Effect of surface topography and chemistry on adhesion, orientation and growth of fibroblasts on nickel–titanium substrates

Ponsonnet, Laurence; Comte, V.; Othmane, Ali; Lagneau, C.; Charbonnier, M.; Lissac, M.; Jaffrezic, N.

doi:10.1016/s0928-4931(02)00097-8

Cited by 140 publications

(93 citation statements)

References 28 publications

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“…roughness) on material surfaces are also crucial in cell and tissue responses to biomaterials. Indeed, surface roughness has shown to alter fibroblast proliferation on aluminiun, titanium and titanium alloys substrates [60][61][62] , and strongly influence bacterial attachment to nitinol, titanium and glass surfaces [63][64][65][66] . Overall, the three functionalization strategies displayed the same value of R a (~ 30 nm; Table 2), slightly increasing the original R a of control samples (~ 25 nm; Table 2).…”

Section: Physicochemical Characterization Of the Surfacesmentioning

confidence: 99%

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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Dental implant failure can be associated to infections which develop into periimplantitis. In order to reduce biofilm formation, several strategies focusing on the use of antimicrobial peptides (AMP) have been studied. To covalently immobilize these molecules onto metallic substrates several techniques have been developed, including silanization and polymer brush prepared by surface-initiated atom transfer radical polymerization (ATRP), with varied peptide binding yield and antibacterial performance. The aim of the present study was to compare the efficiency of these methods to immobilize the lactoferrin-derived hLf1-11 antibacterial peptide onto titanium, and evaluate their antibacterial activity in vitro.Smooth titanium samples were coated with hLf1-11 peptide under three different conditions: silanization with APTES, and polymer brush based coatings with two different silanes. Peptide presence was determined by X-ray photoelectron spectroscopy and the mechanical stability of the coatings was studied under ultrasonication. The LDH assays confirmed that HFFs viability and proliferation were no affected by the treatments. The in vitro antibacterial properties of the modified surfaces were tested with two oral strains (Streptococcus sanguinis and Lactobacillus salivarius) showing an outstanding reduction. A higher decrease in bacterial attachment was noticed when samples were modified by ATRP methods compared to silanization. This effect is likely due to the capacity to immobilize more peptide on the surfaces using polymer brushes and the non-fouling nature of polymer PDMA segment.3

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Section: Physicochemical Characterization Of the Surfacesmentioning

confidence: 99%

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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“…Ponsonnet et al 39 attributed the higher atomic ratio (0.25) of grade 2400 polished Nitinol to Ni diffusion to the surface during mechanical polishing. Nevertheless, it should be noted that the thicknesses of the oxide layers given in the literature for mechanically polished Nitinol vary in a wide range from 52 nm 40 to 5 nm.…”

Section: Discussionmentioning

confidence: 99%

Effect of Nitinol surface treatments on its physico‐chemical properties

et al. 2009

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The main purpose of this work is the study of different physicochemical treatments on Nitinol slabs and wires, with the aim of inducing the formation of a TiO(2) surface film capable of increasing the corrosion resistance of the material and of reducing the release of Ni when the Nitinol samples were immersed in simulated body fluid (SBF). To this end, a battery of measurements (surface roughness, contact angle, electrochemical corrosion, chemical analysis as a function of depth, and Ni release to SBF) has been used to characterize Nitinol commercial samples, as received, and also after the different treatments performed. The results clearly indicate the effectiveness of the passivation TiO(2) layer as a barrier against Ni leaching, and the detrimental effects of any processes (such as polishing or cutting) that result in exposure of areas not coated by the TiO(2) film. Chemical methods such as oxidation in nitric acid or hydrothermal treatment of the samples (by prolonged immersion in boiling water) seem to provide simple and efficient ways of forming TiO(2) films of adequate thickness on the Nitinol surface.

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“…To summarize some of the major concerns related to the use of Nitinol one could cite aspects that seems to be related to the presence of Ni in the alloy composition and its influence beyond the TiO 2 barrier or its reliability as implant material due to: leaching of Ni iones [3,4], failure under cyclic deformations compared to other biomedical materials (Nitinol cracks at low stress intensity, and cracks propagate quickly [5][6][7][8][9][10][11], while clinical observational studies have shown a surprisingly high percentage of fracture in a variety of Nitinol devices [12][13][14][15][16][17][18], allergenic reactions in Ni hypersensitive patients [19][20][21][22], unfavorable healing processes (osteogenesis) compared to Stainless steels and Ti-based alloys [23], higher cell death rates [24], proliferation of human gingival fibroblasts on NiTi samples with rough surface is slow compared to stainless steels and Ti alloys with the same surface roughness [25].…”

Section: Introductionmentioning

confidence: 99%

Development of Ti-Nb-Zr shape memory alloys

Chilnicean

Sprâncenatu

Zhao

et al. 2017

AIP Conference Proceedings

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Abstract. The molecular orbital method was used to identify Ni-free shape memory alloys in the Ti-Nb-Zr system. The alloys were manufactured via the arc melting technique, in Ar atmosphere and subsequently solution annealed with quenching in water. The corresponding microstructure was analyzed by X-ray diffraction and scanning electron microscopy to show the formation of martensite. A chart detailing the sequence of transformation was drawn based on calorimetric measurements and structural analysis.

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Effect of surface topography and chemistry on adhesion, orientation and growth of fibroblasts on nickel–titanium substrates

Cited by 140 publications

References 28 publications

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

Effect of Nitinol surface treatments on its physico‐chemical properties

Development of Ti-Nb-Zr shape memory alloys

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