Effect of Swimming Exercise to Cardiac PGC-1 α and HIF-1 α Gene Expression in Mice

Sylviana, Nova; Helja, Niswan; Qolbi, Hadaral Hudanul; Goenawan, Hanna; Lesmana, Ronny; Syamsunarno, Mas Rizky Anggun Adipurna; Agustina, Hasrayati; Tiksnadi, Badai Bhatara; Megantara, Imam; Tarawan, Vita Murniati; Setiawan, Setiawan; Hernowo, Bethy S.; Supratman, Unang; Purba, Ambrosius

doi:10.5812/asjsm.65079

Cited by 9 publications

(13 citation statements)

References 23 publications

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“…It plays a key role in the development of increased mitochondrial density, which boosts the ATP production e ciency. In cardiac myocytes after training [39], swimming [40,41], and running [42] both would increase PGC-1α expression in rat myocardium. Many studies have shown that the limited capacity of cardiac cells to regenerate increases with endurance training such as running and swimming [43,44].…”

Section: Discussionmentioning

confidence: 94%

Endurance training and MitoQ supplementation increases PERM1 and SMYD1 gene expression and improves hemodynamic parameters in cardiac muscle of male Wistar rats

Tezarji,

Moflehi,

Nikooie

et al. 2022

Preprint

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The histone methyltransferase (SMYD1) and the muscle-specific protein (PERM1) play an important role in maintaining cardiac energetics and function. The present study aimed to examine the effect of two types of endurance training (running and swimming) plus MitoQ supplementation on gene expression of PERM1 and SMYD1 plus hemodynamic parameters in the cardiac muscle of male Wistar rats. The animals underwent MitoQ supplementation or endurance training or endurance training + MitoQ supplementation for eight weeks. Gene expression of PERM1 and SMYD1, measured by Real Time-PCR and quantified by 2−∆∆CT method, and hemodynamic parameters were compared between groups using two-way multivariate analysis of variance. Cardiac gene expression of PERM1 and SMYD1 increased significantly through running (PERM1, P < 0.05; SMYD1, P < 0.01), swimming (PERM1, P < 0.05; SMYD1, P < 0.05). and MitoQ supplementation (PERM1, P < 0.001). The effects of MitoQ supplementation were additive to both running and swimming effects on cardiac gene expression of (PERM1, P < 0.001; SMYD1, P < 0.05). Swimming-induced enhancement in cardiac expression of PERM1 and SMYD1 was associated with a significant increase in ± dP/dt max (P < 0.05)). In conclusion, expression of genes involved in cardiac metabolism can be affected by endurance training and this effect could be improved through MitoQ supplementation.

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Section: Discussionmentioning

confidence: 94%

Endurance training and MitoQ supplementation increases PERM1 and SMYD1 gene expression and improves hemodynamic parameters in cardiac muscle of male Wistar rats

Tezarji,

Moflehi,

Nikooie

et al. 2022

Preprint

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show abstract

“…Additionally, 4 weeks of HIIT consisting of running exercise also increased HIF-1α content in the cardiac tissue of hypertensive rats ( Holloway et al, 2015 ). However, other studies have suggested that HIF-1α content decreases in response to exercise training ( Pinho et al, 2012 ), or remains unchanged ( Sylviana et al, 2018 ). These discrepancies might be due to model-specific factors, such as the program of exercise and animal strain.…”

Section: Exercise-induced Oxygen Metabolism Changes In Cardiomyocyte Regenerationmentioning

confidence: 99%

“…PGC-1α is essential for mitochondrial density increment to ameliorate the efficiency of ATP production by reducing mitochondrial respiration in cardiomyocyte after exercise training ( Watson et al, 2007 ; Wang et al, 2020 ). The concentration of PGC-1α is upregulated in the myocardium of mice by swimming ( Sylviana et al, 2018 ) and running ( Li et al, 2011 ) exercises. The promotion of AMPK/PGC-1α signal transduction induced by treadmill running is related to decreased ROS accumulation in the rat myocardium ( Wang et al, 2020 ).…”

Section: Exercise-induced Oxygen Metabolism Changes In Cardiomyocyte Regenerationmentioning

confidence: 99%

The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration

Zhou

et al. 2021

Front. Cell Dev. Biol.

