Effect of Sympathetic Stimulation on Inactive Renin

Leeuw, Peter W. de; Bos, R. De; Soest, G. A. W. Van; Willemse, Pierre J.; Wh, Birkenhäger

doi:10.3109/10641968209062390

Clinical and Experimental Hypertension. Part A: Theory and Prac

1982

DOI: 10.3109/10641968209062390

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Effect of Sympathetic Stimulation on Inactive Renin

Peter W. de Leeuw

R. De Bos

G. A. W. Van Soest

et al.

Abstract: ABS TRACTIn the present study we investigated the effect of three manoeuvres known to be associated with enhanced sympathetic activity on plasma levels of active and inactive renin. To this end, active and trypsin-activatable renin were measured in blood drawn from 12 untreated essential hypertensive patients before, during and after any of the following tests: isometric exercise (handgrip), noise stimulation and 45O head-up tilt.These studies were repeated after the patients had been treated with either ateno… Show more

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Effect of sympathetic stimulation and intrarenal alpha‐blockade on the secretion of renin by the human kidney

Leeuw

Bos

et al. 1985

Eur J Clin Investigation

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This study was initiated to explore the possible involvement of renal alpha-adrenoceptors in the regulation of active and inactive renin. In fifteen hypertensive patients who proved not to have vascular abnormalities on diagnostic renal arteriography, blood samples were collected simultaneously from the renal artery and vein before and during an intrarenal infusion of either saline (n = 5), or the alpha-1 blocker doxazosin (n = 5) or the non-selective alpha-1 blocker doxazosin (n = 5) or the non-selective alpha-blocker phentolamine (n = 5). Subsequently, responses of renal blood flow and renin secretion were assessed following 3 min of handgrip exercise. In none of the experiments secretion of inactive renin could be detected. Release of active renin increased from 580 (SEM 170) to 650 (SEM 220) microU min-1 (100 g)-1 during infusion of doxazosin (P less than 0.05) and from 760 (SEM 100) to 1000 (SEM 340) microU min-1 (100 g)-1 during infusion of phentolamine (P less than 0.01). Saline infusion had no effect on secretion of active renin. While handgrip exercise had no significant effect on active renin secretion in the saline and in the doxazosin group, it enhanced secretion from 1000 (SEM 340) to 1280 (SEM 390) microU min-1 (100 g)-1 in the phentolamine group (P less than 0.01). The results indicate that mainly alpha-2 adrenoceptors exert an inhibitory effect on release of active renin, although alpha-1 receptors participate to some degree. There is no evidence that the kidney secretes inactive renin.

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Effect of sympathetic stimulation and intrarenal alpha‐blockade on the secretion of renin by the human kidney

Leeuw

Bos

et al. 1985

Eur J Clin Investigation

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Β‐adrenoceptor Mediated Secretion of Active and Inactive Renin in Conscious Sheep

Kattan

Parker

Noble

1990

Clin Exp Pharma Physio

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1. Beta-adrenoceptor linked regulation of plasma active and inactive renin was investigated in sheep with indwelling artery, vein and bladder catheters. Concurrent changes in renal function were also monitored. 2. The beta-adrenoceptor agonist isoprenaline (bolus intravenous (i.v.) dose 0.5 mg/kg, 0.05 microgram/kg per min) increased plasma active renin concentration within 15 min and reached a plateau increase of 306%. Initially plasma inactive renin remained unchanged but after 105 min it decreased. 3. The non-selective beta-adrenoceptor antagonist propranolol (bolus i.v. dose 4 mg/kg, 40 micrograms/kg per min) did not significantly alter basal plasma active renin but selectively reduced inactive renin. The absence of any change in active renin may reflect the relatively low level of stress-induced sympathetic activation in these conscious animals compared to equivalent studies carried out on human subjects. 4. Using the same dose schedules, propranolol completely blocked the isoprenaline-induced increases in plasma active renin secretion even though it had no effect on the basal active renin levels. 5. The selective beta 1-adrenoceptor antagonist atenolol (bolus i.v. dose 5 mg/kg) decreased basal plasma active renin by 24% (+ 135 min) but reduced plasma inactive renin by 75% compared to control. 6. Therefore, both a beta-adrenoceptor agonist (isoprenaline) and two beta-adrenoceptor antagonists (propranolol and atenolol) decreased plasma inactive renin concentration in conscious sheep. 7. These results are discussed in relation to the accompanying changes in arterial blood pressure and aspects of renal function.

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Effect of Sympathetic Stimulation on Inactive Renin

Cited by 2 publications

References 5 publications

Effect of sympathetic stimulation and intrarenal alpha‐blockade on the secretion of renin by the human kidney

Effect of sympathetic stimulation and intrarenal alpha‐blockade on the secretion of renin by the human kidney

Β‐adrenoceptor Mediated Secretion of Active and Inactive Renin in Conscious Sheep

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