First and foremost, I would like to express my deepest gratitude to my supervisor, Dr. Sing Yang Chiam, for the continuous support of my research with his immense knowledge and expertise, for his enthusiasm, patience, and for granting me much freedom to carry out independent work. I learned what a true researcher should be from him. I would like to express my sincere gratitude to Dr. Jisheng Pan, my co-supervisor, who patiently guided me throughout important experiments and helped in the scientific discussions. My utmost respect and gratitude go to my NTU supervisor, professor Sum Tze-Chien, who supported me in every step and guided me with his wise advice throughout this journey. I would like to thank Dr. Yi Ren and Dr. Jayce JW Cheng for their assistance and instructions, which made my Ph.D. enjoyable. My sincerest thanks also go to Agency for Science, Technology and Research (A*STAR) for generously providing me with the Singapore International Graduate Award (SINGA) scholarship to pursue my Ph.D. studies.Last but most importantly, my heartfelt gratitude goes to my wife (Zahra) and my family, who are a great source of motivation and inspiration each and every day for me. For their unconditional love, support, and understanding throughout my life.