Determining the elastic constants of anisotropic films deposited on anisotropic substrates from V(z) measurements obtained by using a line-focus acoustic microscope is discussed in Chapter 5. The procedure has three essential components: (1) measuring the V( z) curve as a function of direction of wave mode propagation in the thin-film/substrate system at fixed frequency and/or as a function of the frequency or film thickness for a fixed direction, (2) developing a theoretical measurement model for parametric studies of V(z) curves, and (3) obtaining elastic constants by systematically comparing wave-mode velocities obtained from the theoretical model and V(z) measurements. Examples primarily concern transition metal nitride films and superlattice films used as hard protective coatings for softer surfaces. Results are presented for several thin-film/substrate configurations. Advantages of the method as well as remaining problems that require further investigation are discussed.