Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis

Seyyedi, Javad; Alizadeh, Shahab

doi:10.1007/s11695-020-04710-1

Cited by 6 publications

(8 citation statements)

References 51 publications

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“…The observed evidence for publication bias may resulted from chance, poor methodological quality resulting to spuriously inflated impacts in smaller papers, true heterogeneity, in which effect size differs based on the study size (eg, due to differences in the intensity of exposure), and artefactual in which sampling variation can lead to an relationship between the exposure effect and its standard error. 56 Moreover, as another limitation, completely included original studies evaluating dietary consumption by means of self-exposure and were prone to assessment errors. Because most of the studies were assessed through selfreported dietary questionnaires, misclassification of GI and GL levels of foods is inevitable.…”

Section: Discussionmentioning

confidence: 99%

Glycemic index, but not glycemic load, is associated with an increased risk of metabolic syndrome: Meta‐analysis of observational studies

et al. 2021

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Background: Diets with high glycemic index (GI) or high glycemic load (GL) have been linked to important risk factors associated with the development of metabolic syndrome (MetS), such as dyslipidemia, higher blood glucose, and insulin concentrations.However, the role of GI and GL in relation to Mets is still understudied and controversial. This review, therefore, assessed whether high GI or GL contribute to development of Mets.Methods: A systematic search of four bibliographic databases was conducted (MEDLINE/PubMed, EMBASE, Web of Sciences, and Scopus) from inception to January 2020 for observational studies assessing GI/GL in relation to MetS. Risk estimates were pooled using random-effect models for the highest versus lowest intake categories, and assessed for heterogeneity using subgroup analysis. The doseresponse nature of the relationship was also investigated. Sensitivity analysis and Egger test were used to check the robustness of findings and the possibility of publication bias, respectively.Results: Data from 12 publications (one cohort study and eleven cross-sectional studies) with a total sample size of 36,295 subjects are included. The pooled effect sizes from the nine studies indicated high versus low dietary GI was associated with increased risk of MetS (OR = 1.05, 95% CI: 1.01 to 1.09) (I 2 = 58.1, P = .004). This finding was supported by all subgroup analyses except where studies used 24-h recalls for dietary assessment. Additionally, a linear dose-response investigation revealed that each 5-point increment in GI was associated with 2% increase in the risk of MetS (OR = 1.02, 95% CI: 1.01 to 1.02); non-linear pattern was insignificant, however (p-nonlinearity = 0.63). Moreover, pooled effect sizes from ten studies suggested that no association was found between the GL and MetS with results remaining consistent in all subgroup analyses. Conclusion:A diet with lower GI may protect against MetS. Nutrition policy and clinical practices should encourage a diet with low GI. Future studies should include both GI and GL and different criteria of MetS to provide a better comparison.

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Section: Discussionmentioning

confidence: 99%

Glycemic index, but not glycemic load, is associated with an increased risk of metabolic syndrome: Meta‐analysis of observational studies

et al. 2021

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“…This might be the answer as to why no association between the changes in BMI and absolute difference in MCP-1 levels could be found. However, various mechanisms other than decreased fat tissue mass, such as decreased inflammation, decreased nutrient absorption, lower energy intake, or decreased need for the liver to detoxify ingested drugs, might have an impact on circulating MCP-1 levels as well [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis

