Effect of surgery-induced acute muscle wasting on postoperative outcomes and quality of life

Huang, Dongdong; Ji, Yin; Zhou, Donglei; Li, Bo; Wang, Su‐Lin; Chen, Xiaolei; Yu, Zhen; Zhuang, Cheng‐Le

doi:10.1016/j.jss.2017.05.045

Cited by 41 publications

(62 citation statements)

References 33 publications

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“…14,15 Additionally, muscle wasting can occur rapidly and irreversibly in some conditions. For instance, gastric cancer patients exhibit muscle wasting of~10% within 7 days after surgery, 16 similar to the values observed after 5 days of bed rest in elderly. 17 Thus, strategies able to reduce muscle wasting and/or increase muscle mass are needed.…”

supporting

confidence: 76%

Exercise with blood flow restriction: an effective alternative for the non‐pharmaceutical treatment for muscle wasting

Conceição

Ugrinowitsch

2019

J cachexia sarcopenia muscle

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Significant muscle wasting is generally experienced by ill and bed rest patients and older people. Muscle wasting leads to significant decrements in muscle strength, cardiorespiratory, and functional capacity, which increase mortality rates. As a consequence, different interventions have been tested to minimize muscle wasting. In this regard, blood flow restriction (BFR) has been used as a novel therapeutic approach to mitigate the burden associated with muscle waste conditions. Evidence has shown that BFR per se can counteract muscle wasting during immobilization or bed rest. Moreover, BFR has also been applied while performing low intensity resistance and endurance exercises and produced increases in muscle strength and mass. Endurance training with BFR has also been proved to increase cardiorespiratory fitness. Thus, frail patients can benefit from exercising with BFR due to the lower cardiovascular and join stress compared with traditional high intensity exercises. Therefore, low intensity resistance and endurance training combined with BFR may be considered as a novel and attractive intervention to counteract muscle wasting and to decrease the burden associated with this condition.

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supporting

confidence: 76%

Exercise with blood flow restriction: an effective alternative for the non‐pharmaceutical treatment for muscle wasting

Conceição

Ugrinowitsch

2019

J cachexia sarcopenia muscle

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“…The definition of clinically relevant SRML is therefore based on combining data from three previous published studies that examined acute muscle loss in surgical patients. [10][11][12] In most previous clinical studies, changes in skeletal muscle mass were investigated by CT scans at different time points. 3,4,11,12 In the meantime, muscle ultrasound has emerged as a common, inexpensive, reliable, and valid imaging technique for measuring skeletal muscle at the bedside in patients with different clinical conditions, without exposing patients to harmful ionizing radiation.…”

Section: Discussionmentioning

confidence: 99%

“…10 In another study, one out of three cancer patients developed clinically relevant surgery-related muscle loss (SRML) within one week after curative gastric cancer surgery. 11 Clinically relevant SRML was associated with postoperative complications and a longer length of hospital stay. These findings were also confirmed in a study including 254 patients who underwent major hepatectomies with extrahepatic bile duct resections.…”

Section: Introductionmentioning

confidence: 96%

“…[5][6][7][8][9] In contrast to the growing amount of knowledge about the impact of muscle loss in ICU patients, there have been only a few studies reporting the amount of muscle loss in patients after major surgery. [10][11][12][13] In patients who underwent elective high-risk cardiothoracic surgery, 55% developed quadriceps atrophy seven days after surgery. 10 In another study, one out of three cancer patients developed clinically relevant surgery-related muscle loss (SRML) within one week after curative gastric cancer surgery.…”

Section: Introductionmentioning

confidence: 99%

“…Only one study investigated and identified two independent predictors for clinically relevant SRML (age ≥65 years and preoperative diabetes). 11 These few studies demonstrate that clinically relevant SRML might be a major problem for our current healthcare system based on its impact on several short-term postoperative problems and its postoperative impact on QoL and fatigue.…”

