Effect of Surgical Modality and Hypofractionated Split-course Radiotherapy on Local Control and Survival from Sinonasal Mucosal Melanoma

Thariat, Juliette; Poissonnet, G.; Marcy, Pierre-Yves; Lattes, Leone; Butori, Catherine; Guevara, N.; Dassonville, O.; Santini, J.; Bensadoun, R.J.; Castillo, L.

doi:10.1016/j.clon.2011.04.013

Cited by 41 publications

(23 citation statements)

References 31 publications

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“…On peut cependant relever que les recommandations actuelles préconi-sent une radiothérapie indépendamment de l'étendue et de l'épaisseur de la lésion. Certains mélanomes de la cavité nasale localisés pourraient peut-être être contrôlés par chirurgie seule, itérative en cas de récidive locale [37]. En adjuvant, l'irradiation repose sur un fractionnement classique de 1,8 à 2 Gy par fraction jusqu'à 60-70 Gy en 6 à 7 semaines par radiothérapie conformationnelle, si possible avec modulation d'intensité en raison de la proximité d'organes à risque.…”

Section: Radiothérapieunclassified

Mélanomes muqueux de la tête et du cou : état actuel des pratiques et controverses

et al. 2015

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Section: Radiothérapieunclassified

Mélanomes muqueux de la tête et du cou : état actuel des pratiques et controverses

et al. 2015

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“…1,2 Two-thirds of lesions arise in the nasal cavity and paranasal sinuses, an additional one-quarter arise in the oral cavity, with the remainder occurring at other sites. 3 Unfortunately, because of the lack of visibility and relative asymptomatic nature of small lesions, mucosal melanoma of this region is often diagnosed at more advanced stages.…”

Section: Introductionmentioning

confidence: 99%

“…Overall 5 year survival rates for this patient population is usually poor (<50%), with presentation usually 10-20 years later than cutaneous melanoma. 2,4,5 The presenting symptoms are usually epistaxis and/or nasal obstruction.…”

Section: Introductionmentioning

confidence: 99%

“…Surgical resection, with adequate margins, is the usual treatment of choice when there is local disease. 1,2,4,7 As many patients may present with locally advanced disease, full staging prior to surgical intervention is recommended. Because of the anatomic challenge that melanoma of this origin can pose, post-operative radiotherapy is usually recommended, especially for patients in which clear surgical margins are unable to be achieved, however given lack of randomized data, this remains highly individualized with varying outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Rare Presentations of Primary Melanoma and Special Populations

Kottschade¹,

Grotz²,

Dronca³

et al. 2014

American Journal of Clinical Oncology

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A subset of patients with melanoma present in rare and unique clinical circumstances requiring specific considerations with respect to diagnostic and therapeutic interventions. Herein we present our review of patients with: (1) primary mucosal melanoma of the head and neck, gastrointestinal and genitourinary tracts; (2) primary melanoma of the eye; (3) desmoplastic melanoma; (4) subungual melanoma; (5) melanoma in special populations: children, non-Caucasians, as well as a discussion of familial melanoma.

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“…Overall survival for HNMM has ranged between 49.5% and 64.7% at 2 years and between 20% and 51.5% at 5 years in the most recent series. 13,16,20,21,[26][27][28][29][30] HNMM, and particularly SNMM, are primarily impacted by advanced T stage and the presence of regional metastases. 15,19,21,28 Additionally, the presence of distant metastasis at the time of diagnosis is also a bad prognostic factor.…”

Section: Institution Yearsmentioning

confidence: 99%

Sinonasal mucosal melanomas in Quito, Ecuador

Pacheco-Ojeda¹

2017

Int Surg J

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Background: Head and neck mucosal melanoma account for 2 to 8% of head and neck melanomas, the majority of which arises in the nasal cavity or paranasal sinuses. The aim of this report was to review our experience on sinonasal malignant melanomas (SNMM) treated over a long period of time at a tertiary referral hospital.Methods: Clinical records of all of the patients operated on for SNMM at the Social Security Hospital and private clinics in Quito, Ecuador, were reviewed. Nineteen patients had histologically proven diagnosis. Eleven patients were men and mean age was 64. The most common presenting symptoms were nasal obstruction and epistaxis. Most tumors were located at the nasal fossa. Extranasal extension was present in 11 patients. Twelve had stage III- IV tumors. All patients were treated by surgery. Postoperative radiotherapy was given to 7.Results: Local recurrence (11 events) occurred in 9 cases. These 11 events were treated with surgery in 8, eventually associated to radiation therapy (RT) and chemotherapy (CT). Eight out of these 9 patients died. Five overall survival was 46%. Death was related to local disease and distant metastases. All stage I tumor patients are alive.Conclusions: Most sinunasal melanomas have a poor prognosis, mainly attributed to initial advanced local disease, local recurrence and distant metastasis. Surgery is the mainstay treatment, followed by radiotherapy, according to the T category.

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Effect of Surgical Modality and Hypofractionated Split-course Radiotherapy on Local Control and Survival from Sinonasal Mucosal Melanoma

Cited by 41 publications

References 31 publications

Mélanomes muqueux de la tête et du cou : état actuel des pratiques et controverses

Mélanomes muqueux de la tête et du cou : état actuel des pratiques et controverses

Rare Presentations of Primary Melanoma and Special Populations

Sinonasal mucosal melanomas in Quito, Ecuador

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