Effect of symptoms on executive function in bipolar illness

Dixon, T.; Kravariti, Eugenia; Frith, Christopher D.; Murray, RM; McGuire, Philip

doi:10.1016/s0920-9964(03)80918-0

Cited by 34 publications

(39 citation statements)

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“…Overall manic patients display poorer functional cognitive abilities in verbal memory, verbal fluency, and cognitive estimation when compared with depressed and remitted patients [6]. By comparison, bipolar and unipolar depressive patients present primarily with verbal memory deficits [3,4,9,10].…”

Section: Introductionmentioning

confidence: 93%

“…While the majority of cognitive studies in BD focused on heterogeneous BD populations, a small number of crosssectional studies compared cognitive only functioning across the acute and euthymic phases of BD [6][7][8]. Overall manic patients display poorer functional cognitive abilities in verbal memory, verbal fluency, and cognitive estimation when compared with depressed and remitted patients [6].…”

Section: Introductionmentioning

confidence: 99%

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Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Cardoso

Bauer

Meyer

et al. 2015

Curr Psychiatry Rep

130

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Bipolar disorder (BD) has been associated with impairments in a range of cognitive domains including attention, verbal learning, and mental flexibility. These deficits are increased during the acute phases of the illness and worsen over the course of BD. This review will examine the literature in relation to potential mechanisms associated with cognitive decline in BD. Scopus (all databases), Pubmed, and Ovid Medline were systematically searched with no language or year restrictions, up to January 2015, for human studies that collected cross-sectional and longitudinal cognitive data in adults with BD and matched healthy controls (HC). Selected search terms were "bipolar," "cognitive," "aging," "illness duration," "onset," and "progression." Thirty-nine studies satisfied the criteria for consideration. There is evidence that cognitive function in BD is negatively associated with features of illness progression such as number of mood episodes, illness duration, and hospitalizations. Aging does not appear to affect cognitive functioning to a greater extent than in HC. Furthermore, the small number of longitudinal studies in this field does not allow to reaching firm conclusion in terms of which sub-populations would be more prone to cognitive decline in BD. The decline in cognitive abilities over the course of the BD seems to be associated with the number of episodes and number of hospitalizations. No meaningful interaction of age and bipolar disorder has been found in terms of cognitive decline. Future large-scale longitudinal studies are necessary to confirm these findings and assist in the development of preventive interventions in vulnerable individuals.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Cardoso

Bauer

Meyer

et al. 2015

Curr Psychiatry Rep

130

View full text Add to dashboard Cite

show abstract

“…The drug abuse pattern of BP patients concerns mainly stimulant drugs [550]. Cognitive impairment is reported to exist in both BP-I and BP-II patients, although more so in the bipolar I group and this is true even during the euthymic period [146,325,464]. Recent studies suggest that there is a significant degree of psychosocial impairment even when patients are euthymic and report that only a minority achieves complete functional recovery [136,211,212,279,332,359,468].…”

Section: Clinical Descriptionmentioning

confidence: 99%

Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry

Fountoulakis

Kasper

Andreassen

et al. 2012

Eur Arch Psychiatry Clin Neurosci

119

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“…Demographic and clinical data are shown in Table 1. The exclusion criteria were (1) diagnosis of schizo-affective disorder, (2) Axis I comorbidity, (3) lifetime history of substance dependence or current abuse, (4) diagnosis of neurological illness, (5) electroconvulsive therapy in the previous year, and (6) age older than 65.…”

Section: Patientsmentioning

confidence: 99%

Cognitive Functioning in Bipolar Patients Receiving Lamotrigine

Daban¹,

Martínez‐Arán²,

Torrent³

et al. 2006

Journal of Clinical Psychopharmacology

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Despite the increasing use of lamotrigine (LTG) in bipolar disorder, little is known about its impact on cognition in bipolar patients. Therefore, we have evaluated 33 bipolar I and II patients on cognitive measures (verbal memory, attention, executive functions) while receiving either LTG (n = 15) or another anticonvulsant (carbamazepine or valproate; n = 18). Patients receiving LTG were generally diagnosed as having bipolar II disorder, had experienced more depressive episodes but a lesser number of hospitalizations, and had better performance than the patients receiving carbamazepine or valproate on the verbal fluency task. A moderate effect size also suggests that both groups may differ on the immediate verbal memory test (California Verbal Learning Test). These preliminary results suggest a safer neurocognitive profile of LTG on bipolar patients, as compared with other anticonvulsants.

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Effect of symptoms on executive function in bipolar illness

Cited by 34 publications

References 0 publications

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Neuroprogression and Cognitive Functioning in Bipolar Disorder: A Systematic Review

Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry

Cognitive Functioning in Bipolar Patients Receiving Lamotrigine

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