Section: Introductionmentioning

confidence: 99%

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Impact and risk factors for clinically relevant surgery-related muscle loss in patients after major abdominal cancer surgery: study protocol for a prospective observational cohort study (MUSCLE POWER)

et al. 2019

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Background: Surgery-related muscle loss (SRML) occurs in at least one out of three cancer patients within one week after major surgery. Though, this important phenomenon has hardly been investigated. Methods: The MUSCLE POWER is a prospective, observational cohort study that investigates the presence, impact, and predictors for clinically relevant SRML in 178 cancer patients after major abdominal surgery using ultrasound measurements, squeeze and force measurements, and QoL questionnaires. Primary endpoint is the proportion of patients with clinically relevant SRML defined as ≥5% muscle loss within one week after surgery, measured by the cross-sectional area (CSA) of three different muscles: m. biceps brachii, m. rectus femoris, and m. vastus intermedius. Possible correlation with QoL and fatigue up to six months after surgery will be investigated. Daily physical activity during hospital stay will be monitored by a motility tracker, and protein intake will be monitored by a dietician. Possible predictors for clinically relevant SRML-consisting of age ≥65 years, preoperative diabetes, preoperative sarcopenia, major postoperative complications (Clavien-Dindo ≥III), insufficient physical activity, and insufficient postoperative protein intake-will be investigated with a multivariable logistic regression analyses with a backward stepwise approach. Variables with a p<0.05 will be retrained in the final multivariable model. Discussion: The MUSCLE POWER investigates the presence and impact of clinically relevant SRML in cancer patients after major abdominal surgery. Crucial information regarding possible predictors for clinically relevant SRML can be used in future intervention studies to prevent postoperative muscle loss and subsequently improve postoperative outcome and QoL.

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Comparison of surgical outcomes and postoperative nutritional parameters between subtotal and proximal gastrectomy in patients with proximal early gastric cancer

Soneda,

Terashima,

Koseki

et al. 2024

Annals of Gastroent Surgery

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AimIn this study, we evaluated the difference in short‐term outcomes and postoperative nutritional status between subtotal gastrectomy (sTG) and proximal gastrectomy (PG) to determine the optimal surgical treatment for early gastric cancer in the upper third of the stomach.MethodsPatients who underwent laparoscopic or robotic sTG or PG at the Shizuoka Cancer Center in Shizuoka between January 2014 and December 2020 were enrolled in this retrospective study. Patient characteristics, surgical outcomes, endoscopic findings, and postoperative nutritional changes, including blood tests, body weight, psoas muscle, and subcutaneous and visceral adipose tissue, were measured and compared between the two groups.ResultsA total of 110 patients were enrolled, including 42 in the sTG group and 68 in the PG group. Albumin and hemoglobin levels were comparable between the two groups. Changes in body weight and psoas mass index measured over 36 months postoperatively were favorable in the sTG group compared with the PG group (p = 0.005 and p = 0.002, respectively). There were no significant differences in subcutaneous or visceral adipose tissue between the two groups (p = 0.331 and 0.845, respectively).ConclusionsTG is the preferred function‐preserving gastrectomy procedure for early gastric cancer in the upper third of the stomach because it is associated with less postoperative body weight loss and psoas mass index loss.

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Effect of surgery-induced acute muscle wasting on postoperative outcomes and quality of life

Cited by 41 publications

References 33 publications

Exercise with blood flow restriction: an effective alternative for the non‐pharmaceutical treatment for muscle wasting

Exercise with blood flow restriction: an effective alternative for the non‐pharmaceutical treatment for muscle wasting

Impact and risk factors for clinically relevant surgery-related muscle loss in patients after major abdominal cancer surgery: study protocol for a prospective observational cohort study (MUSCLE POWER)

Comparison of surgical outcomes and postoperative nutritional parameters between subtotal and proximal gastrectomy in patients with proximal early gastric cancer

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