Effect of systemic inhibition of prostaglandin synthesis on muscle protein balance after trauma in the rat

Fisher, Brian D.; Baracos, Vickie E.; Reid, Duncan

doi:10.1139/y91-125

Cited by 19 publications

(9 citation statements)

References 14 publications

(4 reference statements)

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“…In our study, EP 3 expression was downregulated in skeletal muscles of tumor‐bearing mice and was not normalized by indomethacin treatment, which indicates that EP 3 expression in skeletal muscle is not directly or proportionally related to systemic PGE 2 levels or to elevated IL‐1β, IL‐6 and TNF‐α activities in the host. Therefore, it is evident that net muscle protein catabolism in MCG 101‐bearing mice is not directly related to EP receptor control since indomethacin improved dry carcass weight of which skeletal muscle tissue is a major component, where increased PGE 2 has been proposed to induce net breakdown of skeletal muscle tissue 56, 57. Expression of EP 1 , EP 2 , EP 3 and IP in tumor tissue was not responsive to indomethacin, which however attenuated tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhood

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhood

et al. 2009

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“…The inflammatory response provides phagocytic cells for the removal of damaged muscle. In addition, muscle cells possess pathways of intracellular protein catabolism, which may be cytosolic or lysosomal in nature 30) . Membranebound vacuoles, often contain amorphous material (lysosomals), were a prominent feature of the damaged muscle cells by 48 hours post-injury.…”

Section: Discussionmentioning

confidence: 99%

An Overview of Muscle Regeneration Following Acute Injury

Fisher

Rathgaber

2006

J Phys Ther Sci

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The focus of this research was to investigate the efects of acute blunt trauma, on the ultrastructural and protein content of skeletal muscles. A simple device for producing a humane and reproducible experimental model of blunt trauma to rat muscle was used. Ultrastructural events in the traumatized muscle were observed over 14 days. From 0 to 2 days after trauma there was a marked loss of muscle protein content, associated with an acute inflammatory response. From day 3 to 14 days, the muscle underwent regeneration with a rapid proliferation of sarcolemmal nuclei, activation of satellite cells, and the restoration of sarcomeres. By three days post trauma, muscle protein content decreased (35-47%) compared to muscle of control rats (p>0.05).

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“…4 This treatment has been found in some studies to reduce muscle catabolism in the case of myositis ossificans, but in other studies it decreased the overall torque and force generation of affected muscles. 21,22 Surgical intervention is indicated if limited function and/or pain persists after maturation of heterotopic bone, if neurovascular impingement occurs, or if the lesion becomes unusually large, suggesting malignant transformation. Surgery is not recommended before 6 months because of the latency of maturation that sometimes occurs.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Deltoid Myositis Ossificans in a Weightlifter Using Anabolic Steroids

Schultzel¹,

Johnson²,

Rosenthal³

2014

Orthopedics

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A 40-year-old male weightlifter presented with a 6-month history of a painless mass in the right deltoid. He had no history of trauma to the shoulder other than an arthroscopic rotator cuff repair a few weeks earlier. Physical examination showed a firm, nontender mass located longitudinally and coinciding with the deltoid, measuring 12×14×4 cm. There was no limitation in range of motion or functioning. Magnetic resonance imaging (MRI) and computed tomography (CT) scans suggested a lobulated, heterogeneous mass with multiple areas of calcification that raised suspicion for soft tissue sarcoma vs myositis ossificans. Marginal resection of the soft tissue mass was performed, and pathologic studies confirmed the diagnosis of xanthogranulomatous myositis ossificans with dystrophic calcifications and central cystic degeneration. At 2-week follow-up, the patient had improved range of motion and pain, but he noted a second soft tissue mass in the left deltoid. The MRI and CT scans showed a 10.5×16×3.4-cm linear, lobulated lesion with multiple calcifications, similar in appearance to the contralateral deltoid. The patient admitted to frequently injecting anabolic steroids into his deltoids. Because the patient was asymptomatic on the left side and the MRI appearance of the left deltoid mass was similar to that of the myositis ossificans seen on the right side, the patient opted for nonsurgical treatment. This is a rare case of myositis ossificans occurring bilaterally in the deltoids after repeated injections of anabolic steroids. There is currently no known association between anabolic steroids and myositis ossificans. This condition often mimics malignant neoplasms, illustrating the necessity of resection for diagnostic confirmation.

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Effect of systemic inhibition of prostaglandin synthesis on muscle protein balance after trauma in the rat

Cited by 19 publications

References 14 publications

Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhood

Phenotypic and genetic differentiation of anxiety-related behaviors in middle childhood

An Overview of Muscle Regeneration Following Acute Injury

Bilateral Deltoid Myositis Ossificans in a Weightlifter Using Anabolic Steroids

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