Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles

Bhattacharyya, Sayani; Reddy, P. Ranga

doi:10.4274/tjps.galenos.2018.82160

Cited by 28 publications

(12 citation statements)

References 15 publications

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“…So finasteride-loaded stearic acid SLNs are having more capacity of drug loading which makes them safer for use. Similar types of results were also discussed in the previous study where the SLNs of stearic acid showed drug entrapment of 68.38% [ 41 ].…”

Section: Resultssupporting

confidence: 88%

Physicochemical Characterization of Chitosan-Decorated Finasteride Solid Lipid Nanoparticles for Skin Drug Delivery

Sohaib

Shah

et al. 2022

BioMed Research International

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Finasteride is considered the drug of choice for androgenic alopecia and benign prostate hyperplasia. The aim of the study was to formulate nanodrug carriers of finasteride with enhanced retentive properties in the skin. The finasteride was formulated as solid lipid nanoparticles that were decorated with different concentrations of chitosan for improved retentive properties. Solid lipid nanoparticles (SLNs) were synthesized by “high-speed homogenization technique” using stearic acid as a solid lipid while PEG-6000 and Tween-80 were used as surfactants. The SLNs were evaluated for particle size, polydispersity index (PDI), zeta potential, drug entrapment efficiency, and drug release behavior. The mean particle size of SLNs was in the range of 10.10 nm to 144.2 nm. The PDI ranged from 0.244 to 0.412 while zeta potential was in the range of 8.9 mV to 62.6 mV. The drug entrapment efficiency in chitosan undecorated formulations was 48.3% while an increase in drug entrapment was observed in chitosan-decorated formulations (51.1% to 62%). The in vitro drug release studies of SLNs showed an extended drug release for 24 hours after 4 hours of initial burst release. The extended drug release was observed in chitosan-coated SLNs in comparison with uncoated nanoparticles. The permeation and retention study revealed higher retention of drug in the skin and low permeation with chitosan-decorated SLNs that ranged from 39.4 μg/cm2 to 13.2 μg/cm2. TEM images depicted spherical shape of SLNs. The stability study confirmed stable formulations in temperature range of 5°C and 40°C for three months. It is concluded from this study that the SLNs of finasteride were successfully formulated and chitosan decoration enhanced the drug retention in the skin layers. Therefore, these formulations could be used in androgenic alopecia and benign prostate hyperplasia to avoid the side effects, drug degradation, and prolonged use of drug with conventional oral therapy.

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Section: Resultssupporting

confidence: 88%

Physicochemical Characterization of Chitosan-Decorated Finasteride Solid Lipid Nanoparticles for Skin Drug Delivery

Sohaib

Shah

et al. 2022

BioMed Research International

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“…After an appropriate dilution, absorbance was determined by UV -Spectrophotometer ((Model Shimadzu 1800, Japan)) at 288 using HSPC solution as blank, and the drug content was calculated using a calibration curve. 18 The drug loading was calculated using equation (3).…”

Section: Determination Of Drug Content and Drug Loading In Spcmentioning

confidence: 99%

Development and Characterization of Silymarin Phospholipid Complex for Improved Solubility, and Toxicological Evaluation in Experimental Animals

Singh

Patil

2022

IJPI

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Objectives:The silymarin phytosome (SPY) was developed to improve the solubility and dissolution. The prepared phytosome was evaluated for hemolytic, membrane stabilization activity, and in vivo acute and subchronic toxicity. Materials and Methods: The toxicological evaluation was carried out by assessing its effects on liver, kidney, brain, lungs, heart and spleen in a rat model. In addition to confirmation of formation of phytosome, the physical-chemical characterization was done by FTIR, DSC, PXRD, and 1H NMR. Results: The optimized formulation has higher aqueous solubility of SPY compared to that of pure silymarin. The formulation also exhibited a significantly higher rate and extent of silymarin release in dissolution studies. The percent hemolysis for SPY was significantly less than silymarin. As a result, SPY can be concluded to be non-toxic and biocompatible for in vivo administration. SPY significantly inhibited hypotonic solutioninduced hemolysis in a dose-dependent manner. In acute oral toxicity, no treatment-related death or toxic signs were observed. The sub-acute test observations indicated that there are no treatment-related changes up to the high dose level. Food consumption, body weight, organ weight, hematological parameters, biochemical parameters and histopathological examination revealed no abnormalities. Conclusion: The study shows that SPY is a promising and viable strategy for improving the delivery of silymarin.

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“…The amounts of PVA, polysorbate 80, and PEG-400 are based on previous studies where surfactant and cosurfactant form emulsion. The amount of stearic acid was also based on a previous study with the best formula using 1 g. The planned variation point was the amount of stearic acid from 1 to 2 g (Bhattacharyya and Reddy, 2019;Mardiyanto et al, 2021;Rupenagunta et al, 2011;Sarathchandiran, 2012). The composition of the ingredients for the formulation of lipid nanoparticles can be seen in Table 1.…”

Section: Lipid Nanoparticle Formulationmentioning

confidence: 99%

Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods

Mardiyanto

Untari

Mara

et al. 2022

Sci. Technol. Indones

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The pandemic period has caused antibiotics highly recommended to cure infections. The use of macrolide antibiotics has greatly increased recently due to outbreaks of diseases that attack the human respiratory tract all of part of the world. One member of the macrolide group is erythromycin ethyl succinate which has low solubility in water. Therefore, this study aims to convert erythromycin ethyl succinate into lipid nanoparticles in an attempt to increase solubility. The method for the formation of nanoparticles is heating emulsification and homogenization. The results obtained in the form of formula 1 (F1) showed the percent encapsulation of 85.688±0.30641. The physical properties were that it has a size of 398.9±1.4 nm, a PDI of 0.3895±0.0015, and zeta potential of -17.45±0.15 mV respectively. The stability was determined by an accelerated test by the influence of extreme temperature and mechanics affecting the stability of the particles as an indication of decreasing the pH and particle precipitation. The solubility of erythromycin ethyl succinate in the form of lipid nanoparticles was increased in a comparison with the pure substance of erythromycin ethyl succinate.

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Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles

Cited by 28 publications

References 15 publications

Physicochemical Characterization of Chitosan-Decorated Finasteride Solid Lipid Nanoparticles for Skin Drug Delivery

Physicochemical Characterization of Chitosan-Decorated Finasteride Solid Lipid Nanoparticles for Skin Drug Delivery

Development and Characterization of Silymarin Phospholipid Complex for Improved Solubility, and Toxicological Evaluation in Experimental Animals

Formulation and Evaluation of Solid Lipid Nanoparticles Loading Erythromycin Ethylsuccinate by Heating Emulsification and Homogenization Methods

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