Effect of Surgical Periodontal Therapy on Serum C-reactive Protein Levels Using ELISA in Both Chronic and Aggressive Periodontitis Patient

Gupta, Bharat; Sawhney, Anshul; Patil, Neha; Yadav, Manoj Kumar; Tripathi, Shashank; Sinha, Saurabh; Sharma, Saurabh; Gupta, Saurabh

doi:10.7860/jcdr/2015/14680.6558

Cited by 12 publications

(11 citation statements)

References 22 publications

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“…One study ( 18 ) demonstrated that CRP levels increase with the severity of periodontitis. Cases of very progressive and extensive periodontitis are associated with higher CRP levels ( 12 , 13 , 15 , 19 - 21 ). As regards periodontal therapy, however, intervention studies show discrepancies whether periodontal treatment has an impact on the reduction of serum CRP levels ( 14 , 15 , 21 - 23 ).…”

Section: Discussionmentioning

confidence: 99%

Association between periodontitis and serum c-reactive protein levels

et al. 2020

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Background Periodontal disease may be associated with more bacteria and consequent induction of a systemic inflammatory process, with changes in the levels of C-reactive protein (CRP). The purpose of this cross-sectional study was to evaluate the association between periodontitis and serum levels of C-reactive protein. Material and Methods The sample comprised 100 individuals distributed into two groups according to serum levels of C-reactive protein: normal or altered. Social, biological and behavioral data were collected by means of a structured questionnaire. Additionally, a blood test was requested to measure C-reactive protein levels. CRP values less than 3 mg/l were considered normal. Periodontal clinical examination was conducted in each participant for analysis of probing depth, bleeding on probing and clinical attachment level. Descriptive statistics, univariate analysis and logistic regression were performed. Results were provided in odds ratio, confidence intervals and p values. Results Individuals with altered C-reactive protein levels showed a higher prevalence of periodontitis than individuals with normal C-reactive protein levels ( p =0.008). In the final logistic regression model, individuals with periodontitis were more likely to present altered C-reactive protein than individuals without periodontitis (OR=3.27, CI=1.42-7.52, p =0.005). Conclusions The alteration of the C-reactive protein levels among individuals with a higher prevalence of periodontitis corroborates clinical evidence that periodontal infection has a systemic impact. Key words: C-reactive protein, cytokines, periodontal diseases, periodontitis.

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Section: Discussionmentioning

confidence: 99%

Association between periodontitis and serum c-reactive protein levels

et al. 2020

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“…Finally, we can conclude that the Improvement of periodontal condition is found to be associated with reduction in TNF-α levels and that phase 1 periodontal therapy for gestational diabetic females is a safe & effective line of treatment. More research on the biological effects of TNF-α should be considered and further studies are needed to understand the role of TNF-α in periodontal health and disease [65][66][67][68][69][70].…”

Section: Correlation Of Tnf-α (Gcf)mentioning

confidence: 99%

Evaluation of Level of TNF-α in Chronic Periodontitis Patients with Gestational Diabetes Mellitus after Phase I Periodontal Therapy

Elkadi¹,

Madkour²,

El-Menoufy³

et al. 2018

Dentistry

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the healthy periodontium. It contains different substances including: immunoglobulin, microorganisms, toxins, cells, and lysosomal enzymes and markers. GCF is regarded as a window for non-invasive analysis of periodontal [11-14] conditions, including markers of connective tissue and bone destruction. Evaluation of the molecular markers of tissue destruction in serum was sought to clarify the possible interactions between periodontitis and various systemic diseases and conditions such as gestational diabetes mellitus GDM and adverse pregnancy outcomes). Serum provides information about the inflammatory stimulus and the response generated in circulation towards the periodontal [15,16]. Pathogens that colonize the sub-gingival area. The present study was conducted to evaluate the levels of TNF-α in GCF and serum in chronic periodontitis patients with or without GDM before and after phase I (non-surgical) periodontal therapy and its correlation to periodontal clinical parameters.

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“…Individuals with periodontitis have increased systemic levels of acute‐phase proteins, plasma antibody levels, coagulation factor, total white blood cell count, neutrophils, C‐reactive protein (CRP), and several cytokines (Moshage, 1997; Ebersole & Cappelli, 2000; Grupta et al, 2015). Increased serum neutrophil elastase and CRP caused by periodontitis may link periodontal and systemic diseases (cardiovascular disease, ischaemic stroke, and chronic obstructive pulmonary diseases; Ramich et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Its levels in healthy individuals are about 100 mg/L in the presence of overwhelming systemic infections (Moshage, 1997). This provides a useful matter in tracking the course of infections (Kanaparthy et al, 2012; Gupta et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of compliance during periodontal maintenance therapy on c‐reactive protein levels: a 6‐year follow‐up

Costa

Lima

Cortelli

et al. 2020

J Clinic Periodontology

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Aims To longitudinally evaluate the effects of compliance during periodontal maintenance therapy (PMT) on C‐reactive protein (CRP) levels and its relation to periodontal status. Materials and Methods A subsample comprising of 30 matched pairs was taken from a previous 6‐year longitudinal study under PMT. Pairs were composed of one regular (RC) and one irregular (IC) compliers, matched by age and sex. Periodontal parameters and plasma samples were collected at 3 times: T1[prior to active periodontal therapy (APT)], T2(after APT), and T3(after 6 years). CRP plasma levels were quantified using ELISA. Results RC presented better clinical periodontal status, lower recurrence of periodontitis (sites with PD ≥4 mm and CAL ≥3 mm, together with the persistence and/or presence of BOP and/or suppuration, during any of the subsequent recall evaluations) and significant reductions in CRP levels over time [(T1: RC = 3.64 ± 2.13 and IC = 3.92 ± 2.02 mg/L) and (T3: RC = 2.12 ± 1.39 mg/L and IC = 3.71 ± 1.82 mg/L)]. Logistic regression analysis demonstrated that individuals with periodontitis recurrence presented 2.19 higher chances of presenting altered CRP levels (values ≥3 mg/L‐ T2 to T3) than those without periodontitis recurrence (95%CI:1.16–3.27; p = 0.017). Conclusions Higher CRP plasma levels were associated with higher recurrence of periodontitis and worse clinical periodontal parameters among IC when compared to RC.

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Effect of Surgical Periodontal Therapy on Serum C-reactive Protein Levels Using ELISA in Both Chronic and Aggressive Periodontitis Patient

Abstract: Successful periodontal treatment results in significant decrease in serum C-reactive protein (CRP) levels in otherwise healthy subjects.

Cited by 12 publications

References 22 publications

Association between periodontitis and serum c-reactive protein levels

Association between periodontitis and serum c-reactive protein levels

Evaluation of Level of TNF-α in Chronic Periodontitis Patients with Gestational Diabetes Mellitus after Phase I Periodontal Therapy

Effect of compliance during periodontal maintenance therapy on c‐reactive protein levels: a 6‐year follow‐up

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