Effect of Sweet Persimmon Wine on Alcoholic Fatty Livers in Rats

Abstract

Persimmons are shown to contain high levels of phenolics. The present study was designed to investigate if a sweet persimmon wine (SPW) would affect the development of alcoholic fatty liver in rats. Initially, male Sprague-Dawley rats were housed singly in stainless steel wire-bottomed cages in a room of controlled temperature and lighting. The rats had free access to a nutritionally adequate AIN-93G diet and deionized water. After the acclimatization period, rats were weight-matched and assigned to the following three groups: two groups were fed 6.7% ethanol or the caloric equivalent of maltose-dextrin in a Lieber-DeCarli diet and the other group was fed the isocaloric Lieber-DeCarli diet containing SPW at the same ethanol level. All three groups were fed their respective diets for 6 weeks. Serum transaminase, cholesterol, and triglyceride levels were measured. Liver lipids and histology were assessed at 6 weeks. The total phenolic content and the antioxidant and free radical scavenging activities of SPW were determined. SPW significantly increased antioxidant and free radical scavenging activities. As markers of liver injury, serum alanine and aspartate transminases were markedly lowered by SPW at 6 weeks. SPW significantly reduced the serum levels of serum cholesterol and triglyceride compared to ethanol treatment. SPW delayed the development of an alcoholic fatty liver by reversing fat accumulation in the liver, as evidenced in histological observations. Taken together, SPW seems to protect the liver from becoming fatty by alleviating fatty liver symptoms and lowering hepatic and serum lipid levels. Such a protective effect of SPW appears to be in part due to its phenolics.

In vivo antioxidant activity of mackerel (Scomber japonicus) muscle protein hydrolysate

“…However, there were no significant changes in body weight, organ or tissue weight, or relative liver and epididymal white adipose tissue weight with different experimental treatments except in the M100 group, which showed reduced kidney weight compared to the intact control group. Similar to our study, Nam et al (2011), Bertola et al (2013), and Donepudi et al (2018) reported a weight-losing tendency in animals fed the Lieber-DeCarli ethanol diet. Brien et al (2011) also reported on the effects of sustained ethanol intake on the ethanol oxidation system and ATP production, which led to weight loss.…”

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

“…Many in vitro and in vivo studies confirmed that fruits such as the mango [ 144 ], grape [ 145 ], blueberry [ 110 ], mulberry [ 146 ], persimmon [ 147 ], pomegranate [ 148 ], cranberry [ 149 ], and wolfberry [ 150 ] play an important role against ALD. This ameliorative effect on ALD was mainly due to the presence of a tangible amount of bioactive compounds in fruits.…”

“…Many other fruits such as apricot [ 162 ], guava [ 163 ], pomegranate [ 148 ], lemon [ 164 ], Citrus depressa [ 165 ], noni fruit [ 166 ], Opuntia ficus indica [ 167 ], jujube [ 168 ], and persimmon [ 147 ] were also reported to mitigate ALD. These findings confirm that daily intake of fruits may be an effective strategy for alleviating ALD.…”