2020
DOI: 10.1186/s13098-020-00580-w
|View full text |Cite
|
Sign up to set email alerts
|

Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial

Abstract: Background Patients with type 2 diabetes mellitus (T2DM) are characterized by chronic hyperglycemia as a consequence of decreased insulin sensitivity, which contributes to bone demineralization and could also be related to changes in serum levels of osteocalcin and insulin, particularly when coupled with a deficiency in the daily consumption of vitamins D3 and K2. The objective of this study was to evaluate the effect of vitamin D3 and vitamin K2 supplements alone or in combination on osteocalcin levels and me… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
10
0
1

Year Published

2021
2021
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 16 publications
(11 citation statements)
references
References 42 publications
0
10
0
1
Order By: Relevance
“…In the VK2 group, again a significant decrease in glycemia (p = 0.002), percentage of pancreatic β-cells (p = 0.002), and HOMA-IR (p = 0.041), and a statistically significant increase of cOC concentrations were observed. The increase in the cOC concentration could be explained by the action VK2 as a cofactor of carboxylases during activation of OC [141].…”
Section: The Effects Of Vitamin K On Metabolic Disordersmentioning
confidence: 99%
“…In the VK2 group, again a significant decrease in glycemia (p = 0.002), percentage of pancreatic β-cells (p = 0.002), and HOMA-IR (p = 0.041), and a statistically significant increase of cOC concentrations were observed. The increase in the cOC concentration could be explained by the action VK2 as a cofactor of carboxylases during activation of OC [141].…”
Section: The Effects Of Vitamin K On Metabolic Disordersmentioning
confidence: 99%
“…Recent clinical trials display T2DM risk reduction was happened with vitamin K supplementation, in addition vitamin K 2 improvs insulin sensitivity through the involvement of vitamin K-dependent-protein osteocalcin metabolism and that favors β-cell proliferation, insulin secretion and sensitivity. Vitamin K 2 shows better effect than vitamin K 1 in the context of T2DM [76].…”
Section: Brief Discussion Of Vitamin K Biologymentioning
confidence: 90%
“…Type II diabetes is a risk factor for and a comorbidity in AD. Three different RCTs found that supplementation with VK2 reduced glycemia and insulin resistance in patients with type II diabetes [ 145 , 146 , 147 ]. VK2 intake has been shown to be inversely associated with the risk of type II diabetes [ 148 ].…”
Section: Vitamin K2 and Alzheimer’s Diseasementioning
confidence: 99%