Effect of systemic hypertension on right ventricular morphology and function

Akintunde, AA; Akinwusi, PO; Familoni, OB; Opadijo, OG

doi:10.5830/cvja-2010-013

Cited by 27 publications

(24 citation statements)

References 29 publications

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“…Age was found to be the only determinant of RVDD while LV ejection fraction was a predictor of RVSD after adjusting for confounding variables. In a similar study, Akintunde et al [146] reported RV structural and functional alteration in hypertension and concluded that RVDD may be an early precursor of HHD in Nigerians.…”

Section: Correlates Of LV Mass In Hypertensive Nigeriansmentioning

confidence: 92%

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Ogah¹,

Okpechi²,

Chukwuonye³

et al. 2012

WJC

219

232

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To review studies on hypertension in Nigeria over the past five decades in terms of prevalence, awareness and treatment and complications. Following our search on Pubmed, African Journals Online and the World Health Organization Global cardiovascular infobase, 1060 related references were identified out of which 43 were found to be relevant for this review. The overall prevalence of hypertension in Nigeria ranges from 8%-46.4% depending on the study target population, type of measurement and cut-off value used for defining hypertension. The prevalence is similar in men and women (7.9%-50.2% vs 3.5%-68.8%, respectively) and in the urban (8.1%-42.0%) and rural setting (13.5%-46.4%). The pooled prevalence increased from 8.6% from the only study during the period from 1970-1979 to 22.5% (2000-2011). Awareness, treatment and control of hypertension were generally low with attendant high burden of hypertension related complications. In order to improve outcomes of cardiovascular disease in Africans, public health education to improve awareness of hypertension is required. Further epidemiological studies on hypertension are required to adequately understand and characterize the impact of hypertension in society.

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Section: Correlates Of LV Mass In Hypertensive Nigeriansmentioning

confidence: 92%

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Ogah¹,

Okpechi²,

Chukwuonye³

et al. 2012

WJC

219

232

View full text Add to dashboard Cite

show abstract

“…Cicala et al [14] analyzed right ventricular longitudinal function in arterial systemic hypertension by pulsed tissue Doppler in 30 normotensives and 30 hypertensives, free of cardiac drugs. Akintunde et al [15] intended to describe the impact of left ventricular pressure overload and hypertrophy due to hypertension on right ventricular morphology and function. One hundred subjects with systemic hypertension and 50 age-and gendermatched normotensive control subjects were used for this study.…”

Section: Resultsmentioning

confidence: 99%

“…The increase in the right-heart pressures among the essential hypertension patients was significantly different from the values in the normotensive controls. Akintunde et al [15] concluded that systemic hypertension is associated with right ventricular morphological and functional abnormalities and that right ventricular diastolic dysfunction may be an early clue to hypertensive heart disease. Cittadini et al [18] stated that right ventricular E/A ratio was strongly related to homologous left ventricular E/A ratio.…”

Section: Aim Of the Current Study Was To Analyze Impact Of Presence Amentioning

confidence: 99%

Relation of RV Function to Presence and Degree of Systemic Hypertension

Abdeltawab¹,

Eweda²,

Mostafa³

et al. 2017

J Cardiovasc Dis Diagn

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Hypertension is an important non-communicable disease in Africa. It is the most important cardiovascular risk factor. The effect of hypertension on left ventricle has been documented for long time, but sparse and consistent evidence shows an impact of hypertension on the right ventricle. The RV can be studied with many imaging and functional modalities. In clinical practice, echocardiography is the mainstay of evaluation of RV structure and function. Aim of this study was to analyze impact of presence and severity of systemic arterial hypertension (HTN) on right ventricular function measured by tissue Doppler echocardiography. For this aim we included sixty consecutive patients from outpatient clinics and thirty healthy age and sex matched individuals and made a full 2D and tissue doppler study for the RV and compared results for non-hypertensives, stage 1 and stage 2 hypertensives. Doppler data obtained at the tricuspid valve showed statistically significant results regarding E, E/A, DT and IVRT correlating the presence and degree of hypertension with RV diastolic function (p<0.001). The current study demonstrated that RV diastolic dysfunction not only is an early marker that is correlated to presence of systemic arterial hypertension but also showed it to be a marker of its severity and degree of control as conveyed by stage of hypertension.

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“…It is proposed that this results in increased RV pressure and compensatory RV hypertrophy. [12][13][14] Given the fact that it is well-established that obesity is linked to LV diastolic dysfunction, 8,15,16 we hypothesized that a similar mechanism of ventricular interactions occurs in obesity.…”

Section: Rider Et Al Rv Remodeling In Obesitymentioning

confidence: 99%

Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy

Rider

Lewis

Lewandowski

et al. 2015

Circ: Cardiovascular Imaging

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One of the potential reasons for the underinvestigation of RV remodeling in obesity lies in the fact that accurate 2-dimensional echocardiographic assessment of RV size and function is inherently more difficult as a result of the complexity of the shape of the RV, which, in contrast to the ellipsoidal shape of the LV, seems triangular, when viewed from the side, and crescentic, when viewed from above. This is hampered further by the increased difficulty of generating adequate acoustic windows in obesity. Despite these limitations, the majority of these studies have shown RV hypertrophy in obesity. [5][6][7][8] A few previous studies investigating RV geometry in obesity, have, in the main, not excluded subjects with obesityrelated comorbidities, such as hypertension, 9 which are known to have independent effects on RV mass.5 In contrast to echocardiography, cardiovascular magnetic resonance imaging is Background-As right ventricular (RV) remodeling in obesity remains underinvestigated, and the impact of left ventricular (LV) diastolic dysfunction on RV hypertrophy is unknown, we aimed to investigate whether (1) sex-specific patterns of RV remodeling exist in obesity and (2) LV diastolic dysfunction in obesity is related to RV hypertrophy. Methods and Results-Seven hundred thirty-nine subjects (women, n=345; men, n=394) without identifiable cardiovascular risk factors (body mass index [BMI], 15.3-59.2 kg/m 2 ) underwent cardiovascular magnetic resonance (1.5 T) to measure RV mass (g), RV end-diastolic volume (mL), RV mass/volume ratio, and LV diastolic peak filling rate (mL/s). All subjects were normotensive (average, 119±11/73±8 mm Hg), normoglycaemic (4.8±0.5 mmol/L), and normocholesterolaemic (4.8±0.9 mmol/L) at the time of scanning. Across both sexes, there was a moderately strong positive correlation between BMI and RV mass (men, +0.8 g per BMI point increase; women, +1.0 g per BMI point increase; both P<0.001). Whereas women exhibited RV cavity dilatation (RV end-diastolic volume, +1.0 mL per BMI point increase; P<0.001), BMI was not correlated with RV end-diastolic volume in men (R=0.04; P=0.51). Concentric RV remodeling was present in both sexes, with RV mass/volume ratio being positively correlated to BMI (men, R=0.41; women, R=0.51; both P<0.001

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Effect of systemic hypertension on right ventricular morphology and function

Cited by 27 publications

References 29 publications

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Blood pressure, prevalence of hypertension and hypertension related complications in Nigerian Africans: A review

Relation of RV Function to Presence and Degree of Systemic Hypertension

Obese Subjects Show Sex-Specific Differences in Right Ventricular Hypertrophy

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