Effect of surgery on albumin synthesis rate in humans

Ankar, B. A.C. van; Hulsewé, Karel W. E.; Wagenmakers, Anton J. M.; Deutz, N.E.P.; Meyenfeldt, M.F. von; Soeters, P.B.

doi:10.1097/00042737-199812000-00215

Cited by 4 publications

(4 citation statements)

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“…However, in the present study, despite evidence of an ongoing acute-phase response, albumin synthesis rates were not reduced in either the fasting or fed state. These findings are in keeping with other studies showing that, in the fasting state, albumin synthesis is not reduced in cancer (19) after surgery (5,42), after vaccination (12), or after stress hormone infusion (28). Moreover, in the fed state, it has been shown that albumin synthesis rates are, in fact, higher than in control subjects after acute head injury (25).…”

Section: Discussionsupporting

confidence: 91%

Liver export protein synthetic rates are increased by oral meal feeding in weight-losing cancer patients

Barber

Fearon

McMillan

et al. 2000

American Journal of Physiology-Endocrinology and Metabolism

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We have demonstrated previously that, in the fasting state, whereas albumin synthesis is similar in cachectic cancer patients compared with controls, fibrinogen synthesis is increased. Whether synthesis of these proteins is altered after an oral meal was examined in eight weight-losing pancreatic cancer patients and six healthy controls by use of an intravenous flooding dose of [(2)H(5)]- or [(2)H(8)]phenylalanine. Cancer patients had a median weight loss of 19%, a significantly lower serum albumin concentration, and a significantly higher plasma fibrinogen concentration than controls (P < 0.005). Fasting albumin synthesis rates were similar between cancer patients and controls (median total synthesis rate 11.3 vs. 13.9 g/day, respectively) and rose on feeding by a similar degree (median 29 and 24%). The fasting fibrinogen total synthetic rate was significantly higher in cancer patients than in controls (median 3.3 vs. 1.0 g/day, P = 0.0019). In cancer patients in the fed state, fibrinogen synthetic rate rose by a median of 38% (P = 0.012), whereas in controls there was no significant change. These findings demonstrate significant upregulation by feeding of acute-phase protein synthesis in cachectic cancer patients.

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Section: Discussionsupporting

confidence: 91%

Liver export protein synthetic rates are increased by oral meal feeding in weight-losing cancer patients

Barber

Fearon

McMillan

et al. 2000

American Journal of Physiology-Endocrinology and Metabolism

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“…Furthermore, earlier studies, primarily in animals, have shown decreased albumin synthesis rates under these conditions [7,8]. after stress hormone infusion [9], in conjunction with surgery [10], as well as in critical illness [11][12][13][14]. after stress hormone infusion [9], in conjunction with surgery [10], as well as in critical illness [11][12][13][14].…”

Section: Introductionmentioning

confidence: 96%

Albumin synthesis in humans increases immediately following the administration of endotoxin

et al. 2002

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In order to investigate the immediate (i.e. within 3 h) response of albumin synthesis to the administration of endotoxin, as a model of a moderate and well controlled catabolic insult, two measurements employing L-[(2)H(5)]phenylalanine were performed in 16 volunteers. One group ( n =8) received an intravenous injection of endotoxin (4 ng/kg; lot EC-6) immediately after the first measurement of albumin synthesis, whereas the other group received saline. A second measurement was initiated 1 h later. In the endotoxin group, the fractional synthesis rate of albumin was 6.9+/-0.6%/day (mean+/-S.D.) in the first measurement. In the second measurement, a significant increase was observed (9.6+/-1.2%/day; P <0.001). The corresponding values in the control group were were 6.6+/-0.6%/day and 7.0+/-0.6%/day respectively (not significant compared with first measurement and P <0.001 compared with the second measurement in the endotoxin group). The absolute synthesis rates of albumin were 148+/-35 and 201+/-49 mg x kg(-1) x day(-1) before and after endotoxin ( P <0.01). In the control group, the corresponding values were 131+/-21 and 132+/-20 mg x kg(-1) x day(-1) (not significant compared with the first measurement and P <0.01 compared with the second measurement in the endotoxin group). In conclusion, these results indicate that albumin synthesis increases in the very early phase after a catabolic insult, as represented by the administration of endotoxin.

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“…However, in recent years, several reports have been presented showing increased rates of albumin synthesis in catabolic states, e.g. after stress hormone infusion [9], in conjunction with surgery [10], as well as in critical illness [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Albumin synthesis in humans increases immediately following the administration of endotoxin

Barle¹,

JANUSZKIEWICZ²,

HÅLLSTRM³

et al. 2002

Clinical Science

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In order to investigate the immediate (i.e. within 3 h) response of albumin synthesis to the administration of endotoxin, as a model of a moderate and well controlled catabolic insult, two measurements employing L-[ 2 H 5 ]phenylalanine were performed in 16 volunteers. One group (n l 8) received an intravenous injection of endotoxin (4 ng/kg ; lot EC-6) immediately after the first measurement of albumin synthesis, whereas the other group received saline. A second measurement was initiated 1 h later. In the endotoxin group, the fractional synthesis rate of albumin was 6.9p0.6 %/day (meanpS.D.) in the first measurement. In the second measurement, a significant increase was observed (9.6p1.2 %/day ; P 0.001). The corresponding values in the control group were were 6.6p0.6 %/day and 7.0p0.6 %/day respectively (not significant compared with first measurement and P 0.001 compared with the second measurement in the endotoxin group). The absolute synthesis rates of albumin were 148p35 and 201p49 mg : kg − 1 : day − 1 before and after endotoxin (P 0.01). In the control group, the corresponding values were 131p21 and 132p20 mg : kg − 1 : day − 1 (not significant compared with the first measurement and P 0.01 compared with the second measurement in the endotoxin group). In conclusion, these results indicate that albumin synthesis increases in the very early phase after a catabolic insult, as represented by the administration of endotoxin.

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Effect of surgery on albumin synthesis rate in humans

Cited by 4 publications

References 0 publications

Liver export protein synthetic rates are increased by oral meal feeding in weight-losing cancer patients

Liver export protein synthetic rates are increased by oral meal feeding in weight-losing cancer patients

Albumin synthesis in humans increases immediately following the administration of endotoxin

Albumin synthesis in humans increases immediately following the administration of endotoxin

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