Effect of Synthetic Smog on Spontaneous Activity of Mice

Boche, R; Quilligan, J. J.

doi:10.1126/science.131.3415.1733

Cited by 15 publications

(4 citation statements)

References 24 publications

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“…From pioneering work in the 1950s [35], inhalation of ozone is associated with many negative respiratory, cardiovascular, and immunological symptoms in humans and laboratory animals [20]. Significant but transient depressive effects of O 3 on voluntary behavior of laboratory rodents were also reported beginning in the 1960s [25]. Short‐duration O 3 inhalation exposure experiments on laboratory rodents documented depressions of feeding [27] and spontaneous wheel running locomotor [24–26] behaviors.…”

Section: Discussionmentioning

confidence: 99%

“…Significant but transient depressive effects of O 3 on voluntary behavior of laboratory rodents were also reported beginning in the 1960s [25]. Short‐duration O 3 inhalation exposure experiments on laboratory rodents documented depressions of feeding [27] and spontaneous wheel running locomotor [24–26] behaviors. Our results suggest that a single 4‐h exposure to environmentally recorded O 3 also depresses feeding behavior in adults of the toad B. marinus.…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory studies also indicate that acute (short‐term, single exposure) and chronic (long‐term, multiple exposures) O 3 exposure affects behaviors of animals, although specific mechanisms are generally not known. Laboratory rodents exposed to O 3 exhibit pronounced alterations in exploratory behavior [23,24], water maze performance [23], voluntary activity in running wheels [25,26], and feeding or drinking behavior [27].…”

Section: Introductionmentioning

confidence: 99%

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Ozone exposure affects feeding and locomotor behavior of adult Bufo marinus

Dohm¹,

Mautz²,

Doratt³

et al. 2008

Enviro Toxic and Chemistry

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Ozone (O3), a reactive component of air pollution, depresses feeding and voluntary locomotor behavior in laboratory rodents, but the effects of O3 on amphibian behavior are not known. We evaluated the effects of 4 h of exposure to air or ozone (0.6 microl/L), on two ecologically relevant behaviors of the toad Bufo marinus. Toads were offered five mealworms at 1, 24, and 48 h after exposure. One hour after exposure, O3-exposed toads ate fewer mealworms than did air-exposed toads (Fisher exact test, p=0.005). Within 24 h after exposure, all toads ate four or five mealworms. Because movement is a key component of toad feeding behavior, we tested additional toads (n=25) for voluntary locomotor behavior during three 1-h trials in a 2.9-m2 open-field arena. Mean (+/-standard deviation) total distance moved was: pre-exposure, 29+/-19.5 m; 1-h postexposure, 13+/-15.6 m; and 24-h postexposure, 17+/-17.4 m. The means were not statistically different by repeated measures analysis of covariance. Therefore, our results suggest that a single 4-h exposure to O3 depresses toad feeding behavior after exposure but had little effect on voluntary locomotor behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ozone exposure affects feeding and locomotor behavior of adult Bufo marinus

Dohm¹,

Mautz²,

Doratt³

et al. 2008

Enviro Toxic and Chemistry

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“…In 1960, Boche and Quilligan published some of their findings on the effects of synthetic smog on the running-wheel activity of mice. 3 Their results are presented a The research described in this article has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use.…”

Section: Effects On Naturally Occurring and Acquired Behaviormentioning

confidence: 99%

Animal Models for Assessing the Neurobehavioral Impact of Airborne Pollutants^a

MacPhail

Peele²

1992

Annals of the New York Academy of Sciences

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Growing concern over the potential health effects of airborne chemicals has fostered the need for animal models to complement and extend clinical and epidemiological studies. Animal models allow exploration of a much wider range of exposure conditions than is otherwise possible, and are essential for delving into the mechanisms of toxicity. Behavioral methods may be expected to play an important role in the development of animal models to address air quality issues.There has been a relatively long-standing, but generally not recognized, tradition of behavioral investigations in animals of air quality. Stewart,' for example, published findings on the effects of drugs and atmospheric conditions on the running-wheel activity of rats. Changes in the levels of activity occasionally occurred in the absence of treatment, and were attributed to the release of gases in the laboratory. Stewart may have been the first scientist to describe the behavioral effects of airborne pollutants in laboratory animals. Burrell's studies on carbon monoxide were more prospective.2 Burrell found that canaries were more sensitive to the adverse effects of carbon monoxide exposure, and that the behavioral reactions were more easily identified in canaries than in mice (TABLE 1). These early findings served as the basis for using canaries as sentinels of air quality in coal mines.

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