Effect of surfactants on human stratum corneum: electron paramagnetic resonance study

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

“…6) In addition, assessments to understand the mechanism of action of CPEs are carried out by differential scanning calorimetry (DSC), Fourier transform (FT)-IR, ESR, or X-ray diffractometry (XRD). [7][8][9][10] Although these techniques can observe changes in the SC structure, they require specialist manipulation techniques and are labor intensive, time consuming, and costly. High-throughput screening (HTS) techniques have been introduced using electrical resistance-based methods.…”

Kinetic Measurements Using EPR Imaging with a Modulated Field Gradient

“…The horny layer was changed in a chemical and a physical way. The chemical treatment of the horny layer was performed with the known penetration enhancer DMSO (Dimethylsulfoxide) (28,29). The physical influence on the horny layer was characterized by removing this layer with tape stripping which is also a known method for removing the horny layer from the skin.…”

Interaction of Antidepressant Drug, Clomipramine, with Model and Biological Stratum Corneum Membrane as Studied by Electron Paramagnetic Resonance

“…Because SC serves as the barrier of the skin, it has been studied extensively using different techniques. In recent studies, hydration of SC and its effects on phase transition, mobility, and transport of molecules were investigated using sorption microcalorimetry, ATR‐FTIR, termomicroscopy, DSC, wide‐line 1 H NMR, 13 C solid‐state NMR, and EPR . It was found that the ratio between fluid and rigid lipids increases upon the hydration, what could be a reason for the enhanced permeability of intact SC upon hydration …”