Effect of surface treatment on surface roughness and Ni content of nitinol stents

Tak, Yongsug; Lee, Byoung Gu; Kim, Jaemin; Kim, Jang Yong

doi:10.1504/ijsurfse.2016.077541

Cited by 2 publications

(1 citation statement)

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“…31 Currently used bone implants in orthopeadic surgery comprise pure Ti and more often Ti alloys with Al, V, Zr, etc., since these alloys are less expensive and able to provide superior biocompatibility and mechanical characteristics in comparison to pure Ti. 32,33 The production of Ti implants is based on conventional metal and metallurgical processing techniques with limitations such as production with fixed shapes and dimensions, and therefore, they lack customization for specific cases such as children or due cancer, where local drug delivery of anticancer is required. In such cases, expensive and time-consuming implant alterations are made by postprocessing which are not acceptable where urgent interventions are required.…”

Section: Introductionmentioning

confidence: 99%

Engineering of Micro- to Nanostructured 3D-Printed Drug-Releasing Titanium Implants for Enhanced Osseointegration and Localized Delivery of Anticancer Drugs

Maher

Kaur²,

Lima-Marques³

et al. 2017

ACS Appl. Mater. Interfaces

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Primary and secondary bone cancers are major causes of pathological bone fractures which are usually treated through implant fixation and chemotherapy. However, both approaches face many limitations. On one hand, implants may suffer from poor osseointegration, and their rejection results in repeated surgery, patient's suffering, and extensive expenses. On the other hand, there are severe systemic adverse effects of toxic chemotherapeutics which are administrated systemically. In this paper, in order to address these two problems, we present a new type of localized drug-releasing titanium implants with enhanced implants' biointegration and drug release capabilities that could provide a high concentration of anticancer drugs locally to treat bone cancers. The implants are fabricated by 3D printing of Ti alloy followed by an anodization process featuring unique micro- (particles) and nanosurface (tubular arrays) topography. We successfully demonstrate their enhanced bone osseointegration and drug loading capabilities using two types of anticancer drugs, doxorubicin (DOX) and apoptosis-inducing ligand (Apo2L/TRAIL). In vitro study showed strong anticancer efficacy against cancer cells (MDA-MB-231-TXSA), confirming that these drug-releasing implants can be used for localized chemotherapy for treatment of primary and secondary bone cancers together with fracture support.

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Section: Introductionmentioning

confidence: 99%