Effect of Surfactants on the Melt Viscosity and Extent of Drug Embedment of Paraffin Wax Blends in Spray Congealing

Ouyang, Hongyi; Poh, Annabel Shi Yin; Heng, Paul Wan Sia; Chan, Lai Wah

doi:10.1007/s12247-020-09517-2

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…In addition, the congealing step might affect the solid-state properties and thus the biopharmaceutical characteristics of the APIs. The lower the temperature of the collecting chamber, the higher is the cooling rate influencing the crystallization of both the APIs and the excipients [23].…”

Section: Spray Congealing: Equipment and Process Parametersmentioning

confidence: 99%

“…suspended as solid powder or partially/totally solubilized) of the drug and the presence of additives. Specifically, powder substances that are dispersed in the molten mixture tend to significantly increase the viscosity of the sprayed mixture [23]. Both viscosity and surface tension vary with temperature, therefore the temperature of the molten carrier is also of fundamental importance [24].…”

Section: Spray Congealing: Equipment and Process Parametersmentioning

confidence: 99%

See 1 more Smart Citation

Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

Bertoni

Hasa

Albertini

et al. 2022

Drug Deliv. and Transl. Res.

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Section: Spray Congealing: Equipment and Process Parametersmentioning

confidence: 99%

Section: Spray Congealing: Equipment and Process Parametersmentioning

confidence: 99%

Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

Bertoni

Hasa

Albertini

et al. 2022

Drug Deliv. and Transl. Res.

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show abstract

Sustainable and cleaner approach for paraffin wax treatment via CO2-induced polarity transformation of switchable solvents

et al. 2023

Journal of Cleaner Production

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Tailoring Fumaric Acid Delivery: The Role of Surfactant-Enhanced Solid Lipid Microparticles via Spray-Congealing

Tsai,

Chen,

Chen

et al. 2024

Foods

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Fumaric acid, a naturally occurring preservative with antimicrobial properties, has been widely used in the baking industry. However, its direct addition interferes with yeast activity and negatively impacts the gluten structure. This study investigates the potential of spray-congealing as a method for encapsulating fumaric acid within solid lipid microparticles. The selection of lipid carriers and surfactants is critical, so hydrogenated palm stearin, hydrogenated rapeseed oil, and Compritol ATO 888 (glyceryl behenate) were chosen as lipid carriers, and propylene glycol monostearate and glyceryl monolaurate were utilised as surfactants with varying concentrations. Rheological properties, encapsulation efficiency, particle size, moisture content, and thermal behaviour were assessed, along with the release profiles under different temperature conditions simulating the baking process. The findings indicate that the addition of surfactants significantly impacts the viscosity and stability of the molten mixtures, which in turn affects the spray-congealing process and the release of fumaric acid. The temperature-dependent and time-dependent release profiles demonstrate the potential for customising release kinetics to suit specific applications, such as the baking industry. This study may contribute to the development of a controlled-release system that synchronises with the baking process, thereby optimising fumaric acid’s functionality while preserving the quality of baked goods.

show abstract

Effect of Surfactants on the Melt Viscosity and Extent of Drug Embedment of Paraffin Wax Blends in Spray Congealing

Cited by 3 publications

References 52 publications

Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

Better and greener: sustainable pharmaceutical manufacturing technologies for highly bioavailable solid dosage forms

Sustainable and cleaner approach for paraffin wax treatment via CO2-induced polarity transformation of switchable solvents

Tailoring Fumaric Acid Delivery: The Role of Surfactant-Enhanced Solid Lipid Microparticles via Spray-Congealing

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