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During heart failure, the heart is unable to regenerate lost or damaged cardiomyocytes and is therefore unable to generate adequate cardiac output. Previous research has demonstrated that cardiac regeneration can be promoted by a hypoxia-related oxygen metabolic mechanism. Numerous studies have indicated that exercise plays a regulatory role in the activation of regeneration capacity in both healthy and injured adult cardiomyocytes. However, the role of oxygen metabolism in regulating exercise-induced cardiomyocyte regeneration is unclear. This review focuses on the alteration of the oxygen environment and metabolism in the myocardium induced by exercise, including the effects of mild hypoxia, changes in energy metabolism, enhanced elimination of reactive oxygen species, augmentation of antioxidative capacity, and regulation of the oxygen-related metabolic and molecular pathway in the heart. Deciphering the regulatory role of oxygen metabolism and related factors during and after exercise in cardiomyocyte regeneration will provide biological insight into endogenous cardiac repair mechanisms. Furthermore, this work provides strong evidence for exercise as a cost-effective intervention to improve cardiomyocyte regeneration and restore cardiac function in this patient population.

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“…Exercise condition increases oxygen demand which is required in muscle contraction (6). Glycolytic system is one of the most important energy supplies of skeletal muscles during highly intense exercise under anaerobic performance in sport.…”

Section: Introductionmentioning

confidence: 99%

“…Glycolytic system is one of the most important energy supplies of skeletal muscles during highly intense exercise under anaerobic performance in sport. This imbalance condition between the amounts of oxygen demand and supply in body is named hypoxia (6). There is a hypothesis that continuous exercise training induced hypoxia, as a bene cial muscular adaptations, would result in induce included increased expression of genes that codes glycolysis enzymes (7).…”

Section: Introductionmentioning

confidence: 99%

Comparison of HIF1 Gene Polymorphism (Rs11549465) Among Elite and Amateur Power Athletes Versus Non-athletes

Batavani¹,

Ghaedi²

2020

Preprint

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Background: One of the major energy systems for power performance in muscles is glycolysis that is regulated by the levels of Hypoxia-inducible factor-1α (Hif1) which in response to hypoxia act as a transcription factor. The goal of this survey was the comparison of HIF1 gene polymorphism (rs11549465) among elite and amateur power karate-kas versus non-athletes. Methods and Results: The C/T polymorphism allelic and genotypic's distribution of Hif1 rs11549465 gene was determined in this survey throughout 550 healthy Iranian subjects that divided in power karate-kas groups that sub-divided into elite (86 male and 86 female) and amateur karate-kas (100 male and 72 female) versus 206 individuals in non-athlete group (100 male and 106 female). After obtaining the written consent of all participants in the study, in seated mode, at a given time and in the diagnostic-laboratory, the amount of 5cc blood from brachiocephalic vein was taken. The Hif1 gene T/C polymorphism was assessed with PCR by using the forward and the overturn primers. Amplicons, the length were treated with the restriction endonuclease Hph I (Enzyme). Also RFLP were analyzed by electrophoresis separation on 1% agarose gel. Non–parametric Chi-Square and multinomial regression tests were used for assess the differences through the SPSS software and the P value less than 0.05 was considered as a significant different. Chi-square test showed genotype frequencies of Hif1 TC rs11549465 (TC genotype: 25.6% vs. TT genotype: 11.4%; CC genotype: 63%) were significantly different in these population (χ2= 99.889, P=0.000). Furthermore, the results of multiple regressions demonstrated that there isn’t general linear relationship between Hif1 gene expression and power ability of karate-kas. Conclusions: From the genetic talent aspect, there wasn't any correlation between Hif1 gene expressions with Iranian karate competitor’s levels.Key Points: Genetic and environmental factors have a great influence over components of the athletic performance such as power/ strength traits. Genetic markers may increase comprehension of athlete talent. There wasn't any correlation between Hif1 gene expressions with Iranian karate competitor’s levels.

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Effect of Swimming Exercise to Cardiac PGC-1 α and HIF-1 α Gene Expression in Mice

Cited by 9 publications

References 23 publications

Endurance training and MitoQ supplementation increases PERM1 and SMYD1 gene expression and improves hemodynamic parameters in cardiac muscle of male Wistar rats

Endurance training and MitoQ supplementation increases PERM1 and SMYD1 gene expression and improves hemodynamic parameters in cardiac muscle of male Wistar rats

The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration

Comparison of HIF1 Gene Polymorphism (Rs11549465) Among Elite and Amateur Power Athletes Versus Non-athletes

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