Effect of Tadalafil on Renal Resistivity and Pulsatility Index in Partial Ureteral Obstruction

Abstract

Introduction: To investigate the effect of tadalafil on Resistivity Index (RI) and Pulsatility Index (PI) in partial unilateral ureteral obstruction (PUUO). Methods: Twelve New Zealand rabbits were assigned into two groups. Baseline renal Doppler ultrasonography (USG) was performed in all rabbits. The rabbits in group 1 received tadalafil for a month (10 mg/72 h) and group 2 was defined as sham. After 1 month, in both groups left PUUO was created. Renal Doppler USG was performed to measure RI and PI parameters of both kidneys on the 4th hour and 1st and 3rd days postoperatively. Results: Baseline renal Doppler USG revealed that there was no difference between two kidneys in both groups. The differences in mean RI and PI values of the kidneys between the sham and tadalafil groups were not statistically significant. Compared with the preoperative values, postoperative RI and PI values for the left kidneys were significantly increased in the period from 4 h to 3 days postoperatively in the sham group (p < 0.05). However, mean RI and PI values were not increased in the tadalafil group when compared with the sham group and this difference between the two groups was significant (p < 0.05). Conclusions: Tadalafil has a lowering affect on RI and PI in experimentally created PUUO.

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

“…Various studies concerning PDE5 inhibitors have reported different effects. These include intracellular NO production inhibiting platelet aggregation (9), improved renal blood flow in a model of partial ureteral obstruction induced in rats (10) and protection against tubular apoptosis (11). …”

Current Concepts on the Reno-Protective Effects of Phosphodiesterase 5 Inhibitors in Acute Kidney Injury: Systematic Search and Review

“…The main characteristics and results of the human studies evaluating the potential reno-protective effects of PDE5Is are summarized in Table 1 [17,24,38,39]. The main characteristics and results of the animal studies on currently proposed AKI models evaluating the potential reno-protective effects of sildenafil, tadalafil, icariin, vardenafil, zaprinast-udenafil are summarized in Table 2 [23,30,, Table 3 [29,35,45,49,[62][63][64][65][66][67][68][69][70][71][72][73][74], Table 4 [18,75,76], Table 5 [45,77,78], and Table 6 [21,40,79,80], respectively. The main characteristics and results of the animal studies in the AKI-CKD transition spectrum (focusing on renal function and/or structure alterations for up to three months, not fulfilling the KDIGO definition for CKD [6]) evaluating the potential reno-protective effects of sildenafil, tadalafil, icariin, vardenafil, zaprinast-udenafil are summarized in Table A1 [109,110], respectively (Appendix B).…”

Comparação entre padrões de sutura longitudinal e transversal na ureterotomia microcirúrgica em coelhos

“…Por anos, os coelhos vêm sendo o modelo experimental de escolha em pesquisas primárias para a avaliação da obstrução ureteral induzida e da insuficiência renal, em virtude da acessibilidade, do porte, da facilidade de manuseio e de manipulação cirúrgica (COLEY et al, 1995;KIM et al, 2004;AYYILDZ et al, 2009;LIMA et al, 2013;KAYA;ÇETİNKAYA, 2022;SU et al, 2022). Frente a isso e à similaridade anatômica com o diâmetro ureteral dos gatos, os coelhos são um modelo ideal para estudos primários com perspectivas para aplicação clínica em felinos.…”