Effect of syngeneic and xenogeneic apolipoprotein B-containing lipoproteins on immune response and phagocytosis in mice

Belokrylov, G. A.; Popova, O. Ya.; Bondar, K. V.; Denisenko, A. D.

doi:10.1007/bf02496875

Bull Exp Biol Med

1998

DOI: 10.1007/bf02496875

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Effect of syngeneic and xenogeneic apolipoprotein B-containing lipoproteins on immune response and phagocytosis in mice

G. A. Belokrylov

O. Ya. Popova

K. V. Bondar

et al.

Abstract: Apolipoprotein B-containing lipoproteins injected parenterally to CBA mice exhibit immunomodulatory activity. This activity depends on the class (very low or low density lipoproteins) and origin (syngeneic or xenogeneic) of injected lipoproteins. Lipoproteins also modulate phagocytic activity of neutrophils. In vitro lipid peroxidation impairs the immunomodulatory activity of lipoproteins.

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Cited by 4 publications

References 7 publications

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The role of volume transmission of adaptogenic signals in forming the adaptive reactions of the brain

Самойлов¹,

Mokrushin

2000

Neurosci Behav Physiol

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This review presents published data and results from our own studies providing evidence for the important role of volume, non-synaptic transmission of adaptogenic signals in the mechanisms forming the long-term adaptive reactions of the brain. The importance of chemical factors involved in volume transmission and secreted by cells in this process is discussed. Special attention is paid to peptides-possible mediators of volume transmission of adaptive-type signals. Evidence has been obtained for the presence of peptides and their role in the mechanism of development of adaptive brain reactions of different origins, especially those arising in response to tetanic stimulation of neurons and transient hypoxic stress. An original method for testing for the effects of neuromodulator factors released by cells in donor slices subjected to these treatments on recipient slices was used to show that these factors had pronounced effects on synaptic transmission and could induce long-term potentiation of synaptic transmission, protecting against functional derangements due to prolonged anoxia. Blockade of protein synthesis in donor slices subjected to adaptogenic treatments suppressed the appearance of these effects. The review concludes with a discussion of the mechanisms of interaction of the synaptic and volume transmission of signals involved in forming long-term adaptive brain reactions.

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The role of volume transmission of adaptogenic signals in forming the adaptive reactions of the brain

Самойлов¹,

Mokrushin

2000

Neurosci Behav Physiol

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Involvement of intracellular regulatory systems in the adaptive effects of transient anoxia in vitro

Semenov

Tyul'kova

Самойлов

et al. 2000

Neurosci Behav Physiol

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The involvement of the calcium and phosphoinositide intracellular regulatory systems in the molecular-cellular mechanisms of adaptation of the brain to hypoxia induced by transient anoxia were studied in slices of rat olfactory cortex. Anoxia lasting 2 min initiated the development of moderate but stable activation of intracellular regulatory systems during the reoxygenation period, with increases in binding of Ca2+ to intracellular hydrophobic domains and increases in the level of polyphosphoinositide metabolism. During this period, cells in the slices released neuromediator factors into the perfusion fluid; transfer of these to recipient slices induced similar changes in the activities of intracellular regulatory system components in the recipient slices. After anoxia lasting 10 min, NMDA-mediated pathogenic hyperactivity of the calcium and phosphoinositide systems developed. Preliminary moderate activation of these systems by transient anoxia or neuromodulator factors released by cells in response to transient anoxia prevented disruption of intracellular regulatory system activity induced by subsequent longer-lasting anoxia.

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Самойлов

Lazarevich

Semenov

et al. 2003

Neuroscience and Behavioral Physiology

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Prophylactic transient hypoxia (preconditioning) increased neuron resistance to subsequent induction of severe hypoxia. Published data and results obtained by the authors on the molecular-cellular mechanisms of hypoxic preconditioning are presented. The roles of intracellular signal transduction, genome function, stress proteins, and neuromodulatory peptides in this process are discussed. The roles of glutamatergic as well as calcium and phosphoinositide regulatory systems and neuromodulatory factors as components of "volume" signal transmission are analyzed in hypoxic preconditioning-associated induction of functional tolerance mechanisms against the acute harmful effects of hypoxia on neurons in olfactory slices.

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Effect of syngeneic and xenogeneic apolipoprotein B-containing lipoproteins on immune response and phagocytosis in mice

Cited by 4 publications

References 7 publications

The role of volume transmission of adaptogenic signals in forming the adaptive reactions of the brain

The role of volume transmission of adaptogenic signals in forming the adaptive reactions of the brain

Involvement of intracellular regulatory systems in the adaptive effects of transient anoxia in vitro

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