Effect of Synthetase Inhibitors and Receptor Antagonists in Antigen-Induced Contraction of Human Lung Parenchyma

Shimoda, Terufumi; Matsuse, Hiroto; Matsuo, Nobutake; Takao, Atsuko; Obase, Yasusi; Kohno, Shigeru; Asai, Satoshi

doi:10.1016/s1081-1206(10)62965-1

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Cited by 5 publications

(2 citation statements)

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“…The primary in vivo effects of LTRAs are the inhibition of bronchoconstriction and inflammation. Fukushima et al (1998) showed that LTRAs were more potent in reducing antigen-induced contraction of human lung parenchyma compared with other therapies, including PG synthase and receptor inhibitors and antihistamine reagents in in vitro assays. The antiinflammatory effects of LTRAs have been well documented.…”

Section: B Currently Used Leukotriene Receptor Antagonist Drugs and mentioning

confidence: 99%

G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

Wendell¹,

Fan²,

Zhang³

2019

Pharmacol Rev

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Section: B Currently Used Leukotriene Receptor Antagonist Drugs and mentioning

confidence: 99%

G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

Wendell¹,

Fan²,

Zhang³

2019

Pharmacol Rev

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“…Leukotriene receptor agonists significantly reduce anaphylactic bronchoconstriction in passively sensitized human lung parenchyma in vitro compared with other anti-allergic drugs [18]. Leukotriene receptor agonists also have anti-inflammatory effects in a murine model of allergic asthma as they reduce airway eosinophilia and cytokine production from T lymphocytes [16].…”

Section: Pharmacologymentioning

confidence: 99%

Leukotriene receptor antagonists pranlukast and montelukast for treating asthma

Matsuse

Kohno

2013

Expert Opinion on Pharmacotherapy

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IntroductionThe prevalence of bronchial asthma, which is a chronic inflammatory disorder of the airway, is increasing worldwide. Although inhaled corticosteroids (ICS) play a central role in the treatment of asthma, they cannot achieve good control for all asthmatics and medications such as leukotriene receptor antagonists (LTRAs) with bronchodilatory and anti-inflammatory effects often serve as alternatives or add-on drugs. Several issues such as predicted responses, effects of peripheral airway and airway remodeling and alternative administration routes remain to be clarified before LTRAs PAGE 3 could serve a more effective role in the treatment of asthma. Areas covered

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Eicosanoids in parasites and parasitic infections

Daugschies

Joachim

2000

Advances in Parasitology Volume 46

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Effect of Synthetase Inhibitors and Receptor Antagonists in Antigen-Induced Contraction of Human Lung Parenchyma

Cited by 5 publications

References 36 publications

G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

G Protein–Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action

Leukotriene receptor antagonists pranlukast and montelukast for treating asthma

Eicosanoids in parasites and parasitic infections

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