Jamialahmadi

Abbasifard

Reiner

et al. 2022

JCM

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Background: MCP-1 (monocyte chemoattractant protein) plays an important role in early phases of atherogenesis as well as in plaque destabilization, which causes cardiovascular events to play an important role in low-grade inflammation. Obesity, particularly extreme obesity, is a pivotal risk factor for atherosclerosis and many other diseases. In the early stages, bariatric surgery might stop or slow atherogenesis by suppressing inflammation, but also in later stages, preventing plaque destabilization. The aim of this meta-analysis was to provide an answer as to whether bariatric surgery has a significant effect on circulating MCP-1 level or not. Methods: A systematic literature search in PubMed, Scopus, Embase, and Web of Science was performed from inception to 1 January 2022. Meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V2 software. In order to heterogeneity compensation of studies in terms of study design and treatment duration, the characteristics of the studied populations random-effects model and the generic inverse variance weighting method were used. To investigate the relationship with the estimated effect size, a random-effect meta-regression model was used. To assess the exitance of publication bias in the meta-analysis, the funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used. Results: Meta-analysis of 25 studies with 927 subjects included demonstrated a significant decrease of MCP-1 concentration after bariatric surgery. The data of meta-regression did not indicate any association between the alterations in body mass index (BMI) and absolute difference in MCP-1 levels, but a linear relationship between the changes in MCP-1 and length of follow-up was proven. Conclusions: Bariatric surgery significantly decreases MCP-1 concentration, but there was no association between the changes in BMI and absolute difference in MCP-1 levels before and after the surgery.

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“…95,[102][103][104] A systematic review and pooled meta-analysis of 29 studies with 1123 participants have demonstrated a significant reduction in markers of systemic inflammation and an improvement in endothelial function after BS in individual with and without diabetes. 105 BS also reverses obesity-induced small artery vessel dysfunction and restores the anticontractile activity of perivascular adipose tissue due to reduced local adipose tissue inflammation and oxidative stress and improved adiponectin and nitric oxide bioavailability. 106…”

Section: The Role Of Adipose Tissue In Obesity-related Comorbiditiesmentioning

confidence: 98%

“…We have previously demonstrated improvements in lipid parameters, pro‐atherosclerotic lipoproteins, HDL function, insulin resistance, and mediators of systemic, subcutaneous adipose tissue and vascular inflammation 6 and 12 months after BS 95,102–104 . A systematic review and pooled meta‐analysis of 29 studies with 1123 participants have demonstrated a significant reduction in markers of systemic inflammation and an improvement in endothelial function after BS in individual with and without diabetes 105 . BS also reverses obesity‐induced small artery vessel dysfunction and restores the anticontractile activity of perivascular adipose tissue due to reduced local adipose tissue inflammation and oxidative stress and improved adiponectin and nitric oxide bioavailability 106 …”

Section: The Role Of Adipose Tissue In Obesity‐related Comorbiditiesmentioning

confidence: 99%

Microvascular complications of obesity and diabetes—Role of bariatric surgery

et al. 2023

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SummaryBariatric surgery in people with obesity can lead to long‐term remission of type 2 diabetes mellitus (T2DM) and a reduction in the incidence of macrovascular complications. The impact of bariatric surgery on microvascular complications is less clear. In this narrative review, we sought to evaluate the effect of bariatric surgery on microvascular complications in patients with and without diabetes. The risk of developing microvascular complications is increased in people with obesity, and this is amplified in those with T2DM. The impact of metabolic surgery on microvascular complications is limited to a subgroup analysis of studies or statistical modeling to predict the glycemia‐independent effect of bariatric surgery. While bariatric surgery halts the progression of retinopathy in those with minimal retinopathy, it may worsen in those with advanced retinopathy. Bariatric surgery improves proteinuria and major renal outcomes, regardless of the severity of renal impairment. Bariatric surgery in patients with obesity with or without diabetes is associated with an improvement in neuropathic symptoms and regeneration of small nerve fibers. In conclusion, bariatric surgery is associated with an improvement in microvascular complications. Further studies are needed to elucidate the underlying mechanisms for the favorable effect of bariatric surgery on microvascular outcomes.

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Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis

Cited by 6 publications

References 51 publications

Glycemic index, but not glycemic load, is associated with an increased risk of metabolic syndrome: Meta‐analysis of observational studies

Glycemic index, but not glycemic load, is associated with an increased risk of metabolic syndrome: Meta‐analysis of observational studies

The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis

Microvascular complications of obesity and diabetes—Role of bariatric surgery

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