zn deficiency (ZD; 3.30 mg/kg), and Zn overdose (ZO; 345.45 mg/kg) were fed to rats for 6 weeks. The mRNA expression levels were analyzed by cDNA microarrays. Results: The body weight of rats fed the ZD diet was less (p < 0.01) than that of rats fed the ZA diet. Zn overdose elevated body weight, but the increase was not detected (p > 0.05) at week 6. Although copper and iron status in serum were declined (p < 0.01), those in liver were not affected (p > 0.05) by the high intake of zinc. The glutathione peroxidase (GPx) and glutathione (GSH) remained unchanged (p > 0.05) by zinc treatment. Rats fed the ZD diet showed reductions(p < 0.01) in the Cu-Zn superoxide dismutase (Cu-Zn SOD) and catalase (CAT) activity, and increases (p < 0.01) in the malondialdehyde and hydrogen peroxide (H₂O₂) contents. Rats fed the ZO diet particularly had higher Cu-Zn SOD (p < 0.01) activity. The mRNA expression levels of SOD were upregulated in the ZO group, and CAT was downregulated in the ZD group, while no changes in GPx mRNA levels were found after zinc treatment. Conclusion: The study suggested that zinc deficiency largely decreased body weight; zinc overdose, however, moderately stimulated growth in the early growing phase of rats. High dietary zinc did not compete with liver copper and iron status. Although Zn deficiency impaired antioxidant functions, zinc overdose hardly enhanced the antioxidant systems of animals.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Effects of Zinc on Hepatic Antioxidant Systems and the mRNA Expression Levels Assayed by cDNA Microarrays in Rats

Jing¹,

Sun²,

Zi³

et al. 2007

Ann Nutr Metab

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“…Thus, the consumption of A. crassiflora pulp or ACF can also bring beneficial effects to human health due to its magnesium content. A. crassiflora studied by Almeida, Agostini-Costa and Silva (2008) In this way, the consumption of copper and zinc is essential to maintain enzymatic activities in the body (BUZADŽIĆ et al, 2002). Oat in the USA contains amounts of zinc close to that found in ACF, but the values of copper is the opposite (PADOVANI et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Nutritional composition of Annona crassiflora pulp and acceptability of bakery products prepared with its flour

2013

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“…Buzadžić et al (2002) reported that best bioavailability of zinc is ensured by administering zinc chelate together with peptides and amino acids. Bioavailability of zinc methionine chelate is higher by 206% compared to supplementation with zinc sulphate (Wedekind et al 1992).…”

Section: Discussionmentioning

confidence: 99%

Effect of inorganic and organic zinc supplementation on coccidial infections in goat kids

et al. 2011

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The aim of this study was to identify the effect of zinc-enriched diet fed to goats and their kids on the number of Coccidia oocysts shed by kids, on clinical signs of coccidiosis, weight gains, and kids' blood plasma concentration of zinc. A total of 22 goat kids were divided into 4 groups of 5 or 6 animals. Goats and kids from the control group did not receive any additional zinc, the second group was supplemented with inorganic zinc (zinc oxide), the third group was given zinc lactate, and the fourth group received chelated zinc. Samples of kids' faeces were taken weekly from 3 to 9 weeks of their age (a total of 7 samples were taken). Samples of faeces were examined by a quantitative method to detect the number of oocysts. Kids were weighed weekly and their blood was taken in order to determine zinc concentrations in blood plasma. Animals from the group supplemented with zinc chelate and zinc lactate shed a significantly (p ≤ 0.05) lower number of oocysts (13.4% and 11.9%, respectively) compared to the number of oocyst shed by control and zinc oxide supplemented groups (25% and 49.7%, respectively). Shedding of oocysts was not accompanied by clinical symptoms of coccidiosis in any of the groups. Kids supplemented with zinc chelate showed significantly highest weight gains and blood plasma concentration of zinc (p ≤ 0.05) as compared to control and inorganic zinc supplemented groups. Organic zinc is to be recommended to be used as a prophylaxis against coccidiosis in goat kids. Eimeria, coccidiosis, weight gain, zinc chelate, zinc lactate, zinc oxideInfections caused by Eimeria coccidia belong to the most significant protozoal infections. In goat kids, six specific Eimeria species were detected, namely E. arloingi, E. ninakohlyakimovae, E. christenseni, E. hirci, E. caprina and E. alievi. Their prevalence is considered to be global. In Spain, coccidiosis affects 96.1% goat kids fed milk (Ruiz et al. 2006). In northern Jordan, coccidiosis occurs in 85% local goats and 54% of them show concurrent infection with multiple Eimeria species. Incidence of concurrent infection was significantly higher in kids (66%) than in animals over 1 year of age (49%) (Mahmoud and Hossan 2003). Prevalence of coccidia in the U.S.A. was 100% (n = 318); in Australia, coccidia were detected in 97% kids out of 497 (Reeg et al. 2005). In the Czech Republic, Strnadová et al. (2008) found coccidia in 54% kids less than 4 months old.The course of clinical coccidiosis in goat kids can be acute, subacute, chronic or latent. The first symptoms of acute coccidiosis include raised temperature, watery diarrhea containing blood and particles of intestinal mucosa, mucosal anaemia, conjunctivitis and rhinitis. Mahmoud and Hossan (2003) reported up to 58% mortality of kids. Animals from 1 to 3 months of age are most susceptible and they shed oocysts most intensively between 5 and 8 weeks of age (Reeg et al. 2005). The course of infection is affected by the number of oocysts being shed. Coccidiosis is considered to be clinical when more tha...

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Effect of supplementation with Cu and Zn on antioxidant enzyme activity in the rat tissues

Cited by 26 publications

References 11 publications

Effects of Zinc on Hepatic Antioxidant Systems and the mRNA Expression Levels Assayed by cDNA Microarrays in Rats

Effects of Zinc on Hepatic Antioxidant Systems and the mRNA Expression Levels Assayed by cDNA Microarrays in Rats

Nutritional composition of Annona crassiflora pulp and acceptability of bakery products prepared with its flour

Effect of inorganic and organic zinc supplementation on coccidial infections in goat kids

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